Navigation Links
Considerably more patients may benefit from effective antidiabetic drug
Date:9/17/2012

The antidiabetic drug metformin is not prescribed for patients with reduced kidney function because the risk of adverse effects has been regarded as unacceptably high. A study at Sahlgrenska Academy, University of Gothenburg, Sweden, has found that the risks have been substantially overrated. As a result, many more patients with diabetes may be able to enjoy the benefits of the medication.

Type 2 diabetes, a very common condition, is increasingly prevalent around the world. Keeping diabetes under control and preventing complications requires not only lifestyle changes, but drug therapy to reduce blood glucose levels.

Among the most effective and frequently prescribed antidiabetics is metformin, which has been shown in a number of studies to lower the risk of death from cardiovascular disease. Because the drug has been considered causing an increased risk of developing a rare but life-threatening adverse effect known as lactic acidosis, it is not prescribed for patients with reduced kidney function.

Researchers at Sahlgrenska Academy, University of Gothenburg and Uppsala University have conducted a study involving 51,700 patients with type 2 diabetes from the Swedish national diabetes register and found that the risks are exaggerated.

The Gothenburg study shows that metformin is more effective than other glucose lowering drugs when it comes to reducing the risk of cardiovascular disease, serious infection and death in patients with normal kidney function, but also in patients with mild kidney impairment.

"Furthermore, patients with mild to moderate kidney impairment do not run an elevated risk of adverse effects from metformin,"says Nils Ekstrm, a researcher at Sahlgrenska Academy. "Thus, the drug can be prescribed for many more patients with diabetes than is currently the case."

According to Nils Ekstrm, a number of other countries already recommend metformin for patients with mild kidney impairment. "It is important to keep in mind tha
'/>"/>

Contact: Nils Ekstrm
nils.ekstrom@gu.se
46-702-890-121
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sound level around seriously ill patients like a busy road
2. Simple tool may help evaluate risk for violence among patients with mental illness
3. Study: Gingko biloba does not improve cognition in MS patients
4. Cystic fibrosis patients of low SES are less likely to be accepted for lung transplant
5. Perceived control affects complication rates in patients with acute coronary syndrome
6. Physicians suggest expert recommendations ignore vital issues for patients
7. Docs Sensitivity to Patients Feelings Tied to Good Outcomes
8. Technique using CT linked with improved detection of lymph node metastasis in patients with melanoma
9. Tight blood sugar control for pediatric cardiac surgery patients does not improve outcomes
10. No proof that patients lose weight after joint replacement surgery
11. Language Barrier Hurts Elderly Asthma Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- The U.S. Food and Drug ... Thursday. Trulicity is part of a class of once-a-week injectable ... type 2 diabetes. "Trulicity is a new treatment ... treatment regimens to control blood sugar levels in the overall ... of the FDA,s Office of Drug Evaluation II, said in ...
(Date:9/19/2014)... The Alliance for Bangladesh Worker Safety ... Fire Protection Association (NFPA), a recognized international leader ... a Memorandum of Understanding signed by both organizations, ... stakeholders with information, guidance and access to training ... safety of workers in ready-made garment (RMG) factories ...
(Date:9/19/2014)... MetroMD, a leading anti-ageing clinic has called its ... health. This therapy has grown tremendously across USA in the ... safe and dependable. It has far reaching benefits for ageing ... a very healthy and active lifestyle even beyond their middle ... senior therapist at MetroMD said, “HGH or Human Growth hormones ...
(Date:9/19/2014)... September 19, 2014 "I have difficulty ... wrinkles due to stretching the skin around my eyes ... "This inspired me to design a more convenient method ... LENS SYSTEM provides a quicker, easier, more sanitary method ... to perform this task manually, saves time and effort, ...
(Date:9/19/2014)... - New research published today in the online journal ... reach 6,800 in West Africa by the end of ... , Arizona State University and Harvard University researchers ... rise in cases significantly increased in August in Liberia ... was put in place, indicating that the mass quarantine ...
Breaking Medicine News(10 mins):Health News:FDA Approves Another Weekly Injectable Drug for Type 2 Diabetes 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:MetroMD Announces Better HGH Therapy - the ‘God Particle’ of Human Health 2Health News:Research predicts possible 6,800 new Ebola cases this month 2
... North Carolina in Chapel Hill that was published in the ... two genes - C282Y and H63D, which are linked to ... increased risk of developing colon cancer. For the research, the ... which, more than 400 already had colon cancer, and were ...
... at Trinity College, Dublin, Ireland, have found from a ... arterial stiffness after smoking even one cigarette in both ... effects of smoking on large artery properties in 185 ... years. 116 non-smokers// were compared with 41 chronic smokers ...
... have traditionally been treated by removing a disc or placing ... together. Now, an artificial disc which is being studied as ... phase one study that was recently completed compared the prosthesis ... patients// were randomized, with one having a fusion operation for ...
... is being reassessed to find out if it could again ... and leprosy. The drug which is unlicensed in Europe was ... morning// sickness. However, it was banned after mothers who took ... for the Evaluation of Medicinal Products (EMEA) is now considering ...
... among children that were known until now were chickenpox, ... neurologists have found that stroke is also among one ... go unnoticed. A National Hospital's database analysis by Dr. ... California showed that four in 1000 newborns had a ...
... recent health survey across England showed that many do ... cancer and other serious diseases. The survey included nearly// ... trends were revealed by the study. ,The survey ... eating and household income. Almost 40% of women in ...
Cached Medicine News:Health News:Artificial discs available as replacements for damaged discs 2Health News:Stroke also in list of common childhood ailments 2
(Date:9/19/2014)... TRIANGLE PARK, N.C. , Sept. 19, 2014 ... focused on cloud-based drug design and development, partnering ... The company,s mission is to design new drugs ... 1 and 2 partners to further their development. ... its portfolio investments. To support this business model, ...
(Date:9/19/2014)... Sept. 19, 2014  Diplomat, the nation,s largest independent ... Dreyer to the Board of Directors on September ... will also serve as chair of the Audit Committee. ... of accounting, financial, compliance and operating experience in the ... served as chief financial officer, chief operating officer and ...
(Date:9/19/2014)... WALTHAM, Mass. , Sept. 19, 2014  Alere ... in rapid diagnostics, issued the following statement today in ... Combating Antibiotic-Resistant Bacteria. "As the global leader ... President for establishing a national strategy to address the ... continuing to work with the Administration on initiatives to ...
Breaking Medicine Technology:Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2David Dreyer Appointed to Diplomat Board of Directors 2Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2
... Oct. 12 Ethicon Endo-Surgery, Inc., today ... at the 95th Annual Clinical Congress of the ... technologies of worldwide leading HARMONIC® ultrasonic and ENSEAL® ... delivery options that provide superior energy application for ...
... 12 Stereotaxis, Inc. (Nasdaq: STXS ) announced today ... Stereotaxis common stock have exercised in full their over-allotment option ... stock. The 7,475,000 shares of Stereotaxis common stock in ... option, are being sold at a price to the public ...
Cached Medicine Technology:Ethicon Endo-Surgery Unveils Full Energy Portfolio for First Time at American College of Surgeons Clinical Congress 2Ethicon Endo-Surgery Unveils Full Energy Portfolio for First Time at American College of Surgeons Clinical Congress 3Stereotaxis Announces Underwriters' Exercise of Over-Allotment Option 2Stereotaxis Announces Underwriters' Exercise of Over-Allotment Option 3
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... Splint uses safe, mild to moderate force ... at the MP joints. Dorsal-based splint does ... ulnar polycentric hinges located at the MP ... malleable finger rings can be individually shaped ...
... constructed of a durable heat moldable thermoplastic for ... of the hand and fingers from stress following ... later stages of the healing process. , ... positions the wrist at 30° of flexion, the ...
Bunell Mini-Modified Safety Finger Pin reduces PIP flexion contractures....
Medicine Products: