Navigation Links
Computational analysis identifies drugs to treat drug-resistant breast cancer
Date:7/31/2012

HEIDELBERG, 31 July 2012 Researchers have used computational analysis to identify a new Achilles heel for the treatment of drug-resistant breast cancer. The results, which are published in Molecular Systems Biology, reveal that the disruption of glucose metabolism is an effective therapeutic strategy for the treatment of tumours that have acquired resistance to front-line cancer drugs such as Lapatinib.

"The growth and survival of cancer cells can often be impaired by treatment with drugs that interfere with the actions of one or more oncogenes," said Prahlad Ram, the senior author of the study and Professor at the University of Texas MD Anderson Cancer Center, Houston, Texas. "However, the clinical benefits to patients are often short lived due to acquired drug resistance. Finding alternative intervention points or so-called new addictions for cancer cells is of critical importance for designing novel therapeutic strategies against tumours. Our results reveal specific new targets for drug intervention in the metabolic pathways of cancer cells and identify existing drugs that can be used to treat drug-resistant cancer."

Lapatinib is used for the treatment of patients with advanced or metastatic breast cancer in cases where tumours overexpress the ErbB2 gene. The ErbB2 gene provides instructions for making a specific growth factor receptor. If too much of this ErbB2 growth factor receptor is made, it can lead to cells that grow and divide continuously, one of the defining characteristics of breast cancer.

The scientists used microarrays to measure gene expression in breast cancer cells with and without treatment with Lapatinib. Computational analysis of more than 15000 gene interactions revealed four major populations of genes that were regulated in a significant way. Three of these groups were the regular suspects related to drug resistance, such as genes involved in oxidation and reduction reactions or cell cycle proc
'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Lung Cancer Screening Might Pay Off, Analysis Shows
2. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
3. Analysis Finds Clinical Trials Often Small, of Poor Quality
4. Zinc Pills May Shorten Colds, Analysis Suggests
5. Biochip-based device for cell analysis
6. Analysis will examine safety of in-hospital underwater births
7. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
8. Analysis of KRYSTEXXA phase III data demonstrates improved health-related quality of life and physical function in refractory chronic gout patients
9. Meta-analysis: Interventions improve depression in cancer patients
10. Terrorism and the Olympics by-the-numbers: Analysis from UMD-based START
11. Genome analysis of brain tumors showing the way to new treatment strategies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Computational analysis identifies drugs to treat drug-resistant breast cancer
(Date:5/21/2013)... TUESDAY, May 21 (HealthDay News) -- The risk of ... when parents sleep with their infant, a new study ... risk for SIDS even if parents do not drink, ... of SIDS, which is a major cause of infant ... did not sleep with their babies. In the ...
(Date:5/21/2013)... Brussels proposes to include on tobacco packages in order ... on smokers because they only find some of them ... improve the efficacy of its anti-smoking campaigns, it should ... stronger emotional impact., These are some of the conclusions ... and Psychological Treatment at the University of Granada by ...
(Date:5/21/2013)... have long been known for their health benefits, ... therapies like anti-cancer drugs are delivered to specific ... uncovered how to create nanoparticles using natural lipids ... use them as drug delivery vehicles. UofL scientists ... their team today (May 21, 2013), published their ...
(Date:5/21/2013)... Tulsa, OK (PRWEB) May 21, 2013 Representatives ... has been such a success that the company has achieved ... re-launch plan from day one was to move Hammerhead Bicycles ... Company Spokesman and President Scott Robertson. , Robertson explained that ... and continue to exclusively focus on all things 29er ...
(Date:5/21/2013)... 2013 TheBeautyPlace.com helps brides to breathe ... a Big Day Kit including all the essentials a ... shine on their Wedding Day. , TheBeautyPlace.com features Wedding ... on their Wedding Day. Flowers blooming and warmer weather ... wedding season. From Memorial Day to October, brides to ...
Breaking Medicine News(10 mins):Health News:Bed-Sharing Raises SIDS Risk Fivefold, Study Finds 2Health News:Warning images for cigarette packs proposed by Europe do not make enough emotional impact 2Health News:UofL scientists uncover how grapefruits provide a secret weapon in medical drug delivery 2Health News:Hammerhead Bicycles Now a Standalone Brand 2Health News:TheBeautyPlace.com Previews their Emergency Big Day Kit to Get Brides Ready For this Upcoming Wedding Season 2Health News:TheBeautyPlace.com Previews their Emergency Big Day Kit to Get Brides Ready For this Upcoming Wedding Season 3
... is pondering, , TUESDAY, July 28 (HealthDay News) -- A ... raise the age at which American women should start Pap ... age at which a woman should first have a Pap ... States, however, women are told to get regular Pap smears ...
... , LAS VEGAS, July 28 American Pacific ... will release its Fiscal 2009 third quarter financial results on Tuesday, August 4, ... to participate in a teleconference to review the financial results and outlook of ... August 4, 2009 at 1:30 p.m. PDT. To access the call please dial ...
... , , DENVER, ... around the world were honored for research projects that improved ... projects were funded through Morris Animal Foundation,s (MAF) Veterinary Student ... annual meeting in June. Members of MAF,s esteemed scientific advisory ...
... , , , ... company that is expected to become public following the planned spinoff of ... 10 registration statement for the spinoff has been declared effective by the ... The effectiveness of the Form 10 was one of the few ...
... , , DETROIT, July 28 ... net sales of $48.1 million in the first quarter of Fiscal ... corresponding period of Fiscal 2009. The reduction in sales was primarily ... period, as compared to the corresponding period of Fiscal 2009. Sales ...
... , , CUPERTINO, Calif., July 28 ... Matthew Hogan, Chief Financial Officer, will be presenting at the BMO ... 5 at 4:00 pm Eastern Time. The conference is being ... A webcast of the presentation will be accessible at: ...
Cached Medicine News:Health News:Teens May Not Benefit from Pap Tests 2Health News:Teens May Not Benefit from Pap Tests 3Health News:American Pacific to Release Financial Results and Hold Fiscal 2009 Third Quarter Investor Teleconference 2Health News:Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition 2Health News:Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition 3Health News:Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition 4Health News:CareFusion Form 10 Registration Statement Declared Effective 2Health News:CareFusion Form 10 Registration Statement Declared Effective 3Health News:CareFusion Form 10 Registration Statement Declared Effective 4Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 2Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 3Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 4Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 5Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 6Health News:Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2010 7Health News:DURECT to Present at the BMO Capital Markets Healthcare Conference 2
(Date:5/21/2013)...  Janssen R&D Ireland (Janssen) today announced primary ... 3 PROMISE study demonstrating that use of the ... virologic response 12 weeks after the end of ... 1 chronic hepatitis C adult patients with compensated ... when administered once daily with pegylated interferon and ...
(Date:5/21/2013)... 2013 Abaxis, Inc. (NasdaqGS: ABAX), a medical ... that Martin Mulroy , chief commercial ... & Veterinary Conference on Wednesday, May 29, 2013 at ... Le Parker Meridien Hotel in New York ... Abaxis develops, manufactures, markets and sells portable blood analysis ...
(Date:5/21/2013)... 2013  BioRestorative Therapies, Inc. ("BRT" or the "Company") ... developing stem cell based therapies for various personal applications, ... President and CEO, will be presenting at the Marcum ... held on Thursday, May 30, 2013 at the Grand ... New York City.  Mr. Weinreb,s presentation will take place ...
Breaking Medicine Technology:Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients 2Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients 3Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients 4Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients 5Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients 6Primary Efficacy and Safety Findings from Phase 3 Study of Janssen's Simeprevir Administered Once Daily Demonstrate Sustained Virologic Response in Treatment-Experienced Genotype 1 Chronic Hepatitis C Adult Patients 7Abaxis, Inc. to Present at the Stifel Annual Dental & Veterinary Conference 2BioRestorative Therapies, Inc. to Present at the Marcum MicroCap Conference 2BioRestorative Therapies, Inc. to Present at the Marcum MicroCap Conference 3
... one of New Zealand,s leading hospitals have delivered more ... in the first month of its implementation. The TrueBeam ... ) adds to Wellington Hospital,s radiotherapy capabilities and enables ... first patient in the country – and the southern ...
Belgium, United Kingdom, Austria and The Netherlands. The DORC companies employ about 300 people. Visit our website : http://www.dorc.nl  ...
Cached Medicine Technology:Wellington Hospital, New Zealand Becomes First in Southern Hemisphere to Offer Patients Fast and Precise TrueBeam Treatments 2Wellington Hospital, New Zealand Becomes First in Southern Hemisphere to Offer Patients Fast and Precise TrueBeam Treatments 3
Size: Medium. 22.50 mm by 24.00 mm. Clear lucite. Supplied sterile....
... 6.4 x 80 mm. Storz offers ... designed by Harvey A. Lincoff, M.D. ... cell sponge which is non-toxic and ... edges to minimize scleral intrusion. These ...
... x 80 mm. Storz offers the ... by Harvey A. Lincoff, M.D. The ... which is non-toxic and non-antigenic. Implants ... minimize scleral intrusion. These implants are ...
... Size: 5.0 x 2.5 x 80 mm. Half ... by Harvey A. Lincoff, M.D. has been modified ... design. The material is a closed cell sponge ... with rounded edges to minimize scleral intrusion. These ...
Medicine Products: