Navigation Links
Computer-Based Method IDs Alzheimer's Protein Structures
Date:8/22/2008

Findings hint of new treatments to prevent their formation, MIT study says

FRIDAY, Aug. 22 (HealthDay News) -- A new method of identifying protein structures related to Alzheimer's disease has been developed by researchers at the Massachusetts Institute of Technology.

The research team says its computer-based technique could help in the development of drugs that could prevent the formation of such structures.

Alzheimer's disease is characterized by two kinds of proteins (amyloid and tau) that accumulate in the brain. In a study published in the Aug. 22 issue of PLoS Computational Biology, the MIT team focused on tau.

Most proteins have similar structures, so "you can measure the lengths of individual molecules, and the average will be a pretty good description of any one," team leader Dr. Collin M. Stultz, an associate professor of biomedical engineering, explained in an MIT news release.

But tau molecules "are all over the place -- they're so diverse that it's difficult to get one measurement that describes all of the possible structures," Stultz said. This makes it a challenge to detect specific tau structures associated with Alzheimer's.

The MIT team developed a method called Energy-minima Mapping and Weighting (EMW) and "generated lots and lots of structures for both normal tau and a mutant form" associated with an increased risk for Alzheimer's disease.

Further analysis revealed that one structure was more common in the mutant form of tau and therefore likely to play a role in the development of Alzheimer's. That structure could become a target for new drug development, Stultz said.

The study looked at one mutant form of tau associated with Alzheimer's, but there are several others. Stultz said he hopes to use EMW to create "a list of all types of suspect conformations for known tau mutants. Then, from that list, we can design drugs for each."

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Aug. 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Computer-based Brain Training Addresses Many Ills
2. Stanford study highlights cost-effective method of lowering heart disease risks
3. Different method of evaluating the urinary tract system reduces radiation dose
4. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
5. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
6. Researcher developing new method for hearing loss assessment
7. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
8. GPS-like technology helps pinpoint best methods for moving injured players
9. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
10. Less invasive lymph node biopsy method could spare thousands unnecessary operations
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
Breaking Medicine Technology: