Navigation Links
Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
Date:9/6/2010

Children and teens with higher blood levels of chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

Humans are exposed to the man-made compounds known as perfluoroalkyl acidsincluding perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS)through drinking water, dust, food packaging, breast milk, cord blood, microwave popcorn, air and occupational exposure, according to background information in the article. Recent national survey results reported detection of PFOA and PFOS in almost all samples of human serum. Perfluoroalkyl acids are used during the manufacture of fluoropolymers, which give non-stick heat resistance to cookware and breathable, waterproof properties to fabrics and upholstery. PFOA and PFOS may also result from the breakdown of compounds used as coating for commercial food packaging, factory treatments for fabrics and carpets and manufacturer pretreatment for stain-resistant clothing.

Animal studies have identified the liver as the primary organ affected by perfluoroalkyl acid exposure, with potential effects in human including alterations in cholesterol levels. Stephanie J. Frisbee, M.Sc., M.A., of West Virginia University School of Medicine, Morgantown, and colleagues assessed serum lipid levels in 12,476 children and adolescents (average age 11.1) included in the C8 Health Project, which resulted from the settlement of a class-action lawsuit regarding PFOA contamination of the drinking water supply in the midOhio River Valley.

After enrolling in 2005 or 2006, the children and teens submitted blood samples; their average PFOA concentration was 69.2 nanograms per milliliter and average PFOS concentration was 22.7 nanograms per milliliter. Among 12- to 19-year old participants, PFOA concentrations were higher than those detected in a nationally representative survey (29.3 nanograms per milliliter vs. 3.9 nanograms per milliliter), but PFOS concentrations were similar (19.1 nanograms per milliliter vs. 19.3 nanograms per milliliter).

After adjusting for related variables, higher PFOA levels were associated with increased total cholesterol and LDL or "bad" cholesterol, and PFOS was associated with increased total cholesterol, LDL cholesterol and HDL or "good" cholesterol. There was no association between either compound and triglyceride levels.

On average, the one-fifth of children and teens with the highest PFOA levels had total cholesterol levels 4.6 milligrams per deciliter higher and LDL cholesterol levels 3.8 milligrams per deciliter higher than the one-fifth with the lowest PFOA levels. In addition, there was an average difference of 8.5 milligrams per deciliter in total cholesterol levels and 5.8 milligrams per deciliter in LDL cholesterol levels between the one-fifth of participants with the highest and lowest PFOS levels.

"The non-linear nature of the observed associations, particularly for PFOA, suggests a possible saturation point in an underlying physiologic mechanism," the authors write. "PFOA and PFOS specifically, and possibly perfluoroalkyl acids as a general class, appear to be associated with serum lipids, and the association seems to exist at levels of PFOA and PFOS exposure that are in the range characterized by nationally representative studies."

Although the design of the study limits cause-and-effect interpretations, the results suggest the association between PFOA and PFOS and elevated cholesterol levels warrant further study, the authors note. "Should the association prove to be etiologic, the cumulative effects of such an elevation in cholesterol on long-term cardiovascular health are unclear given the early age at which these associations were observed."


'/>"/>

Contact: Kim Fetty
fettyki@wvuh.com
304-293-7087
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
2. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
3. Concentration, timing and interactions are key when it comes to dietary compounds
4. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
5. Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens
6. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
7. Certain pain medications do not appear to be associated with skin cancer risk
8. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
9. New research shows emotional impact of low sexual desire and associated distress
10. Increased HAART coverage associated with 50 percent drop
11. Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, Inc., ... development and manufacturing of collagen and mineral based ... today that Bill Messer has joined ... to further leverage the growing portfolio of oral ... Bill joins the Collagen Matrix executive ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
Breaking Medicine Technology: