Navigation Links
Confronting the challenge of antimicrobial resistance
Date:3/10/2008

Drug resistance is making many diseases increasingly difficult--and sometimes impossible--to treat, according to Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Extensively drug-resistant tuberculosis and invasive methicillin-resistant Staphylococcus aureus (MRSA) infections are just two recent examples of this problem that pose serious threats to domestic and global health, he adds. In a new report in the Journal of Infectious Diseases, now available online, Dr. Fauci outlines NIAIDs commitment to addressing this urgent public health issue.

The innate ability of microbes to evade containment and destruction by drugs through rapid reproduction and genetic mutation is exacerbated by the overuse and misuse of existing antimicrobial drugs, Dr. Fauci and his coauthors note. Other factors contributing to the upswing in drug resistance include a dearth of rapid diagnostic tests that would allow physicians to better gauge whether a given infection is drug-susceptible or drug-resistant, and a paucity of clinical trial data to guide therapeutic strategies.

NIAID is meeting the complex challenge of antimicrobial resistance through a multifaceted research approach that includes partnerships with other federal agencies, academia, industry and non-governmental organizations, the authors report. In fiscal year 2007, NIAID invested more than $800 million to support basic and translational research on antimicrobials, more than $200 million of which was devoted to understanding the causes, consequences and treatments of antimicrobial drug resistance.

Basic research projects under way at NIAID or in NIAID-supported labs across the country include the following:

  • Investigations of mechanisms of resistance and how these traits are acquired and passed on by microbes
  • Research on factors that contribute to the virulence of pathogens such as MRSA
  • Efforts to better understand and ultimately prevent biofilms--slimy coatings made by communities of bacteria that are impervious to the effects of antibiotics
  • Creation of computer-based virtual microbial metabolic pathways that allow quick identification of potential drug targets

Facilitating the translation of basic research findings into better diagnostics, new therapies and novel strategies to slow the emergence of antimicrobial resistance is also an area of emphasis for the Institute, write the authors. The following are examples of the many applied and translational research programs supported by NIAID:

  • Numerous clinical trials, including is assessing the need for antibiotics in children with acute middle-ear infections; and two trials designed to test off-patent oral antibiotics for treating uncomplicated community-associated MRSA
  • Preclinical development of vaccine candidates to prevent staphylococcal infections
  • Efforts to improve diagnostics, particularly for healthcare-associated bacterial infections that are already or are likely to become drug-resistant, such as Clostridium difficile, Pseudomonas and Acinetobacter
  • DNA sequencing and other genomics resources that aid in discovery of diagnostics and therapeutics

Finally, the authors outline several new and established NIAID partnerships addressing antimicrobial resistance, including

  • The Federal Interagency Task Force on Antimicrobial Resistance, co-chaired by NIAID, the Centers for Disease Control and Prevention, and the Food and Drug Administration, which implements an annually updated action plan
  • The international Lilly Not-For-Profit Partnership for TB Early Phase Drug Discovery, which integrates the expertise of the pharmaceutical industry with university-based researchers to develop new drugs against TB, including multidrug-resistant and extensively drug-resistant forms of TB
  • A collaboration with the Novartis Institute for Tropical Diseases to advance new drugs to treat dengue fever

With antimicrobial resistance, we face the perpetual challenge of maintaining a favorable balance between microbes and humans, says Dr. Fauci. The efforts of NIAID and all our partners from the public health, research and pharmaceutical sectors are critical to addressing this challenge and thus keeping us at least one step ahead of our microbial foes.


'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. ADA Challenges Marylanders to Step Out to Fight Diabetes Epidemic
2. LifeQuest Announces End of Immunity Health Challenge Contest
3. Braun Challenges Business School Talent To Create A Buzz
4. Medifast Announces Winners of Mother-Daughter Challenge
5. The Fight for His Life: Author, Family Battle Disease and Challenge Politics in the Face of Survival
6. Genetics Hold Promise, Challenges for Cancer Care
7. Actavis Confirms its Patent Challenge of Kings Avinza(R)
8. Childhood Obesity Epidemic a Long-Term Challenge
9. Planning for 2020: increasing elderly population poses huge challenges in cancer care
10. Barr Confirms Patent Challenge of UROXATRAL(R)
11. The Challenge: Make It A Million (Pounds Lost That Is)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... corporate identity and website at its “Transforming Outcomes” User Conference in Las Vegas ... reflect i2i’s ongoing success to set the market standard for meaningful population health ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... of communication enabled solutions and managed services today announced a strategic partnership ... enterprise contact center market. , Altura, one of Avaya’s largest Platinum Business ...
(Date:5/24/2016)... Church, VA (PRWEB) , ... May 24, 2016 , ... ... 14-15, 2016 · Raleigh, NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known to ... is unlikely that human error will ever be totally eliminated, many human performance problems ...
(Date:5/24/2016)... ... ... Regenerative Medicine is being transformed by ongoing research and clinical findings at ... results as have been achieved with Okyanos Cell Therapy are paving the ... patients worldwide. , As the Medical Advisory Chairman at Okyanos, Eric Duckers, MD, PhD, ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... or injury that focuses on repairing the musculoskeletal and neuromuscular systems of the ... on functional restoration, NYDNRehab began providing treatments for physical therapy in New York, ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... médica para ayudar a los médicos a compartir sus ... pacientes a escala mundial. Profesionales médicos de Europa, África, ... se han apuntado a la aplicación, que combina la ... un entorno totalmente seguro. Educación   ...
(Date:5/24/2016)... May 24, 2016   , ... non-inferiority in overall bowel cleansing and superiority in ... leansing of the ... ) , Norgine B.V. today announced new positive data ... and ascorbate bowel preparation) versus standard 2 litre PEG with ascorbate. ...
(Date:5/24/2016)... Zealand , May 24, 2016 ... informatics solutions for the healthcare sector, has been named the ... Zealand Hi-Tech Awards 2016. Dr Bruce Davey ... acknowledgement for our team.  It,s really good to be recognised ... healthcare internationally. Our products are used in 35 countries around ...
Breaking Medicine Technology: