Navigation Links
Connecting cancer genes
Date:5/15/2008

ng additional genes that might act to suppress tumour development, which are not readily detected in most surveys.

Human cancer cells frequently contain many mutations that are not involved in the development of cancer do not drive cancer development but are produced by increased mutation rates in cancer cells and are 'passengers'. Discerning which are driver and which are passenger mutations is a challenge for human cancer gene studies.

"The benefit of our system in the mouse is that, unlike human tumours, which usually contain many different types of genetic alternations, the causal mutations that initiate these tumours in mice can be easily identified and studied," explains Dr Adams, "These studies are complementary to and enrich the analysis of human cancers."

The project was made possible by the Sanger Institute's high-throughput sequencing and computational resources, which allowed the team to identify new potential cancer genes in the mouse. By comparing their data to genome-wide human cancer datasets generated by the Sanger Institutes' Cancer Genome Project, they could show that at some of the of the newly identified genes were potentially relevant to human cancer formation.

The team are currently carrying out other cancer screens using viruses and additional methods to disrupt cancer genes. These screens are searching for genes and gene interactions in the formation of bowel, lymphoid and breast cancers.


'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New England Technology Foundation Announces Connecting for Childrens Charities 2008 Event
2. Prescription for Change: New Survey Shows ePrescribing Connecting with its Biggest Skeptics ... Physicians
3. GigaLinx Unveils GEViewer(TM)- Industrys First Solution for Directly Connecting a GigE Camera to a Monitor
4. Drug therapy to bolster immune system cells found effective toward childhood cancer
5. Susan G. Komen for the Cure(R) Encourages Nation to Go Passionately Pink by Donning Pink, Donating Funds to End Breast Cancer Forever
6. Lowering Dietary Fat May Help Prevent Prostate Cancer
7. U of Minnesota researcher discovers the starting point of sun-induced skin cancer
8. Reducing intake of dietary fat prevents prostate cancer in mice
9. AUA 2008: Access to urologists and prostate cancer screenings lead to better outcomes for patients
10. Cool New Treatment for Hot Flashes in Breast Cancer Survivors
11. Cool new treatment for hot flashes in breast cancer survivors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Hospital Pediatrician-in-Chief Jon McCullers, MD, was recently invited ... of Nature Reviews Microbiology , one of ... a world-renowned infectious disease specialist, and chair of ... Tennessee Health Science Center, analyzed the epidemiology and ... 1968 pandemics, as well as more recent 2009 ...
(Date:4/17/2014)... 10 million older Americans suffer from depression, often brought ... new research a project that followed the lives ... found that Internet use among the elderly can ... percent. , "That,s a very strong effect," said Shelia ... studies and media who led the project. "And it ...
(Date:4/17/2014)... BostonResearchers from Boston University School of Medicine (BUSM) ... alcohol consumption in an experimental model. The findings, ... and Alcohol Abuse , may lead to more ... alcohol is one of the leading causes of ... significant negative economic impact by limiting the productivity ...
(Date:4/17/2014)... Cesar A. Arias, M.D., Ph.D., at The University of ... a new superbug that caused a bloodstream infection in ... 17 issue of The New England Journal of ... a class of highly-resistant bacteria known as methicillin-resistant ... cause of hospital and community-associated infections. The superbug has ...
(Date:4/17/2014)... blood flow and alleviates muscle soreness after exercise, ... University of Illinois at Chicago. , The study, ... Archives of Physical Medicine and Rehabilitation , ... people who had not exercised, suggesting that massage ... of physical activity. , Improved circulation and relief ...
Breaking Medicine News(10 mins):Health News:Internet use can help ward off depression among elderly 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:New MRSA superbug emerges in Brazil 2Health News:Massage therapy improves circulation, eases muscle soreness 2
... ... ‘death panel’ claim as the year’s biggest lie. Finalist for biggest lies also include ... ... PolitiFact.com , the Pulitzer Prize-winning fact-checking Web site of the St. Petersburg Times, ...
... WASHINGTON, Dec. 20 Following is the daily "Profile America" feature ... , SUNDAY, DECEMBER 20: FIRST ORGAN TRANSPLANT , ... transplant in the U.S. was performed this week in 1954 in ... from one identical twin to another, who lived just over eight ...
... health care focuses on costs, a new study from North ... to think of health care spending as an investment that ... projections of health care costs and financing may be unduly ... investment in future capital, contributing to a productive workforce, rather ...
... , WASHINGTON, Dec. 19 Official statement ... , "Majority Leader Reid,s amendment to the Senate health care bill ... current federal law and policy. It does not prevent federal ... protect health care providers who choose to exercise their rights of ...
... , Calls on Senator Ben Nelson to Not ... Senate Majority Leader Harry Reid (D-Nev.) released his long awaited ... The new language is being trumpeted as including an opt-out ... bill worse by requiring the state to either cover all ...
... out of reach of little hands , SATURDAY, Dec. 19 ... at least judging by statistics from a single hospital, but ... say they should be on the list of seasonal safety ... children are treated at Children,s Hospital Boston,s emergency department each ...
Cached Medicine News:Health News:PolitiFact Names 'Death Panels' Claim the Lie of the Year 2Health News:U.S. Census Bureau Daily Feature for Dec. 20 2Health News:Study shows health care spending spurs economic growth 2Health News:Americans United for Life Action: 'Senate Health Care Bill Absolutely Fails To Meet Abortion and Life Protections.' 2Health News:Americans United for Life Action: 'Senate Health Care Bill Absolutely Fails To Meet Abortion and Life Protections.' 3Health News:FRC Rejects Phony Abortion 'Compromise' 2
(Date:1/15/2014)... Calif. , Jan. 15, 2014 Massachusetts ... (NASDAQ: AMGN ) announced today that ... discover and validate new therapeutic targets and develop ... chronic disorder that affects millions worldwide. The MGH-Broad-Amgen ...
(Date:1/15/2014)... LOUISVILLE, Ky. , Jan. 15, 2014  Manufacturers, ... technologies must be able to protect their most ... (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because ... Industry, it steadfastly remains one of the most ...
(Date:1/15/2014)...  Echo Therapeutics, Inc. (Nasdaq: ECTE ) ("Echo"), ... as a non-invasive, wireless continuous glucose monitoring system, today ... and Interim CEO of Echo Therapeutics, will present at ... Mr. Doman will make a corporate ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... Conatus Pharmaceuticals Inc., a privately held, clinical stage ... Hepatitis C Virus (HCV), announced today that Steven J. ... at the Montgomery Healthcare Conference being held in Menlo ... of only 30 companies selected to present to this ...
... Hospital of Arcadia, California, has launched an integrated ... solutions designed to help improve the quality of ... health care information technology subsidiary of Quest Diagnostics ... solution to help Methodist reduce the length of ...
Cached Medicine Technology:Conatus Pharmaceuticals to Present at the Montgomery Healthcare Conference 2Methodist Hospital Adopts New Technology Solutions to Improve Care for California Patients and Reduce Operating Costs 2Methodist Hospital Adopts New Technology Solutions to Improve Care for California Patients and Reduce Operating Costs 3Methodist Hospital Adopts New Technology Solutions to Improve Care for California Patients and Reduce Operating Costs 4
The Optima III 45 cm line of laparoscopic hand instruments is ideal for operative laparoscopic/endoscopic procedures or when a longer instrument is needed....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Medicine Products: