Navigation Links
Computer-Based Method IDs Alzheimer's Protein Structures
Date:8/22/2008

Findings hint of new treatments to prevent their formation, MIT study says

FRIDAY, Aug. 22 (HealthDay News) -- A new method of identifying protein structures related to Alzheimer's disease has been developed by researchers at the Massachusetts Institute of Technology.

The research team says its computer-based technique could help in the development of drugs that could prevent the formation of such structures.

Alzheimer's disease is characterized by two kinds of proteins (amyloid and tau) that accumulate in the brain. In a study published in the Aug. 22 issue of PLoS Computational Biology, the MIT team focused on tau.

Most proteins have similar structures, so "you can measure the lengths of individual molecules, and the average will be a pretty good description of any one," team leader Dr. Collin M. Stultz, an associate professor of biomedical engineering, explained in an MIT news release.

But tau molecules "are all over the place -- they're so diverse that it's difficult to get one measurement that describes all of the possible structures," Stultz said. This makes it a challenge to detect specific tau structures associated with Alzheimer's.

The MIT team developed a method called Energy-minima Mapping and Weighting (EMW) and "generated lots and lots of structures for both normal tau and a mutant form" associated with an increased risk for Alzheimer's disease.

Further analysis revealed that one structure was more common in the mutant form of tau and therefore likely to play a role in the development of Alzheimer's. That structure could become a target for new drug development, Stultz said.

The study looked at one mutant form of tau associated with Alzheimer's, but there are several others. Stultz said he hopes to use EMW to create "a list of all types of suspect conformations for known tau mutants. Then, from that list, we can design drugs for each."

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Aug. 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Computer-based Brain Training Addresses Many Ills
2. Stanford study highlights cost-effective method of lowering heart disease risks
3. Different method of evaluating the urinary tract system reduces radiation dose
4. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
5. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
6. Researcher developing new method for hearing loss assessment
7. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
8. GPS-like technology helps pinpoint best methods for moving injured players
9. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
10. Less invasive lymph node biopsy method could spare thousands unnecessary operations
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: