Concern From Doctors Regarding the Cardiovascular Safety of GlaxoSmithKline's Avandia Increases Nine-Fold Following Publication of Met... ( Nearly Three-Quarters of Physician...)

HOME >> MEDICINE >> NEWS

Concern From Doctors Regarding the Cardiovascular Safety of GlaxoSmithKline's Avandia Increases Nine-Fold Following Publication of Meta-Analysis

Date:4/22/2008

Nearly Three-Quarters of Physicians Have Switched Patients to Merck's

Januvia, According to a New Report from Decision Resources

WALTHAM, Mass., April 22 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that the percentage of primary care physicians (PCPs) and endocrinologists who consider the cardiovascular safety of GlaxoSmithKline's Avandia to be a major concern increased more than nine-fold following publication of a meta-analysis. Published in May 2007 by Steve Nissen in the New England Journal of Medicine, the meta-analysis calls into question the cardiovascular safety of Avandia and features analysis of data from several different trials showing that the drug increases the risk of myocardial infarction by 43 percent. Prescriptions for Avandia dropped significantly in the weeks following publication of the meta-analysis. According to the new Physician and Payer Forum report entitled Avandia One Year Later-A Physician and Payer Perspective, the full impact of the meta-analysis on Avandia prescribing has not yet been felt. 58 percent of PCPs and 52 percent of endocrinologists say they will reduce their prescribing of Avandia over the next year.

The report also finds that nearly three-quarters of physicians say they have switched patients to Merck's Januvia as a result of the Avandia meta-analysis. More than 80 percent of surveyed physicians say they will increase the number of total prescriptions they write for Januvia over the next two years. Although clinicians and managed care organizations surveyed consider metformin (Bristol-Myers Squibb's Glucophage, generics) to offer the best overall safety and efficacy, Januvia received the second greatest number of votes for "agent with the best overall safety profile" and for "lowest risk of hypoglycemia." In comparison, Amylin/Eli Lilly's Byetta was chosen by endocrinologists and MCOs as the agent
'/>"/>

SOURCE Decision Resources
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3
Related medicine news :

1. Wal-Mart & Nalgene Removing Toxic Bottles, Place Consumers Concerns First
2. 18th Annual Retirement Confidence Survey:(R) Workers Show Record Drop in Retirement Confidence, Health Care and Economy Are Major Concerns
3. Operating Room Nurses are Concerned about Complications Associated with Powdered Gloves
4. Genaera Corporation Receives Audit Opinion Containing Going Concern Explanatory Paragraph
5. Iomai Reports Going Concern Qualification in 10-K
6. CryoCor Reports Going Concern Statement and Receives Notification From Nasdaq Relating to Minimum Stockholders Equity
7. Talent Shortage Emerges as No. 1 Employer Concern: Deloitte/ISCEBS
8. National Religious Coalition Deeply Concerned by HHS Secretarys Disregard for Womens Reproductive Health
9. Project Concern International Receives a US$1 Million Grant From the Starbucks Foundations Ethos Water Fund to Provide Safe Water and Sanitation Services in Tanzania
10. Bi-Partisan Members of United States Senate Formally Raise Concerns About Proposed Cuts to Medicares Home Oxygen Benefit
11. TransUnion Addresses Ohio Attorney Generals Concerns Surrounding Non-Profit Tax-Exempt Status

Post Your Comments:

(Date:11/21/2008)...Mass., Nov. 21 Cardiosolutions, In...unced the appointment of Dr. Lars,Svensson, M.D.,...Dr. Svensson,is currently the Director of the Cen... Syndrome and Connective Tissue Disorder Clinic in...rgery at Cleveland Clinic. , Cardiosolution...

(Date:11/21/2008)... New data presented at the 61st Annu...y of America showed JANUVIA™ (sitagliptin), ...gnificantly reduced blood sugar levels in elderly ...ed with hypoglycemia (low blood sugar). In this st...e no reports of hypoglycemia in either the JANUVIA...

(Date:11/21/2008)..., Nov. 21 Unilens Vision...hange: UVI), which develops, licenses,manufactur...es, today reported,its operating results for the ..., Net sales, excluding royalty income, incre...compared with $1,673,361 in the previous year firs...

(Date:11/21/2008)...v. 21 Attorneys representing consu...posed landmark $350 million settlement,with healt...ttle allegations the,company fraudulently inflate...,manipulating drug-pricing benchmarks. , (...7/AQM144LOGO ) , The lawsuit, filed under t...

[0] Cardiosolutions Names Dr. Lars Svensson Chief Surgical Officer [0] New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes [0] Unilens Vision Reports Record First Quarter Revenue, Earnings and Royalty Income [0] Hagens Berman Sobol Shapiro: McKesson Settles RICO Lawsuit for $350 Million

...ification of a new biochemical switch that affects...d with learning could pave way for better understa... A protein named “ Reelin”, an important componen... focus of the research. During development, reelin...

... cells are truly a marvel. Yes! It has been proven...have used fetal skin cells to successfully heal yo... revolutionary procedure avoids the need to remove...he skin cells that are taken from an aborted fetus...

...isk of developing inflammatory disorders like rheu...ghtly-coloured fruits and vegetables like oranges,...nt beta-cryptoxanthin, both of which are found in ...g, may act as antioxidants, and protect the body a...

...he first time, a gene linked to the disease tuberc...ol the onset of the disease. The gene NRAMP1 is kn...ike leprosy // and rheumatoid arthritis. Different...he speed at which tuberculosis develops. Certain f...

Other Medicine News:Health News:Learning process to be regulated by altering brain protein 2

Learning process to be regulated by altering brain protein Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help Arthiritis: Brightly-coloured fruit and vegetables offer protection Gene Target For Tuberculosis Identified

(Date:11/18/2008)...wire/ -- Arlington Medical Resources (AMR), a,pro...aceutical and diagnostic,imaging industries, find...was,sold in the U.S. during the third quarter of ... immune globulin (IVIG) and was launched in the fi...om the blood plasma of thousands,of donors and is...

(Date:11/18/2008)...008 Faces of Influenza survey underscores that mot...nza; Mother and Gold Medalist Kristi Yamaguchi joi...ewswire/ -- While 78 percent of mothers in the Uni...ally life-threatening disease that can strike anyo... get vaccinated this season, according to a new su...

(Date:11/13/2008)...PRNewswire-FirstCall/ -- Hologic, Inc.,(Nasdaq: H...ier of premium,diagnostics, medical imaging system...ealthcare needs of women, today announced the resu... trial. The Cervista HPV high-risk,test is current...cted to be,launched in the European Union (EU) ear...

(Date:11/13/2008)...inds Statins Cut Risk of Heart Attacks, Deaths, R...diovascular Disease,is the leading cause of death ...dreds of millions of dollars and causing untold su... fatal disease - even among those who,weren,t thou...llions of people could cut their risk of a,heart a...

Breaking Medicine Technology:Over $10 Million of CSL Behring's Privigen Was Sold in the U.S. During the Third Quarter of 2008 2 Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 2 Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 3 Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 4 Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 5 Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 6 Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials 2 Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials 3 Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials 4 Seniors Can Be Heartened by New Study on Statins 2 Concuity Announces the Availability of PriceAdvisor 22615 1 Concuity Announces the Availability of PriceAdvisor 22615 2 Concuity Announces the Availability of PriceAdvisor 22615 3 Concuity Announces the Availability of PriceAdvisor 22615 4 Night Hospitalist Company LLC Launches First Nighttime Hospitalist Telemedicine Solution 22612 1 Night Hospitalist Company LLC Launches First Nighttime Hospitalist Telemedicine Solution 22612 2 HealthPartners Medical Group in Michigan City purchases IDC digital radiography system 22609 1 HealthPartners Medical Group in Michigan City purchases IDC digital radiography system 22609 2 HealthPartners Medical Group in Michigan City purchases IDC digital radiography system 22609 3 Keryx Biopharmaceuticals to Present at the Jefferies 26 Co Healthcare Conference 6180 1 Keryx Biopharmaceuticals to Present at the Jefferies 26 Co Healthcare Conference 6180 2

[0] Over $10 Million of CSL Behring's Privigen Was Sold in the U.S. During the Third Quarter of 2008 [0] Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated [0] Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials [1] Seniors Can Be Heartened by New Study on Statins

...gy Compounds at the,American Association for Cance...l 13, 2007 /PRNewswire-FirstCall/ -- For,decades, ...et,cancer. Researchers now know that cancer cells ...e new blood vessels to deliver oxygen,and nutrient...eration), they travel throughout the body (metasta...

...irstCall/ -- VION,PHARMACEUTICALS, INC. announced ...tazine(R) (VNP40101M) will be presented in,posters...iation of,Cancer Research in Los Angeles, Californ...website, <a target="_blank" href=,"http://www.vion...ntation. , All posters will be presented in the Lo...

Other Medicine Technology:Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer 2 Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer 3 Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer 4 Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual,Meeting of the American Association of Cancer Research (AACR) 2 Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual,Meeting of the American Association of Cancer Research (AACR) 3 Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual,Meeting of the American Association of Cancer Research (AACR) 4

Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual,Meeting of the American Association of Cancer Research (AACR)

...RUP Laboratories is a national reference laborator...research and development. ARUP offers an extensive...sts in clinical and anatomic pathology. Owned by t...include more than half of the nation's university ...

Medicine Products:

Acanthamoeba Stain Absolute Eosinophils Count ABO-Rh Prenatal AAT

Concern From Doctors Regarding the Cardiovascular Safety of GlaxoSmithKline's Avandia Increases Nine-Fold Following Publication of Met...( Nearly Three-Quarters of Physician...),Health