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Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
Date:9/6/2010

Children and teens with higher blood levels of chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

Humans are exposed to the man-made compounds known as perfluoroalkyl acidsincluding perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS)through drinking water, dust, food packaging, breast milk, cord blood, microwave popcorn, air and occupational exposure, according to background information in the article. Recent national survey results reported detection of PFOA and PFOS in almost all samples of human serum. Perfluoroalkyl acids are used during the manufacture of fluoropolymers, which give non-stick heat resistance to cookware and breathable, waterproof properties to fabrics and upholstery. PFOA and PFOS may also result from the breakdown of compounds used as coating for commercial food packaging, factory treatments for fabrics and carpets and manufacturer pretreatment for stain-resistant clothing.

Animal studies have identified the liver as the primary organ affected by perfluoroalkyl acid exposure, with potential effects in human including alterations in cholesterol levels. Stephanie J. Frisbee, M.Sc., M.A., of West Virginia University School of Medicine, Morgantown, and colleagues assessed serum lipid levels in 12,476 children and adolescents (average age 11.1) included in the C8 Health Project, which resulted from the settlement of a class-action lawsuit regarding PFOA contamination of the drinking water supply in the midOhio River Valley.

After enrolling in 2005 or 2006, the children and teens submitted blood samples; their average PFOA concentration was 69.2 nanograms per milliliter and average PFOS concentration was 22.7 nanograms per milliliter. Among 12- to 19-year old participants, PF
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Contact: Kim Fetty
fettyki@wvuh.com
304-293-7087
JAMA and Archives Journals
Source:Eurekalert

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