Navigation Links
Considerable added benefit of ipilimumab in advanced melanoma
Date:11/9/2012

The humanized antibody ipilimumab (trade name Yervoy) has been approved since August 2011 for the treatment of adult patients with advanced melanoma (black skin cancer) who have already been treated. The term "advanced" means that the melanoma can no longer be removed by an operation or that metastases have formed. The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG). According to the findings, the drug offers major advantages with respect to overall survival, but is accompanied by major potential harm in the form of side effects. The overall conclusion is that ipilimumab offers considerable added benefit.

"Best supportive care" as appropriate comparator therapy

As specified by the Federal Joint Committee (G-BA), ipilimumab was to be compared with so-called "best supportive care". This means the best possible supportive therapy, optimized for the individual patient, which guarantees alleviation of the symptoms and improvement in the quality of life.

The only study relevant to this benefit assessment compared ipilimumab in combination with "best supportive care" with "best supportive care" alone. This study was informative (randomized controlled trial, RCT) and included three parallel study arms. Patients in arm 1 were treated with ipilimumab. Patients in arm 2 were treated with ipilimumab and an experimental tumour vaccine (gp100), which has been examined in studies since 1996, but which has not yet been submitted for approval. The patients in the comparator arm (arm 3) were given a placebo and the tumour vaccine. All patients in the study were also given "best supportive care".

In its assessment, the Institute came to the conclusion that the administration of gp 100 had no relevant influence on the effects of ipilimumab measured in this study, in comparison to "best supportive
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
0049-022-135-6856
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Abiraterone: Indication of considerable added benefit in certain patients
2. Vandetanib in thyroid cancer: No proof of added benefit
3. Belatacept after a kidney transplant: Minor added benefit for certain patients
4. Added benefit of Cannabis sativa for spasticity due to multiple sclerosis is not proven
5. Tafamidis: Approval denotes proven added benefit
6. Telaprevir: Added benefit in certain patients with hepatitis C
7. Keeping Up a Healthy Lifestyle Pays Off in Added Years: Study
8. Belimumab for lupus erythematosus: Added benefit not proven
9. Added benefit of fampridine is not proven
10. Added benefit of eribulin in breast cancer is not proven
11. Added benefit of linagliptin is not proven
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 The U.S. Pharmacopeial Convention is ... of Clinical Pharmacy Services at North Carolina State’s College ... the 2015 Beal Award for Distinguished Volunteer Service—the organization’s ... on the contributions of volunteer experts to direct its ...
(Date:1/22/2015)... 2015 Woodloch Pines, an all-inclusive family ... by TripAdvisor as the number one best large hotel for ... the world for their annual Travelers’ Choice Awards. , ... The website is home to millions of unbiased and honest ...
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put ... muscle by up to 30lbs in less than 12 weeks ... Stan Stevenson, prompting an investigative review. , “Our Incredible ... diet formula that allows the body to pack on a ...
(Date:1/22/2015)... New York, New York (PRWEB) January 22, 2015 ... ( http://www.vaginalmeshlawsuit2015.com/ ) in the U.S. District Court, Southern District ... against C.R. Bard, Inc. in that proceeding’s first bellwether trial. ... defense request for a new trial after finding that C.R. ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining the ... . , Auto insurance quotes help many drivers find ... necessary to call an agent or visit an agency for ... single website: http://autocarinsurancebest.com/ . , Every business who relies ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Commercial Auto Insurance Provides Several Important Features! 2
... has pledged 200 million dollars to fight AIDS. The ... designed to pay for treatment and prevention of HIV/AIDS, ... together killed some 5.5 million people last year, the ... Organization (WHO). ,The sheer number of those infected ...
... the May issue of the journal Epidemiology, high levels of ... impair male reproductive function. The human body metabolises DDT to ... 24 men aged 16 to 28 who had not been ... the high DDE levels correlated to low levels of testosterone, ...
... warned doctors that their names could be removed from the ... were found guilty of indulging in female foeticide. ,The ... which has come out with a disturbing picture of male-female ... of six. ,While there was slight improvement in the ...
... painful and bothering one is the trauma of going through ... diabetics is the finger stick. There are unfortunate patients who ... more than ten to twenty years or so. The main ... with them. But researchers and manufacturers have increasingly been developing ...
... fluid in the ears does not improve speech, hearing or ... two reasons for ear tube surgery -- persistent, severe ear ... otherwise healthy child. Doctors have been concerned that if surgery ... long-term developmental impairment. ,"We were led to the conclusion ...
... researchers in California say, may actually cause more diseases ... cause disease, including Lyme disease and Rocky Mountain spotted ... Clinical Microbiology implicates ticks in other maladies, including cat ... as Bartonella, cause this infection, as well as another ...
Cached Medicine News:Health News:Researchers urge caution in using ear tube surgery 2Health News:Researchers urge caution in using ear tube surgery 3
(Date:1/22/2015)... Colo. , Jan. 22, 2015  BiOptix is pleased ... as Vice President of Chemistry and Biochemistry. Scott joins ... Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course of ... development. "Scott is a nationally recognized thought ...
(Date:1/22/2015)... /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), ... for cardiovascular disease and overall health is pleased to provide ... and its outlook for 2015 from the CEO, Mr. ... We would like to take this opportunity to share with ...
(Date:1/22/2015)... 22, 2015  Profil Institute for Clinical Research, Inc., a ... announced today a new textbook,  Translational Research Methods for ... a leading global scientific publisher. The textbook ... for use in early phase clinical studies of new ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... Heart Health Tour is heading south to San Antonio, ... in San Antonio,s McAllister Dog Park. From 3 p.m. ... will be performing on site heart screenings in a ... canine heart disease. (Photo: http://www.newscom.com/cgi-bin/prnh/20100911/CG63271 ...
... (NYSE: LLY ) today announced that the U.S. ... Lilly,s position that a class should not have been certified ... insurers who act as third-party payors alleged that they overpaid ... plaintiffs, overpricing claims should not go forward.   ...
Cached Medicine Technology:Free Dog Heart Checks at McAllister Park 2Free Dog Heart Checks at McAllister Park 3U.S. Court of Appeals Reverses Third-Party Payor Class Certification Suit Against Lilly 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: