Navigation Links
Concurrent chemo and radiation confers survival benefit in nasopharyngeal carcinoma patients
Date:11/4/2011

The combination of chemotherapy and radiation significantly improved the 5-year overall survival of patients with stage II nasopharyngeal carcinoma (NPC), according to a phase III study published Nov. 4 in the Journal of the National Cancer Institute.

Nasopharyngeal carcinoma is endemic in Southern China and Southeast Asia, where radiotherapy (RT) has been the primary treatment. Although the National Comprehensive Cancer Network (NCCN) recommends concurrent chemo-radiotherapy (CCRT) for stage II disease, evidence regarding its efficacy is weak, and this has not been defined as a primary endpoint in phase III trials.

To determine whether or not combined chemotherapy and radiotherapy confers survival benefit to stage II NPC patients, Qui-Yan Chen, M.D., Ph.D., of the Sun Yat-sen University Cancer Center in the People's Republic of China, and colleagues, conducted a phase III trial of patients randomly assigned to receive either radiation therapy (114 patients) or combined chemotherapy and radiation (116 patients).

They also found that after a median follow-up of 60 months, 22.8% of patients in the radiation group had disease progression, compared to 11.2% in the concurrent therapy group. The researchers found that 5-year overall survival, progression-free survival, and distant metastasis-free survival were statistically significantly higher in the concurrent therapy group compared with the group receiving radiation alone.

The authors conclude that based on the results of this trial, which they believe to be the first phase III trial to compare CCRT and RT, the NCCN guidelines are reasonable. They hypothesize that early-stage disease may have a smaller distant tumor bulk, and thus CCRT may be more effective in eradicating distant micro-metastases. Although patients in the combined therapy group experienced more toxic side effects than patients who only received radiotherapy, the regimen was overall well tolerated whe
'/>"/>

Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study introduces the prospect for concurrent antiangiogenic/antitumorigenic therapy
2. Concurrent chemo and radiation therepy improves long-term survival for inoperable stage III lung cancer
3. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
4. Roche/Genentech/Chugais Herceptin as an Add-On to Standard Chemotherapy Will Become Decision Resources Clinical Gold Standard in 2013 for the Treatment Of Gastric Cancer
5. Scientists identify microRNA as possible cause of chemotherapy resistance
6. Study evaluates costs and benefits of new chemotherapy drugs
7. Older Colon Cancer Patients Less Likely to Get Chemo
8. Are New Chemo Treatments Cost-Effective?
9. BioSphere Medical's HepaSphere Microspheres Safely Deliver Doxorubicin in Liver Cancer Chemoembolization Therapy -- Study Presented at SIR
10. Researchers find new chemotherapy combination shows promise in endometrial cancer
11. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Hopkins University School of Medicine researchers have been awarded ... diabetes, Novo Nordisk announced this month. Of the 110 ... Obesity Biologics Science Forum Program, only four projects were ... researchers. They are Jonathan Powell, M.D., Ph.D.; G. William ... Jonathan Powell, a professor of oncology, will use his ...
(Date:4/18/2014)... 18, 2014) ― A new study in the ... in health-related Google searches reveals a recurring pattern that ... , Investigators from San Diego State University, the ... Campaigns, analyzed "healthy" Google searches (searches that included the ... originating in the U.S. from 2005 to 2012. They ...
(Date:4/17/2014)... non-cancerous prostate tissue may have nearly twice the risk ... inflammation, according to results of a new study led ... , The link between persistent inflammation and cancer was ... those with a Gleason score between 7 and ... and rapidly growing prostate cancers. , "What we,ve shown ...
(Date:4/17/2014)... today in PLOS Pathogens , children who live ... can mount an immune response to infection with malaria ... of high fever and illness and partially control the ... may help researchers develop future interventions that prevent or ... Each year, approximately 200 million cases of malaria occur ...
(Date:4/17/2014)... published in the April issue of Immunity , ... for Medical Research, says it,s time to take a ... treating sepsis, which kills millions worldwide every year, ... molecules released into the bloodstream to fight an injury ... necessary for maintaining good health without inflammation, wounds ...
Breaking Medicine News(10 mins):Health News:New research shows people are thinking about their health early in the week 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2
... new study has indicated the steps by which an breastfeeding women ... have shown that the overweight women who are breastfeeding and want ... amount of sweetened drinks, snack foods, sweets and desserts in their ... for 45 minutes per day, for at least four days in ...
... Vermont say that drinking cherry juice may be the antidote ... and anti-inflammatory compounds that can deal with a number of ... of Sports Medicine, researchers said that men and women who ... markers in their blood. The study examined 14 male college ...
... after menopause could increase the risk of breast cancer, says a ... studied over 87,000 women, aged 30 to 55 years for up ... noted how it had changed since, reported the online edition of ... through menopause during the course of the study were also assessed ...
... Organization has communicated to countries the benefits of building up ... companies have sent in their request// to Roche AG, the ... combat a potential bird-flu pandemic. ,Though U.S ... yet they have enabled companies a list of things to ...
... have their say on whether patients should have to opt ... medical profession is concerned that, in the proposed summary care ... the patient, and this is not being made sufficiently clear ... in a letter to this week's journal. ,"Patients ...
... the debate with many others to discuss on the focus ... women.// Instead of giving a conceptual argument on the similarities ... and proved. ,Barres' experience as a female-to-male transgendered ... July 13 issue of Nature rebuking the comments of former ...
Cached Medicine News:Health News:Diet & Exercise regime Not Harmful For Overweight, Lactating Mothers Or their Infants 2Health News:Electronic Patient Record "Serious Threat" to Patient Confidentiality 2Health News:Transgender Experience - A Tool to Analyze Gender Difference By Stanford Scientist 2Health News:Transgender Experience - A Tool to Analyze Gender Difference By Stanford Scientist 3Health News:Transgender Experience - A Tool to Analyze Gender Difference By Stanford Scientist 4
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its Israeli ... sophisticated agro-breeding solutions for plant breeders and researchers, today ... of directors appointed chemistry and pharmaceutical industry expert Dr. ... the board. From 1975 to 2012, Dr. ...
(Date:1/15/2014)...  Echo Therapeutics, Inc. (Nasdaq: ECTE ) ("Echo"), ... as a non-invasive, wireless continuous glucose monitoring system, today ... and Interim CEO of Echo Therapeutics, will present at ... Mr. Doman will make a corporate ...
(Date:1/15/2014)... 15, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... offer by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ... stock of Solta Medical, Inc. (NASDAQ: SLTM ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... MORRISVILLE, N.C., Sept. 11 Clinical Logistics is pleased to announce ... Corporation (Gentris), a GLP compliant laboratory, located in Morrisville, North Carolina. ... DNA, RNA, whole blood, FFPE tissue blocks, urine, plasma, serum, saliva, ... storage conditions is available: , , ...
... YORK, Sept. 11 /PRNewswire-FirstCall/ - (OTCBB: GVBP.OB) - GENova ... method for destroying breast cancer cells, using stem cell ... that enables us to identify the protein expression in ... tumors. This ability to identify the molecular markers of ...
Cached Medicine Technology:Clinical Logistics Enters Partnership with Gentris Corporation 2New stem cell identification technology could cure breast cancer 2
... Nephew ECTRA II systems permit the surgeon ... ligament endoscopically, allowing access via two portals ... endoscopic lens fogging with good air flow. ... and control. ECTRA knives permit the surgeon ...
... Screw System provides a unique option for the ... particularly the opening wedge osteotomy of the first ... Fragment Plate and Screw Set is a complete ... houses the plates, screws, and drills. It provides ...
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
Medicine Products: