Navigation Links
Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease
Date:7/27/2009

St. Jude scientists identify new genes implicated in childhood acute myeloid leukemia (AML), but analysis underscores the need for more detailed look at the complete AML genome

MEMPHIS, Tenn., July 27 /PRNewswire-USNewswire/ -- The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children's Research Hospital. The research appears in the July 27 online edition of the Proceedings of the National Academy of Sciences.

"Our data raise the possibility that the development of AML may require fewer genetic alterations than other cancers and that a very limited number of biological processes may need to be altered in hematopoietic stem cells, multi-potential progenitors or committed myeloid progenitors to convert them from a normal cell to AML," the authors noted, referring to several types of immature and maturing cells that give rise to this cancer. James Downing, M.D., St. Jude scientific director and the paper's senior author, said the findings highlight questions about what it takes to transform a normal cell into a cancer cell. "The complement of genetic lesions varies across the different genetic subtypes of AML, but there are very few lesions in total. That is surprising. Most cancers have lots of alterations," he explained.

AML accounts for about 20 percent of childhood leukemia. This year it will be diagnosed in about 500 U.S. children. About 60 percent of young AML patients become long-term survivors.

This study reflects the push to chart the genetic changes that free cells from normal controls and allow the uncontrolled cell division that is a hallmark of cancer. Downing said the findings underscore the need to survey the entir
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Los Angeles County Launches Its Most Comprehensive Campaign Ever to Encourage HIV Testing
2. Comprehensive VMAT Solution From Elekta on Center Stage at 2009 AAPM Annual Meeting
3. EngagementHealth(R) Launches Comprehensive Wellness Program with Store Kraft - 80% of Employees and Spouses Participate in Programs
4. Global Health Council Welcomes President Obamas Call in Ghana for Comprehensive Global Health Strategy
5. A comprehensive review of addiction to prescription painkillers among patients and physicians
6. NCI Renews Mayo Clinic Cancer Center Support Grant, Extends Comprehensive Status
7. NCI renews Mayo Clinic Cancer Center support grant, extends comprehensive status
8. Lenox Hill Heart and Vascular Institute of New York and Mentice, Inc. Announce the Successful Completion of Their 1st Trans-septal Cardiac Catheterization Training Course: A Comprehensive Hands-On Tutorial with Certification on June 12th and 13th 2009 in
9. Patient Advocates From All 50 States Gather in Nations Capitol to Meet With Lawmakers and Urge Passage of Comprehensive Health Care Reform
10. Former Senate Majority Leaders Baker, Daschle and Dole Release Bipartisan Framework for Comprehensive Health Reform
11. Siemens Makes Innovation Accessible with Comprehensive Molecular Imaging Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Cardiac Arrest Association, offers heart healthy Valentine,s Day gift ideas ... by the celebration of Valentine,s Day and a great time ... will splurge on jewelry, flowers and other luxuries, why not ... and healthy at heart? "Every two minutes, someone in the ...
... among 1,189 Initiates from around the world who became Fellows of the ... annual Clinical Congress in San Francisco. , ... Chicago (PRWEB) February 3, ... from around the world who became Fellows of the American College of ...
... Ethicon Endo-Surgery (a Johnson & Johnson company), the ... among the first bariatric surgeons in the U.S. ... generation of its distinctive surgical weight loss method: ... is gaining a reputation as being one of ...
... 3 Press Ganey Associates, Inc. and the Harvard ... formally announced continued collaboration through 2009. The two organizations, ... and innovation, are combining their expertise and reach to ... how to adapt to the changing face of health ...
... Michigan Orthopedic ServicesDETROIT, Feb. 2 Huron Capital Partners ... ("MOS") has acquired O&P Professional Care as part of ... The business will be managed under the MOS ... MOS operates a network of 11 patient care ...
... For many cancer patients, chemotherapy can be worse than cancer ... not another -- or the tumor may mutate and stop ... time, ineffective treatment and toxic side effects. , ... one day allow doctors to evaluate a tumor,s response to ...
Cached Medicine News:Health News:The Sudden Cardiac Arrest Association Shoots Straight for the Heart 2Health News:The Sudden Cardiac Arrest Association Shoots Straight for the Heart 3Health News:Dallas Surgeon Among 1,189 Initiated Into American College of Surgeons 2Health News:Dallas – Fort Worth Bariatric Surgeon Dr. David Kim One of Few in America Selected to Perform New Weight Loss Surgery Procedure 2Health News:Dallas – Fort Worth Bariatric Surgeon Dr. David Kim One of Few in America Selected to Perform New Weight Loss Surgery Procedure 3Health News:Dallas – Fort Worth Bariatric Surgeon Dr. David Kim One of Few in America Selected to Perform New Weight Loss Surgery Procedure 4Health News:Press Ganey and Harvard's Forces of Change Announce 2nd Annual Collaboration 2Health News:Press Ganey and Harvard's Forces of Change Announce 2nd Annual Collaboration 3Health News:Huron Capital Continues Acquisition Activity 2Health News:UCLA scientists develop crystal ball for personalized cancer treatment 2
(Date:12/15/2014)... , December 15, 2014 Heptares ... company, is pleased to announce the grant of multiple ... relating to its GPCR-focused drug discovery platform. The ... the global patent estate covering Heptares, technologies and products ... of patents recently granted by the US Patent Office ...
(Date:12/13/2014)... 2014  Radiologists can transmit their reports, which ... referring physicians, electronic health records (EHR) systems securely, ... That was the message behind ... at the recent Radiology Society of North America ... reports in this manner also helps referring physicians ...
(Date:12/13/2014)... PLAINSBORO, N.J. and INDIANAPOLIS , ... diabetes care, and Chip Ganassi Racing Teams (CGRT), today announced ... Nordisk as the primary sponsor of the No. 83 Novo ... in the Verizon IndyCar Series. Kimball, ... first and only licensed driver with diabetes in the history ...
Breaking Medicine Technology:Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... SILVER SPRING, Md., Nov. 15, 2011 Nov. ... joint effort by the Food and Drug Administration ... and other health care professional, government, academic, international ... of antibiotics.  (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) ...
... Medical Simulation Corporation (MSC) is proud to offer innovative, ... funding through the Health Care Innovation Challenge, announced on ... Human Services. Simulation provides a unique, risk-free ... skills in managing patients with diagnoses associated with high ...
Cached Medicine Technology:FDA Consumer Health Information - Video: Get Smart About Antibiotics 2Medical Simulation Corporation Offers Innovative Training Solutions for Healthcare Organizations Applying to the Department of Health and Human Services' Health Care Innovation Challenge 2
... Disc is a Hand Assisted Laparoscopic Surgery ... the surgeons hand may facilitate the procedure, ... has applications in colorectal, urological and general ... extracorporeal extension of pneumoperitoneum and abdominal access ...
... SleepStyle 200 series offers a range ... models. The design delivers therapy to ... features promote results in commercial and ... strongest differentiator in the SleepStyle 200 ...
... 200 series offers a range of ... The design delivers therapy to meet ... promote results in commercial and clinical ... differentiator in the SleepStyle 200 series ...
... S6 Lightweight II CPAP has sound ... that maintains consistent pressure. The backlit ... the settings easy, and the interface ... adjustments is simple. This CPAP device ...
Medicine Products: