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Conceptualizing cancer cells as ancient 'toolkit'
Date:2/7/2011

ies. "In that sense, cancer is an accident waiting to happen."

If Davies and Lineweaver are correct, then the genomes of the simplest multicellular organisms will hide clues to the way that cancer evades control by the body and develops resistance to chemotherapy. And their approach suggests that a limited number of genetic pathways are favored by cells as they become progressively genetically unstable and malignant, implying that cancer could be manageable by a finite suite of drugs in the coming era of personalized medicine.

"Our new model should give oncologists new hope because cancer is a limited and ultimately predictable atavistic adversary," says Lineweaver. "Cancer is not going anywhere evolutionarily; it just starts up in a new patient the way it started up in the previous one."

The authors also believe that the study of cancer can inform astrobiology. "It's not a one-way street," says Davies. "Cancer can give us important clues about the nature and history of life itself."


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Contact: Carol Hughes
carol.hughes@asu.edu
480-965-6375
Arizona State University
Source:Eurekalert

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