Navigation Links
Connecting cancer genes

A large genetic study in mice has identified hundreds of genes involved in the development of cancer by examining the DNA of more than 500 lymphomas to find the cancer causing mutations.

The study found just over 10,000 mutations in total, which together implicate almost 350 regions in the mouse genome in cancer formation. 50 of these regions correspond to genes known to be involved in human cancers while the other regions were novel, adding to our picture of the complex set of diseases that are cancers.

The results were obtained by an international consortium of researchers, led by Drs Anton Berns, Maarten van Lohuizen and Lodewyk Wessels from the Netherlands Cancer Institute (NKI), and Dr David Adams, Experimental Cancer Genetics, from the Wellcome Trust Sanger Institute and are published in Cell.

The team used a virus called the murine leukaemia virus to produce mutations in cancer genes: the virus targets white blood cells, resulting in lymphoma, a common tumour of the blood system.

"Human cancers are generally thought to be formed by the stepwise accumulation of mutations that disrupt genes within a cell, and the virus mimics this process as it inserts itself into the mouse genome," explains Dr David Adams, senior author on the paper. "The virus then acts as a 'tag', allowing us to identify where it has integrated and which gene or genes have been disrupted.

"By finding an average of 20 mutations from each of the 500 tumours, not only did we find many new cancer genes, but we can see which genes work together in the same cell to transform it into a lymphoma." Said Dr. Jaap Kool, co-first author on the paper from the NKI.

The infected mouse lines carried mutations in genes called p53 and p19, which are known to suppress the development of cancer and are among the most commonly mutated genes in human cancers. The team were able to identify a rich set of novel genes implicated in cancer, including additional genes that might act to suppress tumour development, which are not readily detected in most surveys.

Human cancer cells frequently contain many mutations that are not involved in the development of cancer do not drive cancer development but are produced by increased mutation rates in cancer cells and are 'passengers'. Discerning which are driver and which are passenger mutations is a challenge for human cancer gene studies.

"The benefit of our system in the mouse is that, unlike human tumours, which usually contain many different types of genetic alternations, the causal mutations that initiate these tumours in mice can be easily identified and studied," explains Dr Adams, "These studies are complementary to and enrich the analysis of human cancers."

The project was made possible by the Sanger Institute's high-throughput sequencing and computational resources, which allowed the team to identify new potential cancer genes in the mouse. By comparing their data to genome-wide human cancer datasets generated by the Sanger Institutes' Cancer Genome Project, they could show that at some of the of the newly identified genes were potentially relevant to human cancer formation.

The team are currently carrying out other cancer screens using viruses and additional methods to disrupt cancer genes. These screens are searching for genes and gene interactions in the formation of bowel, lymphoid and breast cancers.


Contact: Don Powell
Wellcome Trust Sanger Institute

Related medicine news :

1. New England Technology Foundation Announces Connecting for Childrens Charities 2008 Event
2. Prescription for Change: New Survey Shows ePrescribing Connecting with its Biggest Skeptics ... Physicians
3. GigaLinx Unveils GEViewer(TM)- Industrys First Solution for Directly Connecting a GigE Camera to a Monitor
4. Drug therapy to bolster immune system cells found effective toward childhood cancer
5. Susan G. Komen for the Cure(R) Encourages Nation to Go Passionately Pink by Donning Pink, Donating Funds to End Breast Cancer Forever
6. Lowering Dietary Fat May Help Prevent Prostate Cancer
7. U of Minnesota researcher discovers the starting point of sun-induced skin cancer
8. Reducing intake of dietary fat prevents prostate cancer in mice
9. AUA 2008: Access to urologists and prostate cancer screenings lead to better outcomes for patients
10. Cool New Treatment for Hot Flashes in Breast Cancer Survivors
11. Cool new treatment for hot flashes in breast cancer survivors
Post Your Comments:
(Date:11/24/2015)... Los Angeles, CA (PRWEB) , ... November 24, 2015 , ... ... author explored the different restrictions and variables that determine which patients are or are ... are those patients that have a BMI over 40, are more than 100 pounds ...
(Date:11/24/2015)... ... November 24, 2015 , ... It takes only three to five seconds to ... that the first impression be positive and reflects business values. If a client starts ... or want to return. They will also share their thoughts about a business with ...
(Date:11/24/2015)... ... November 24, 2015 , ... Cancer patients, survivors, caregivers, ... at a live taping of the next CURE Connections® video series ... Cancers 2015 Symposium at Georgetown University Hotel & Conference Center in Washington, D.C. ...
(Date:11/24/2015)... ... November 24, 2015 , ... Aided by seed funding ... an innovative study designed to yield insights into how to detect and treat pancreatic ... for pancreatic cancer from small, non-coding RNA molecules (ncRNA), genetic material that is present ...
(Date:11/24/2015)... ... 24, 2015 , ... Sir Grout of Baltimore is proud ... The award recognizes good companies for excellence in service and a commitment to ... hard surface restoration company earned this recognition after a thorough review by the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... LONDON , November 24, 2015 ... PCSK9 Inhibitors, CETP Inhibitors, MTTP Inhibitors, ApoB Inhibitors and ... areas are going to grow at the fastest rates? ... to 2025, assessing data, trends, opportunities and prospects there. ... graphs. Discover the most lucrative areas in the industry ...
(Date:11/24/2015)... , UAE, November 24, 2015   ... and dietician deliver s advice and ...   More than 50% of ... to keep themselves healthy according to the DHA   femMED ... in the UAE    Dubai residents are not ...
(Date:11/24/2015)... , Nov. 24, 2015  Eyewear brand Revo ... collaboration with U2 lead singer and activist Bono as part ... prevent vision impairment and blindness in more than 5 million ... Revo will donate $10 from the sale of every ... up to a total of $10 million to the "Buy ...
Breaking Medicine Technology: