Navigation Links
Computer algorithms help find cancer connections
Date:5/1/2013

PROVIDENCE, R.I. [Brown University] Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer.

In a study reported today in the New England Journal of Medicine, researchers from Washington University in St. Louis used two algorithms developed at Brown to assemble the most complete genetic profile yet of acute myeloid leukemia (AML), an aggressive form of blood cancer. The researchers hope the work will lead to new AML treatments based on the genetics of each patient's disease.

The algorithms, developed by Ben Raphael, Eli Upfal, and Fabio Vandin from the Department of Computer Science and the Center for Computational Molecular Biology (CCMB), played a key role in making sense of the giant datasets required for the study. The work was part of The Cancer Genome Atlas project, which aims to catalog the genetic mutations that cause cells to become cancerous. Doing that requires sequencing the entire genome of cancer cells and comparing it to the genome of healthy cells. Without computational tools like the ones the Brown team has developed, analyzing those data would be impossible.

The AML study used two algorithms developed by the Brown team: HotNet and Dendrix. Both aim to find networks of genes that are important in creating cancerous cells. To understand how they work and why they are important, it helps to know a little about the genetics of cancer.

"Genes don't usually act or their own, but instead act together in pathways or networks," said Raphael, associate professor computer science. "Cancer-causing mutations often target these networks and pathways." This presents a problem for researchers trying to find important mutations, because these mutations are often spread across the network and hidden in the genetic data.

Imagine a cellular pathway containing five genes. If any one of those genes acquires a mutation,
'/>"/>

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Are Pricey Computer-Aided Mammograms Worth It?
2. Atlanta LASIK Surgeon Interviewed About Computer Vision Syndrome Prevention
3. Watson, IBM'S Supercomputer is Now Programmed to Recommend Perispinally Administered Etanercept as an Alzheimer's Disease Treatment
4. Study: Computerized reminders significantly improve HIV care in resource-limited setting
5. Could a computer on the police beat prevent violence?
6. Can computers save health care? IU research shows lower costs, better outcomes
7. YogaDownload and YogaFit® Team Up to Bring World’s Largest Yoga Fitness School Straight to Your Computer
8. Phoenix Synergy Discusses securing computer networks at the AZPMA conference in Las Vegas
9. Mobile Computer Cart Rental Program Launched by Add-On Data
10. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
11. Dr. Michael Reiss of Southern Nevada Chiropractic Helps Car Accident Patients with Neck or Back Pain by Providing Computerized Spinal Exam and a Copy of His Book
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Ticket Down is a reliable source for ... the Sports Authority Field on July 26th. For the past four ... some of the best club teams from around the world to ... raved about weeks after its completion, fans – new and old ... biggest stars in the world compete. Some of these players were ...
(Date:7/24/2014)... The report, “Content Delivery Networks ... into various sub-segments with an in-depth analysis and ... and restraints for this market with insights on ... data tables and 36 figures spread through 157 ... (CDN) Market” at http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . , ...
(Date:7/24/2014)... 2014 The federal judge overseeing ... in the U.S. District Court, District of Massachusetts, ... medical information covered by the federal Health Insurance ... 16th Order, U.S. District Judge Douglas P. Woodlock ... Care the right to receive HIPAA- protected information. ...
(Date:7/24/2014)... In a July 9th article in the Money magazine ... Blossom Consulting LLC , was quoted in a Family Finance ... the High Cost of Infertility . Her advice began with, ... your chance of success from the first attempt.” The article ... “I am always happy to talk with the media about ...
(Date:7/24/2014)... of Association Executives (ASAE) announced its 2014 Power of ... American Society of Anesthesiologists (ASA). , The ASA ... A Gold Award, one of the top honors from ... of the world through education on the global anesthesia ... care. , ASA was also honored with a Power ...
Breaking Medicine News(10 mins):Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3
... HealthDay Reporter , TUESDAY, Jan. 25 (HealthDay News) -- Following ... and Drug Administration is asking an expert panel to vote ... standards. Over the past five years, there have been ... a patient in cardiac arrest in hopes of getting the ...
... which was conducted at Sahlgrenska University Hospital in Gothenburg ... the ages of 18 and 65. Half the group ... the other half to maintain their usual lifestyle. ... The active group increased their physical activity on their ...
... is projected by the U.S. Census Bureau that by the year ... 70 million in the U.S. alone, and more than one billion ... experience at least one disorder of the pelvic floor in her ... teamed up with practitioners across the state to create the Rhode ...
... Scientists studied the defences used by caterpillars that transform ... insects regurgitate semi-digested cabbage leaves to make them smell ... however, that frequent use of this defence reduces the ... produce. It remains unclear why their defences affect ...
... January 25, 2011 (Toronto) A workplace,s key employees may ... work stress, according to a new study by the Centre ... of 2,737 workers, 18 per cent reported that their job ... stress were greater if workers were managers or professionals, if ...
... -- For many people, their communication skills with loved ... In fact, spouses sometimes communicate with each other no ... "People commonly believe that they communicate better with ... people to overestimate how well they communicate, a phenomenon ...
Cached Medicine News:Health News:FDA Looking for Tougher Standards for External Defibrillators 2Health News:Women & Infants launches Rhode Island Network for Pelvic Floor Disorders 2Health News:Insects that deter predators produce fewer offspring 2Health News:Workers most invested in their jobs have highest stress levels, CAMH study shows 2Health News:Close Relationships Sometimes Mask Poor Communication 2
(Date:7/24/2014)... HILDEN , Deutschland, und ... , ... ermöglicht QIAGEN die Entwicklung von ... Genpanels, für Blutkrebs  Neuer Test ... Patienten mit Knochenmarkserkrankungen (myelodysplastischen Syndromen) einen günstigen ...
(Date:7/24/2014)... MOUNTAIN VIEW, Calif. , July 24, 2014 /PRNewswire/ ... that it will release its second quarter 2014 financial ... 31, 2014. In conjunction with the release, the ... community at 5:00 p.m. Eastern Time on ... results of the quarter and other business developments. ...
(Date:7/24/2014)... and MENLO PARK, Calif. , July 24, ... ("DelMar" "the company") announced today that the company,s board of ... December 31 to June 30. Accordingly, DelMar will file a ... Jeffrey Bacha , president and CEO of DelMar ... step in achieving our goal of obtaining a senior exchange ...
Breaking Medicine Technology:QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 3QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 5DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 2DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 3
... (Nasdaq: BMRN ) today announced that Jean-Jacques Bienaime, ... at the Wedbush Life Sciences Conference in New York on ... Interested parties may access a live audio webcast of the ... www.BMRN.com .  A replay of the call will be ...
... Merck,s Schering-Plough unit current and former pharmaceutical representatives ... opinion issued by a Federal Court in Connecticut. ... The law firms of Joseph, Herzfeld, Hester ... represent the plaintiffs in a Nationwide Collective Law Suit. ...
Cached Medicine Technology:BioMarin to Present at the Wedbush Life Sciences Conference 2UPDATE: Total Victory for Schering-Plough (Now Merck) Pharmaceutical Reps in National Suit for Overtime Pay 2
... Hand Implant System utilizes the same proven ... replacements. The SR™ Hand Implant System ... prostheses including minimal bone resection, surface replacement ... surfaces, retention and/or repositioning of the ligamentous ...
... the NeuFlex™ MCP and/or PIP ... on numerous research studies of ... the MCP/PIP joint. This prosthesis ... the phalanx, by settling the ...
... Blackstone Anterior Cervical Plate System ... implantation. The innovative design of ... prevents screw back-out. The implant ... Simple, reliable instrumentationincluding innovations like ...
... closely match the natural anatomy of ... Titanium construction incorporates an 8-degree cranial ... design prevents screws from backing out. ... for X-ray control of the procedure. ...
Medicine Products: