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Concomitant use of Perforomist & tiotropium -- significant improvements -- COPD
Date:5/20/2008

Shortness of breath, chest tightness, nighttime awakenings, and total symptom scores all improved significantly with the Perforomist/TIO treatment compared with TIO/placebo (p<0.05). Cough scores did not differ between groups. Albuterol use declined in the Perforomist/TIO group from 2.4 to1.3 puffs/day and increased in the TIO/placebo group from 2.8 to 3.4 puffs/day over six weeks; another statistically significant difference (p< 0.0001). SGRQ total scores did not change markedly from baseline or differ between groups except for the symptom domain score, which was superior in the Perforomist/TIO group compared to TIO/placebo (-6.3, p<0.04).

DEY is very pleased with the results of this study and the benefit that patients are seeing with Perforomist Inhalation Solution, said Carolyn Myers, Ph.D., President of Dey, L.P. We wish to thank Dr. Tashkin and the other members of the research team for their careful investigation into the clinical benefits of concomitant therapy of Perforomist and tiotropium. At DEY, we are committed to developing effective new treatments for serious and complex diseases, and with Perforomist are proud to provide physicians and patients a twice-daily COPD maintenance medication that offers the flexibility of dosing via nebulization.

For those attending ATS 2008, the presentation is available as follows:

Poster viewing: Session ID C42 COPD Pharmacotherapy I: Effects of Bronchodilators Tuesday, May 20, 2008, 10:45 a.m. 12:30 p.m. EDT Metro Toronto Convention Center; Area F: Halls A-B North Building, Level 300

Poster # F4: Addition of Nebulized Formoterol Fumarate to Tiotropium Treatment Relieves Dyspnea and Symptoms in COPD Patients


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Contact: Amy Techtmann
amy.techtmann@fkhealth.com
617-761-6784
Feinstein Kean Healthcare
Source:Eurekalert

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