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Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
Date:9/6/2010

OA concentrations were higher than those detected in a nationally representative survey (29.3 nanograms per milliliter vs. 3.9 nanograms per milliliter), but PFOS concentrations were similar (19.1 nanograms per milliliter vs. 19.3 nanograms per milliliter).

After adjusting for related variables, higher PFOA levels were associated with increased total cholesterol and LDL or "bad" cholesterol, and PFOS was associated with increased total cholesterol, LDL cholesterol and HDL or "good" cholesterol. There was no association between either compound and triglyceride levels.

On average, the one-fifth of children and teens with the highest PFOA levels had total cholesterol levels 4.6 milligrams per deciliter higher and LDL cholesterol levels 3.8 milligrams per deciliter higher than the one-fifth with the lowest PFOA levels. In addition, there was an average difference of 8.5 milligrams per deciliter in total cholesterol levels and 5.8 milligrams per deciliter in LDL cholesterol levels between the one-fifth of participants with the highest and lowest PFOS levels.

"The non-linear nature of the observed associations, particularly for PFOA, suggests a possible saturation point in an underlying physiologic mechanism," the authors write. "PFOA and PFOS specifically, and possibly perfluoroalkyl acids as a general class, appear to be associated with serum lipids, and the association seems to exist at levels of PFOA and PFOS exposure that are in the range characterized by nationally representative studies."

Although the design of the study limits cause-and-effect interpretations, the results suggest the association between PFOA and PFOS and elevated cholesterol levels warrant further study, the authors note. "Should the association prove to be etiologic, the cumulative effects of such an elevation in cholesterol on long-term cardiovascular health are unclear given the early age at which these associations were observed."


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Contact: Kim Fetty
fettyki@wvuh.com
304-293-7087
JAMA and Archives Journals
Source:Eurekalert

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