Navigation Links
Computer-Based Method IDs Alzheimer's Protein Structures
Date:8/22/2008

Findings hint of new treatments to prevent their formation, MIT study says

FRIDAY, Aug. 22 (HealthDay News) -- A new method of identifying protein structures related to Alzheimer's disease has been developed by researchers at the Massachusetts Institute of Technology.

The research team says its computer-based technique could help in the development of drugs that could prevent the formation of such structures.

Alzheimer's disease is characterized by two kinds of proteins (amyloid and tau) that accumulate in the brain. In a study published in the Aug. 22 issue of PLoS Computational Biology, the MIT team focused on tau.

Most proteins have similar structures, so "you can measure the lengths of individual molecules, and the average will be a pretty good description of any one," team leader Dr. Collin M. Stultz, an associate professor of biomedical engineering, explained in an MIT news release.

But tau molecules "are all over the place -- they're so diverse that it's difficult to get one measurement that describes all of the possible structures," Stultz said. This makes it a challenge to detect specific tau structures associated with Alzheimer's.

The MIT team developed a method called Energy-minima Mapping and Weighting (EMW) and "generated lots and lots of structures for both normal tau and a mutant form" associated with an increased risk for Alzheimer's disease.

Further analysis revealed that one structure was more common in the mutant form of tau and therefore likely to play a role in the development of Alzheimer's. That structure could become a target for new drug development, Stultz said.

The study looked at one mutant form of tau associated with Alzheimer's, but there are several others. Stultz said he hopes to use EMW to create "a list of all types of suspect conformations for known tau mutants. Then, from that list, we can design drugs for each."

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Aug. 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Computer-based Brain Training Addresses Many Ills
2. Stanford study highlights cost-effective method of lowering heart disease risks
3. Different method of evaluating the urinary tract system reduces radiation dose
4. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
5. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
6. Researcher developing new method for hearing loss assessment
7. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
8. GPS-like technology helps pinpoint best methods for moving injured players
9. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
10. Less invasive lymph node biopsy method could spare thousands unnecessary operations
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... (NYLF): Medicine will have the unique opportunity to get hands-on experience in ... high school students an immersive experience to gain invaluable, real-life medical skills that ...
(Date:12/7/2016)... ... December 07, 2016 , ... Children exposed to secondhand ... at the Icahn School of Medicine at Mount Sinai has found. The study ... young children are exposed to secondhand marijuana smoke, measurable amounts of primary metabolite ...
(Date:12/7/2016)... ... December 07, 2016 , ... OC87 Recovery Diaries (oc87recoverydiaries.com) recounts ... in a unique, personal perspective through animation. , That woman is Sheri ... at her private psychotherapy practice. Sheri’s mother, Pearl, lived with schizophrenia. , ...
(Date:12/7/2016)... , ... December 07, 2016 , ... It is vital ... is with useful, properly analyzed data. The team at Beckman Coulter has designed Kaluza, ... 'need for speed' and the need to operate in a GLP (Good Laboratory Practice) ...
(Date:12/7/2016)... ... 07, 2016 , ... Levels of a protein in the blood associated with ... online in the journal Radiology. , Heart disease and brain disease exact a major ... rapidly aging population. Damage to both organs often occurs at a subclinical stage, or ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... N.J., Dec. 8, 2016 CANTEL MEDICAL CORP. (NYSE: ... of $18,800,000, or $0.45 per diluted share, on a 22.1% ... quarter ended October 31, 2016. This compares with net income ... $153,779,000 for the first quarter ended October 31, 2015. ... quarter ended October 31, 2016 to $21,323,000, or $0.51 per ...
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire/ ... with cutting edge next-generation sequencing and bioinformatics expertise; AITbiotech Pte ... the Genome Institute of Singapore (GIS) ... joint venture between Novogene and AITbiotech – will establish a ... Singapore .   The new centre will ...
(Date:12/7/2016)... Dec. 7, 2016   IQuity, Inc., a ... Don Hardison has been appointed to ... executive with extensive experience as CEO, COO, and ... 500 companies within the molecular, clinical diagnostic, and ... and sales experience within the pharmaceutical industry. His ...
Breaking Medicine Technology: