Navigation Links
Computer 'Pathologist' Could Help Assess Breast Cancer Survival
Date:11/9/2011

By Kathleen Doheny
HealthDay Reporter

WEDNESDAY, Nov. 9 (HealthDay News) -- A new computer model analyzes microscopic breast cancer images and predicts patient survival better than the pathologists who do the job now, new research suggests.

The computer program "provides information above and beyond what the physician provides, using the same data," said Daphne Koller, a professor of computer science at Stanford University and senior author of the study. The computer model is called Computational Pathologist, or C-Path.

Although the technique needs much more study, it may someday supplement analysis of breast cancer by pathologists, who use a process that has remained largely unchanged for 80 years, said Koller.

With the traditional method, pathologists examine a tumor visually under a microscope and score it according to an established scale. The scores help doctors figure out the type and diversity of the cancer. From that information, they calculate the outlook and course of treatment.

The pathologists' determination relies on three factors: what percent of the tumor is made up of tube-like cells; the diversity of the nuclei in the outer cells; and how often those cells divide.

But the system is subjective, said the study authors, whose computer model found that additional factors may influence survival. The study is published Nov. 9 in Science Translational Medicine.

Using the C-Path image analysis program, Koller's team trained the computer to analyze biopsied breast cancer tissue and to determine the cancer features that matter most and least in predicting survival.

The computer model looked at more than 6,000 cellular factors and found that characteristics of the cells surrounding the cancer -- the cancer's environment -- are also important in predicting survival.

"We found 11 [factors] ultimately that showed the most robust association with survival," said Dr. Andrew H. Beck, an assistant professor of pathology at Harvard Medical School, in Boston. He is the lead author of the study, done while he was a doctoral student at Stanford School of Medicine.

The researchers applied the C-Path system to images from two groups of patients with breast cancer. One group, from the Netherlands, included 248 people. The other, from Vancouver, Canada, had 328 patients.

The prognostic score generated by C-Path was strongly associated with survival in both groups, Koller said. The groups predicted to be high risk by C-Path were more likely to die in a given year than those predicted to be low risk, she said.

C-Path would help, not replace, pathologists. "We see it ultimately as a complementary approach," said Beck.

Neither Stanford nor the researchers has begun commercial development of the method, Koller said.

In a commentary accompanying the study, Dr. David L. Rimm, professor of pathology at Yale University School of Medicine, called the research ''landmark" work.

"C-Path potentially is the first truly objective, quantitative grading system for cancerous tissue and its surrounding stroma [connective tissue]," he writes.

However, Rimm and other experts agreed that further research is needed. "This isn't quite ready for prime time," he said.

Dr. Anil V. Parwani, a pathologist and division director of pathology informatics at the University of Pittsburgh Medical Center, said: "It (C-Path) has interesting potential and provides a novel look. The results are interesting, but the study is limited."

More information

To learn more about breast cancer, visit the College of American Pathologists.

SOURCES: Daphne Koller, Ph.D., Rajeev Motwani professor of computer science, Stanford University, Stanford, Calif.; Andrew Beck, M.D., assistant professor of pathology, Harvard Medical School, Boston; David L. Rimm, professor of pathology, Yale University School of Medicine, New Haven, Conn.; Anil V. Parwani, Ph.D.,divisional director, pathology informatics, University of Pittsburgh Medical Center; Nov. 9, 2011 Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford team trains computer to evaluate breast cancer
2. Wayne State creating computer-based drug intervention for at-risk post-partum women
3. Computer-based tool to improve diagnosis and prognosis for cancer patients
4. Wayne State to develop a computer-delivered intervention for alcohol use during pregnancy
5. Computer games help people with Parkinsons disease
6. Psychopathic killers: Computerized text analysis uncovers the word patterns of a predator
7. Computer-aided design used for breast tissue reconstruction
8. UC Davis researchers develop computer model for testing heart-disease drugs
9. From the Couch to the Computer: A New Take on Therapy
10. Computer-aided detection does not improve mammogram accuracy
11. Computer-Aided Mammography Doesnt Improve Breast Cancer Detection: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Computer 'Pathologist' Could Help Assess Breast Cancer Survival
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement of ... President of North American Capital Sales at HTG Molecular . , ... the commercialization of the HTG EdgeSeq system and associated reagents in North America. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: