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Computer-Aided Detection in Screening Mammography Enhances Performance of a Single Reader
Date:2/13/2008

Large Scale, Historical Controlled Study Finds CAD Increases Sensitivity in

Cancer Detection with Only a Small Increase in Recall Rate

BEDFORD, Mass., Feb. 13 /PRNewswire-FirstCall/ -- Hologic, Inc. (Nasdaq: HOLX), a diversified medical technologies company specializing in imaging systems, diagnostics, and interventional devices dedicated to serving the healthcare needs of women, today announced the publication of a large scale breast screening trial comparing a single radiologist using computer- aided detection (CAD) to double reading without CAD. The author of the study is Dr. Matthew Gromet of the Breast Imaging Section of Charlotte Radiology, a large imaging practice (approximately 66,000 screening mammograms a year) in Charlotte, North Carolina. The study(1), published in the on-line version of the American Journal of Roentgenology, the scientific journal of the American Roentgen Ray Society, will appear in the April 2008 issue of the research journal. The study compared the recall rate, sensitivity, positive predictive value, and cancer detection rate for single reading with CAD, versus double reading without CAD. Biopsy and pathology data for positive cases were also compared.

Dr. Gromet found that a single reader with CAD had a statistically significant increase in sensitivity (11%) and a smaller increase in recall rate (4%), when compared a single reader without CAD assistance. He also found that single reading with CAD review, when compared with independent double reading, resulted in a not statistically significant increase in sensitivity but with a statistically significant lower recall rate. With manpower constraints limiting the use of double reading, Dr. Gromet concludes that "CAD appears to be an effec
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SOURCE Hologic, Inc.
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