Navigation Links
Constant High Blood Sugar Disables Insulin 'Off' Switch
Date:3/6/2008

Researchers say mouse study reversing that pattern offers hope of new diabetes treatments

THURSDAY, March 6 (HealthDay News) -- Chronically high blood glucose levels disable the molecular switch that normally turns off sugar production in the liver in response to increasing insulin levels, a California study finds.

This finding suggests that inhibiting the enzymatic pathway that disables the "sugar-off" switch (CRTC2) may help lower glucose levels in people with diabetes and reduce long-term complications associated with the disease, the researchers said.

The study, by researchers at the Salk Institute for Biological Studies, in La Jolla, Calif., is published in the March 7 issue of Science.

In healthy people, the CRTC2 switch turns on glucose production in the liver when blood glucose levels decline during the night. After a meal, insulin shuts down CRTC2, thus ensuring that blood sugar levels don't rise too high.

But in many people with type 2 diabetes, CRTC2 no longer responds to increasing insulin levels. As a result, the liver keeps on pumping out glucose, even if blood glucose levels are already elevated.

In research with mice, the Salk team focused on the hexosamine biosynthetic pathway. Activation of this pathway promotes the addition of sugar molecules to proteins, a process called O-glycosylation.

"It had been known that increases in the concentration of circulating glucose activate the hexosamine biosynthetic pathway. But we had no idea that the resulting O-glycosylation would lock CRTC2 in the 'on' position," study first author Renaud Dentin said in a prepared statement.

Dentin's team decreased the activity of the hexosamine biosynthetic pathway in insulin-resistant diabetic mice and in mice fed a high-fat diet (both groups had high blood sugar levels) and found a marked improvement in glucose tolerance and insulin sensitivity.

More information

The American Diabetes Association has more about hyperglycemia.



-- Robert Preidt



SOURCE: Salk Institute for Biological Studies, news release, March 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Estrogen Levels in Blood Predict Breast Cancers Return
2. UCLA researchers find blood stem cells originate and are nurtured in the placenta
3. Greatest Satisfaction Preserving Granddaughters Cord Blood Stem Cells
4. Sticky blood protein yields clues to autism
5. Actor Rob Brown Rushes to Gain Ground Against Blood Cancer
6. Common Rheumatoid Arthritis Drug Wont Raise Blood Cancer Risk
7. Researchers find possible target to treat deadly bloodstream infections
8. New blood marker may predict prostate cancer spread
9. Drugs used for cancer-associated anemia linked with increased risk of blood clots, death
10. Blood Clots in Legs, Lungs Predispose Patients to Repeat Episodes
11. Mechanism of blood clot elasticity revealed in high definition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/25/2017)... 25, 2017  EpiVax, Inc., a leader in ... immune-engineering today announced the launch of EpiVax Oncology ... personalized therapeutic cancer vaccines. EpiVax has provided $500,000 ... to enabling technologies to the new precision immunotherapy ... EpiVax Oncology as Chief Executive Officer. Gad brings ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
Breaking Medicine Technology: