Navigation Links
Cone snails and plants used to develop oral drug for pain
Date:4/16/2008

Molecules from cone snail venom and African plants are being used by Queensland researchers as a blueprint to develop an oral drug to treat chronic pain.

Professor David Craik and Dr Richard Clark from the Institute for Molecular Bioscience have received $218,275 from the National Health and Medical Research Council (NHMRC) to aid in translating their research into a product available for Australians to use.

Studies on the molecule they have developed have shown that it is effective in relieving neuropathic pain in animals.

Neuropathic pain is one of the most severe forms of chronic pain, and very difficult to treat, Dr Clark said.

Regular pain occurs when the nervous system is stimulated by, for example, an injury, whereas neuropathic pain occurs when the nervous system itself is damaged.

Current treatments in neuropathic pain only provide meaningful relief for one in three patients, and all of the current market-leading drugs have serious side effects, as well as taking up to three weeks to begin to take effect.

Peptides (small proteins) from cone snail venom have attracted recent attention from scientists, as they can target receptors with a high degree of accuracy, thus eliminating severe side effects.

But peptides also degrade rapidly in the body. Professor Craik and Dr Clark have overcome this problem by engineering a circular peptide, using a circular protein backbone discovered by Professor Craik and found in plants such as violets.

The NHMRC Development grant will allow the researchers to further test their molecule to fully establish its therapeutic potential.

Successful outcomes from this project will provide additional confirmation of the suitability of our molecule as a treatment for neuropathic pain, Dr Clark said.

Armed with these data, we will be able to secure a commercial partner and develop this molecule into a tablet for sufferers of chronic pain.


'/>"/>

Contact: Bronwyn Adams
communications@uq.edu.au
61-733-462-134
Research Australia
Source:Eurekalert

Related medicine news :

1. New Technology Promises Safer Organ Transplants and Soft Tissue Surgeries
2. Lung transplants in cystic fibrosis patients with life-threatening bacteria sparks debate at ISHLT
3. Parkinsons Disrupts Stem Cell Therapy Transplants
4. Lung transplants not dangerous for children with cystic fibrosis, after all
5. Study shows lifetime effects of pediatric liver transplants
6. ABC and NMDP Partner to Meet Growing Need for Stem Cell and Cord Blood Transplants, Assure Funding for Cord Blood Network, Encourage Minority Donor Recruitment
7. New technique improves outcome for living donor liver transplants
8. New Interventional Radiology Treatment Shows Hope for People With Complications from Bone Marrow, Stem Cell Transplants
9. NIH grant to Emory and pediatric partners aims to improve kidney transplants for children
10. Boston Scientific Announces First European Implants of New Devices to Treat Heart Failure and Sudden Cardiac Death
11. Small-Diameter Dental Implants Increasingly Popular In the US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a ... today announced that its MyDario product is expected to appear on The ... when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz ... The ...
Breaking Medicine Technology: