Navigation Links
Computer algorithms help find cancer connections
Date:5/1/2013

PROVIDENCE, R.I. [Brown University] Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer.

In a study reported today in the New England Journal of Medicine, researchers from Washington University in St. Louis used two algorithms developed at Brown to assemble the most complete genetic profile yet of acute myeloid leukemia (AML), an aggressive form of blood cancer. The researchers hope the work will lead to new AML treatments based on the genetics of each patient's disease.

The algorithms, developed by Ben Raphael, Eli Upfal, and Fabio Vandin from the Department of Computer Science and the Center for Computational Molecular Biology (CCMB), played a key role in making sense of the giant datasets required for the study. The work was part of The Cancer Genome Atlas project, which aims to catalog the genetic mutations that cause cells to become cancerous. Doing that requires sequencing the entire genome of cancer cells and comparing it to the genome of healthy cells. Without computational tools like the ones the Brown team has developed, analyzing those data would be impossible.

The AML study used two algorithms developed by the Brown team: HotNet and Dendrix. Both aim to find networks of genes that are important in creating cancerous cells. To understand how they work and why they are important, it helps to know a little about the genetics of cancer.

"Genes don't usually act or their own, but instead act together in pathways or networks," said Raphael, associate professor computer science. "Cancer-causing mutations often target these networks and pathways." This presents a problem for researchers trying to find important mutations, because these mutations are often spread across the network and hidden in the genetic data.

Imagine a cellular pathway containing five genes. If any one of those genes acquires a mutation,
'/>"/>

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Are Pricey Computer-Aided Mammograms Worth It?
2. Atlanta LASIK Surgeon Interviewed About Computer Vision Syndrome Prevention
3. Watson, IBM'S Supercomputer is Now Programmed to Recommend Perispinally Administered Etanercept as an Alzheimer's Disease Treatment
4. Study: Computerized reminders significantly improve HIV care in resource-limited setting
5. Could a computer on the police beat prevent violence?
6. Can computers save health care? IU research shows lower costs, better outcomes
7. YogaDownload and YogaFit® Team Up to Bring World’s Largest Yoga Fitness School Straight to Your Computer
8. Phoenix Synergy Discusses securing computer networks at the AZPMA conference in Las Vegas
9. Mobile Computer Cart Rental Program Launched by Add-On Data
10. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
11. Dr. Michael Reiss of Southern Nevada Chiropractic Helps Car Accident Patients with Neck or Back Pain by Providing Computerized Spinal Exam and a Copy of His Book
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 Rockynol Retirement Community ... on Oct. 14. The $11 million project will include ... a cooked-to-order kitchen with full-service restaurant style dining. , ... for first class Assisted Living apartments,” said Kara Hanzie, ... the highest quality of care and this investment is ...
(Date:10/20/2014)... 20, 2014 National Teen Driver Safety Week ... American Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) is ... parents of teen drivers to talk to their teens and ... Motor vehicle crashes are the leading cause of death for ... in fatal crashes, and 859 (42%) of those teen drivers ...
(Date:10/20/2014)... 2014 It’s hard to imagine what it’s ... vulnerable children around the world, it’s a reality. And while ... children are forced to walk barefoot on rocky terrain or ... play with their friends. , Buckner International's Shoes ... Radio in October to encourage support for Air1 and ...
(Date:10/20/2014)... Spring, Maryland, USA (PRWEB) October 20, 2014 ... or to track interventions? Here comes a wonderful app ... mobile app development company helped its client ... Intervention more efficiently. The app is designed for iOS ... and iPod touch. This app is optimized for iPhone ...
(Date:10/19/2014)... Recently, BambooIndustry.com, one of the most popular ... of bamboo deckings . Moreover, the company has ... are now available at deeply discounted rates. , ... to overstate the significance of online business nowadays. Thus, ... The company’s workers are striving to deliver both value ...
Breaking Medicine News(10 mins):Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2
... - Contract Extended One Year -LEXINGTON, Mass., Jan. ... MedAssets Supply Chain Systems has extended its contract ... 2010. This continues a successful history between ... in 2002.The contract covers IL,s portfolio of critical ...
... Medimetriks Pharmaceuticals announced today that the Company ... (Nasdaq: PRGO ), a leading manufacturer in ... Authorized Distributor of generic versions of Medimetriks, branded products ... to receive a percentage of Perrigo,s Net Sales on ...
... HEIGHTS, N.J., Jan. 26 Authentidate Holding Corp. ... of secure Health Information Exchange and workflow management ... from representatives of Parascript, LLC and Parascript Management, ... Agreement and Plan of Merger it entered into ...
... standards snag company awardIRVINE, Calif., Jan. 26 ... in phytochemical reference standards and contract research, announced ... natural products and alternative health care magazine, selected ... Scientific Achievement Award recipients for its achievement in ...
... 26 Trintech Group Plc (Nasdaq: TTPA ... transaction risk management, and compliance solutions, today announced that ... meet on January 27 in Mountain View, California as ... share common experiences, discuss the latest market trends and ...
... announced,that it has launched the International College ... surgical teams from around the world.,The launch was announced ... San Francisco. , "We have ... we began our program in 2002," says Kirk Wilson, ...
Cached Medicine News:Health News:Instrumentation Laboratory Wins Extended Agreement With MedAssets Supply Chain Systems for Critical Care Portfolio 2Health News:Instrumentation Laboratory Wins Extended Agreement With MedAssets Supply Chain Systems for Critical Care Portfolio 3Health News:Perrigo Company Appointed Generic Distributor by Medimetriks Pharmaceuticals 2Health News:Perrigo Company Appointed Generic Distributor by Medimetriks Pharmaceuticals 3Health News:Authentidate Announces Termination of Merger Agreement With Parascript, LLC 2Health News:Authentidate Announces Termination of Merger Agreement With Parascript, LLC 3Health News:ChromaDex Awarded Nutrition Business Journal Scientific Achievement 2Health News:KPMG and Trintech Collaborate to Enable Bay Area Users Group of Trintech Customers to Optimize Their Investments in Technology and Deliver Improved Performance in Turbulent Economic Times 2Health News:KPMG and Trintech Collaborate to Enable Bay Area Users Group of Trintech Customers to Optimize Their Investments in Technology and Deliver Improved Performance in Turbulent Economic Times 3Health News:Saint Joseph's Launches International College of Robotic Surgery 2
(Date:10/18/2014)... 18, 2014  In a policy paper ... the nation,s largest lesbian, gay, bisexual and transgender ... of Truvada for Pre-Exposure Prophylaxis (PrEP). PrEP is ... prevent the spread of a disease or infection ... name anti-HIV drug combination currently approved for PrEP, ...
(Date:10/17/2014)... NORWALK, Conn. , Oct. 17, 2014 UBM ... , a leading online community and information resource for ... Parkinson disease and Alzheimer disease , with discussions ... Up to 1 million Americans have Parkinson disease , ... muscular dystrophy, or Lou Gehrig disease. Diagnosis can ...
(Date:10/17/2014)... 17, 2014 A victim of medical negligence at ... doctor with a history of alcohol abuse, a physician and ... Prop 46 today, highlighting how Prop 46 will identify and ... The ad pictures a doctor drinking at ... ER."  Proposition 46 will enact the first law in the ...
Breaking Medicine Technology:HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4
... of facial acne scars showed greater improvement with a ... induction (PCI or medical needling) with the ... , The results of the pilot split-face comparison were ... ENVIRON® distributor DermoGenesis , at the ...
... Pharmaceuticals, Inc. (Nasdaq: BCRX ) today announced that Jon ... Stuart Grant, Chief Financial Officer of BioCryst, plan to provide ... in New York on Tuesday, October 6, 2009 at 3:30 ... Web cast and replay of the presentation may be accessed ...
Cached Medicine Technology:Acne Scars Significantly Improved by a Combination Treatment of Photodynamic Therapy and Percutaneous Collagen Induction 2BioCryst to Present at JMP Securities Healthcare Conference 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: