Navigation Links
Consortium identifies genome regions that could influence severity of cystic fibrosis
Date:5/23/2011

CHAPEL HILL, N.C. A team of researchers, including a number from the University of North Carolina at Chapel Hill School of Medicine, have pinpointed regions of the genome that contribute to the debilitating lung disease that is the hallmark of cystic fibrosis.

Their findings provide insight into the causes of the wide variation in lung disease severity experienced by CF patients. It also points the way to new diagnostic markers and therapeutic approaches for this and more common lung diseases such as COPD.

This study, which appears online Sunday, May 22, 2011 in the journal Nature Genetics, is among the first reported genome-wide scans of a single gene disorder. It was the work of the North America CF Gene Modifier Consortium, which brought together dozens of investigators from the United States and Canada to identify which regions of the genome are associated with lung disease severity in almost 3,500 CF patients.

"This cystic fibrosis discovery showcases the valuable information that can be obtained when scientists work together on genome wide association studies," said Susan B. Shurin, MD, acting director of the NHLBI. "Now we are closer to understanding why patients with the exact same genetic mutation in the cystic fibrosis gene have such widely varying manifestations of lung disease, and closer to finding new therapies."

CF is a genetic disease that causes the lungs to clog up with thick, sticky mucus that is prone to infection. Though every CF patient carries mutations in both copies of the same gene coding for a protein called cystic fibrosis transmembrane conductance regulator or CFTR symptoms can vary widely from patient to patient. For instance, some patients can have such severe lung disease that they are near death at the age of 10, whereas others can have nearly normal lung function at the age of 35.

"There is very good reason to believe that what we have discovered in CF lung disease could a
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Biodesign hosts international consortium on screening for lung cancer
2. LSTM leads new £6 million ($9.3 million) health systems knowledge consortium
3. International consortium to examine the impact of medical devices on health and retirement
4. NCI awards $11.5 million to Fred Hutchinson Cancer Research Center to lead breast cancer consortium
5. Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced
6. OHSU research team joins elite consortium dedicated to curing type 1 diabetes
7. Elsevier partners with Helinet to strengthen consortiums leadership in health sciences education
8. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
9. Research consortium at CHLA receives $410,000 to study leukemia and lymphoma
10. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
11. National Nursing Centers Consortium Responds to New Federal Investment in Nurse-Managed Health Clinics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 2014 According to a new ... Platforms (Land, Airborne, Naval), Application (Software Defined Radios, ... Geography (North America, Asia-Pacific, Europe, the Middle East ... by MarketsandMarkets, the market is estimated to be ... register a CAGR of 5.56% to reach $39.52 ...
(Date:7/10/2014)... July 10, 2014 Parker Waichman ... the rights of victims injured by defective medical ... lawsuit over allegations that the woman’s hidden, aggressive ... power morcellator used during a routine laparoscopic supracervical ... Richard Wolf Medical Instruments Corporation over its Wolf ...
(Date:7/10/2014)... -- Most professional football players who have shoulder stabilization ... new study finds. Shoulder instability is a common ... after surgery to fix the problem has been unclear, ... 60 players who had shoulder stabilization surgery. Ninety percent ... play, defined as playing in at least one regular ...
(Date:7/10/2014)... HealthDay Reporter THURSDAY, July ... that break out regularly between outspoken celebrities or loudmouth pundits ... relationship, a new study suggests. High amounts of Twitter ... the couple is in a long-term relationship, according to findings ... turn, that friction can lead to cheating and breakups, the ...
(Date:7/10/2014)... a microchip-based device developed at the Massachusetts General Hospital ... Cancer Center can be cultured to establish cell lines ... July 11 issue of Science , an MGH ... a tumor,s genetic mutation over time and changing susceptibility ... cells from the blood that represent those present in ...
Breaking Medicine News(10 mins):Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 2Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 3Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 5Health News:Shoulder Surgery Gets NFL Players Back in the Game 2Health News:Are You Tweeting Your Marriage Away? 2Health News:Are You Tweeting Your Marriage Away? 3Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3
... Georgia Institute of Technology, US and the John Innes Center, ... defends itself from the defense mechanism of the host. //The ... Journal Nature. ,Pathogenic bacteria cause food borne ... which enters with the food causes illness in some cases ...
... accounts committee report says that many terminally ill cancer patients ... could help them tide over financial difficulties related to their ... quarters of cancer patients are not aware of the benefits ... they are missing out on ?200 million each year. ...
... Four HIV patients who have found resistant to most of the ... be given the experimental drugs TMC 114 and TMC 125 as ... with experimental drugs are undertaken under strict protocols this study is ... lives of these four HIV patients. ,TMC ...
... with breast cancer and adversely affects the long term prognosis ... issue of the American Journal of Epidemiology has said. // ... conclusions that were arrived at in several Western studies and ... hindrance to complete recovery from breast cancer. Study co-author Dr. ...
... It is alarming news that there is a steep rise in ... seen in Canada. The reason attributed to this phenomenon is lack ... and asserting the use of a condom. , "The statistics ... 55, vice-chair of Voices of Positive. , ,Of the 2,529 ...
... a toll on people’s cardiac health as early as their ... who report high job strain - the combination of heavy ... found to have thicker carotid intima-media thickness (IMT). IMT is ... atherosclerosis, the narrowing and stiffening of the arteries, even in ...
Cached Medicine News:Health News:Many young women affected by HIV 2
(Date:7/10/2014)... -- CVS Caremark Corporation (NYSE: CVS ) today ... dividend of $0.275 (27.5 cents) per share on the corporation,s ... to holders of record on July 21, 2014. ... to helping people on their path to better health as ... States . Through the company,s more than 7,600 CVS/pharmacy ...
(Date:1/15/2014)... ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" research ... http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging of ... orthopedic instrument industry has seen rapid development ... 3.28 billion yuan in 2006 to 9.85 billion yuan ...
(Date:1/15/2014)... GRAND RAPIDS, Mich. , Jan. 15, 2014 As ... of the flu virus, select Meijer pharmacies in ... and strep throat to eligible patients, enabling Meijer pharmacists to ... under strict protocol set by a physician participating in the ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... System provides anterior column support for single ... T1 to L5. The system consists of ... cages that are stacked to a desired ... Carbon Fiber Reinforced Polymer material emulates the ...
... Cage System provides anterior column support for ... from T1 to L5. The system consists ... Polymer cages that are stacked to a ... Peek Carbon Fiber Reinforced Polymer material emulates ...
Anterior Interbody fusion with proven clinical performance. Large hole design. Request info fda status for sale....
... The Jaguar Lumbar I/F Cage system ... designed to separate the mechanical and biologic ... The Jaguar Lumbar I/F Cage provides a ... of PLIF, and uses autologous cancellous bone, ...
Medicine Products: