HIV therapy in pregnancy-data support WHO recommendations
In an observational cohort study from Cte d'Ivoire, Fran ois Dabis and colleagues report on prevention of mother-to-child HIV transmission among women receiving antiretroviral therapy according to World Health Organization recommendations.
Citation: Tonwe-Gold B, Ekouevi DK, Viho I, Amani-Bosse C, Toure S, et al. (2007) Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: Evaluation of a two-tiered approach. PLoS Med 4(8): e257.
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Defining childhood severe falciparum malaria for intervention studies
The accepted definition of severe malaria is appropriate for clinical purposes, but Philip Bejon and colleagues show its specificity in clinical trials may be improved by a parasite density threshold and by excluding children with certain conditions. The article is discussed in a related perspective.
Citation: Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, et al. (2007) Defining childhood severefalciparum malaria for interventionstudies. PLoS Med 4(8): e251.
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University of Oxford
Nuffield Department of Medicine
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Related PLoS Medicine Perspective article:
Citation: Anstey NM, Price RN (2007) Improving case definitions for severe malaria. PLoS Med 4(8): e267.
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FROM THE PLoS MEDICINE MAGAZINE SECTION:
HIV denialists spread misinformation onlineconsequences could be deadly
The Internet is serving as a fertile medium for "HIV denialists" to spread false ideas about HIV/AIDS, which could have terrible public health consequences, say scientists in a policy paper in PLoS Medicine.
"It may seem remarkable that, 23 years after the identification of HIV, there is still denial that the virus is the cause of AIDS," say Tara Smith (University of Iowa College of Public Health) and Steven Novella (Yale University School of Medicine). But with the arrival of the Internet, HIV denialist organizations such as "Reappraising AIDS" have reignited their campaign to spread misinformation.
There is a consensus in the scientific community that HIV is the cause of AIDS, based upon over two decades of robust research. Deniers must therefore reject this consensus, say Smith and Novella, "either by denigrating the notion of scientific authority in general, or by arguing that the mainstream HIV community is intellectually compromised."
It is therefore not surprising, they say, that much of the newer denial literature on the Internet reflects a basic distrust of authority and of the institutions of science and medicine. Distrusting mainstream medical practitioners, many HIV deniers turn to unproven alternative medicines in search of treatment.
Many members of the general public do not have the scientific background to critique the assertions put forth by these groups, say Smith and Novella. Those who believe the false information spread by HIV denialists could end up putting themselves at risk of HIV infection (e.g. by abandoning safe sex), while those who are already infected could end up seeking unproven, ineffective remedies.
"The effect of denial groups on public perception of HIV infection is an area ripe for careful research, they say as this denial can have lethal consequences."
Citation: Smith TC, Novella SP (2007) HIV denial in the Internet era. PLoS Med 4(8): e256.
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Performance-based funding provides powerful incentives to scale up the fight against HIV, TB, and malaria, argues a team of authors from the Global Fund.
Citation: Low-Beer D, Afkhami H, Komatsu R, Banati P, Sempala M, et al. (2007) Making performance based funding work for health. PLoS Med 4(8): e219.
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The Global Fund to Fight AIDS, Tuberculosis and Malaria
Performance Evaluation and Policy
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|Contact: Andrew Hyde|
Public Library of Science