Navigation Links
Computer-Aided MRI Might Help Predict Alzheimer's
Date:10/5/2010

By Madonna Behen
HealthDay Reporter

TUESDAY, Oct. 5 (HealthDay News) -- Sophisticated brain imaging techniques may help doctors one day identify which patients with mild cognitive impairment are likely to progress to Alzheimer's disease, Swiss researchers report.

Using a combination of specialized MRI scans and an artificial intelligence technique, radiologists at University Hospitals of Geneva said they were able to predict which patients had mild cognitive impairment that was likely to progress to Alzheimer's as opposed to stable mild cognitive impairment.

"Medication against Alzheimer is presumably most effective when given early in the disease progress," noted lead researcher Dr. Sven Haller, a radiologist in the department of diagnostic and interventional neuroradiology. "Our results help to identify subjects at risk for cognitive decline at an early stage, which might result in an earlier and more specific treatment."

For the study, published online Tuesday in advance of the December print issue of the journal Radiology, Haller and his colleagues examined specialized MRI scans of 35 healthy individuals, with a mean age of 64, and 69 patients with mild cognitive impairment, mean age of 65. All the patients had been diagnosed with mild cognitive impairment based on a battery of neuropsychological tests. To determine which patients had progressive versus stable mild cognitive impairment, the tests were repeated one year later.

Using a specialized technique called susceptibility-weighted MRI, Haller's group found that patients with mild cognitive impairment had a greater number of tiny leaks, or microbleeds, in the blood vessels of their brains than did control participants. The researchers found microbleeds in 33 percent of individuals with stable mild cognitive impairment and 54 percent of those with progressive mild cognitive impairment, versus only 14 percent of the control participants.

In addition, Haller's group found that those who had mild cognitive impairment were more likely to have increased concentrations of iron in certain parts of their brains and reduced levels of iron in other parts, compared with the control group.

The researchers then analyzed the MRI data with an artificial intelligence technique known as support vector machines (SVM), which helps identify patterns within a group and create classifications. With the use of SVM, Haller's group said it was able to predict with 85 percent accuracy which patients had progressive versus stable mild cognitive impairment.

However, at least one prominent Alzheimer's researcher in the United States was skeptical of the findings.

Dr. Sam Gandy is professor of neurology and psychiatry and associate director of the Alzheimer's Disease Research Center at Mount Sinai School of Medicine in New York City. He said the claim that the presence of cerebral microbleeds may be predictive of Alzheimer's "does not agree with the well-established neuropathology of mild cognitive impairment."

He added: "Perhaps these subjects are destined for vascular dementia or mixed dementia, but this study does not fit with what we know about garden-variety Alzheimer's disease."

But even though Gandy questioned these particular findings, he said he was encouraged by how much Alzheimer's research is being done right now.

"The level of attention has really been increasing substantially in the last few years, and it's very exciting to see so many people looking at so many different strategies to attack the problem," he said. "But we've still got a lot more hard work to do."

More information

For more on Alzheimer's disease, visit the U.S. National Institute on Aging.

SOURCES: Sven Haller, M.D., M.Sc., department of diagnostic and interventional neuroradiology, University Hospitals of Geneva, Switzerland; Sam Gandy, M.D., Ph.D., professor, neurology and psychiatry, associate director, Alzheimer's Disease Research Center, Mount Sinai School of Medicine, New York City; December 2010, Radiology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Computer-aided detection is increasingly being used in screening and diagnostic mammography
2. Childhood Obesity Might Be Linked to Strain of Cold Virus
3. Elderly might not benefit from TB vaccines in development
4. Early Trial Suggests COPD Drug Might Help Some Asthmatics
5. Absent Father Might Mean Earlier Puberty for Higher-Income Girls
6. Men With Low PSA at 60 Might Not Need Further Screening
7. Test Might Spot Women at High Risk for Pregnancy Complication
8. Magic Mushroom Hallucinogen Might Help Cancer Patients
9. Type 2 Diabetes Might Harm Young Brain, Study Suggests
10. Close Ties With Others Might Lengthen Life, Review Finds
11. Good Luck Charms Might Just Work
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Computer-Aided MRI Might Help Predict Alzheimer's
(Date:2/5/2016)... ... February 05, 2016 , ... ... George H. Van Allen have signed a joint enrollment and degree completion agreement. ... pathway toward associate and baccalaureate degrees at FHU|Dickson. , The agreement allows ...
(Date:2/5/2016)... ... 05, 2016 , ... US Sports Camps , official operators of Nike ... high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque New ... ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to be ...
(Date:2/5/2016)... ... , ... Regular gym users know the routine: each January, they see a ... treadmills. It’s a predictable trend. After the excesses of November and December, people make ... joining gyms, starting new walking or running routines, or signing up for Zumba. And ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, ... in KLAS: Software & Services for HIT Implementation Support & Staffing report with ... ranks vendor performance by healthcare executives, managers and clinicians representing over 4,500 hospitals ...
(Date:2/5/2016)... ... February 05, 2016 , ... Stuart Bentkover, MD, ... the PicoSure. Designed to provide the most effective tattoo removal today, Dr. Bentkover is ... results. , Developed by Cynosure, the PicoSure has been approved by the Food and ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 Amgen (NASDAQ: AMGN ... Annual Global Healthcare Conference at 9:15 a.m. ET on Wednesday, ... . David W. Meline , executive vice president and ... Live audio of the presentation can be accessed from the ... A replay of the webcast will also be available on ...
(Date:2/5/2016)... -- Patients in Alabama seeking prostate care ... longer have to travel out of state. Vituro Health ... Centers of Alabama to provide a total prostate management ... Alabama is known throughout ... cancer using many different modalities. They are the largest and ...
(Date:2/5/2016)... New York , February 5, 2016 ... new Transparency Market Research report states that the global ... in 2014 and is predicted to reach US$185.9 bn ... CAGR of 6.50% from 2014 to 2020. The title ... (Branded/Generic/Over-the-counter, Chemical/Biological, Captive/Contract Manufactured, by Geography, and by Therapeutic ...
Breaking Medicine Technology: