Navigation Links
Compounds in mate tea induce death in colon cancer cells
Date:1/23/2012

URBANA Could preventing colon cancer be as simple as developing a taste for yerba mate tea? In a recent University of Illinois study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of this brew, which has long been consumed in South America for its medicinal properties.

"The caffeine derivatives in mate tea not only induced death in human colon cancer cells, they also reduced important markers of inflammation," said Elvira de Mejia, a U of I associate professor of food chemistry and food toxicology.

That's important because inflammation can trigger the steps of cancer progression, she said.

In the in vitro study, de Mejia and former graduate student Sirima Puangpraphant isolated, purified, and then treated human colon cancer cells with caffeoylquinic acid (CQA) derivatives from mate tea. As the scientists increased the CQA concentration, cancer cells died as a result of apoptosis.

"Put simply, the cancer cell self-destructs because its DNA has been damaged," she said.

The ability to induce apoptosis, or cell death, is a promising tactic for therapeutic interventions in all types of cancer, she said.

de Mejia said they were able to identify the mechanism that led to cell death. Certain CQA derivatives dramatically decreased several markers of inflammation, including NF-kappa-B, which regulates many genes that affect the process through the production of important enzymes. Ultimately cancer cells died with the induction of two specific enzymes, caspase-3 and caspase-8, de Mejia said.

"If we can reduce the activity of NF-kappa-B, the important marker that links inflammation and cancer, we'll be better able to control the transformation of normal cells to cancer cells," she added.

The results of the study strongly suggest that the caffeine derivatives in mate tea have potential as anti-cancer agents
'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
2. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
3. Concentration, timing and interactions are key when it comes to dietary compounds
4. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
5. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
6. New compounds may treat both alcohol and cigarette addictions
7. Bioactive compounds in berries can reduce high blood pressure
8. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
9. Good news for meat lovers: Most ready-to-eat meat products contain very few cancerous compounds
10. High levels of toxic compounds found on coasts of West Africa
11. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 Two Moms in ... three new products including: a Cacao Nib Nut Bar, Green ... Moms in the Raw products, each is 100% organic, gluten-free, ... is picky, so I’m constantly working on creating the best-tasting, ... healthy and tasty choices,” said Shari Leidich, Founder and VP ...
(Date:7/31/2014)... Shiitakes have been called “The workhorse of the ... Sauce below, they cook up in 5-10 minutes. They ... deep flavor -- four to ten times that of ... they're cooked with, so they add variety. They have ... are rich in fiber and contain a fat-absorbing compound ...
(Date:7/31/2014)... advocated in the United States, a new study suggests ... favorably, people share implicit hierarchies for racial, religious, and ... explicit attitudes and values. , The study findings appear ... Association for Psychological Science. , "People from relatively low-status ... have the most power. At the same time, ...
(Date:7/31/2014)... New Delhi, India (PRWEB) July 31, 2014 ... company, has launched a new service named ‘Remove Bad ... against which bad reviews are published on various review ... study about the world of internet marketing, the sites ... by its competitors in order to tailor the service. ...
(Date:7/31/2014)... The Beryl Institute announces three new members ... four new members of its Patient Experience Advisory ... community of practice and premier thought leader on improving ... members are industry leaders who advise on strategy, growth ... market and industry trends. The advisory board provides input ...
Breaking Medicine News(10 mins):Health News:Two Moms in the Raw Launches Three New, Raw, Sprouted 100% Organic Snacks 2Health News:Two Moms in the Raw Launches Three New, Raw, Sprouted 100% Organic Snacks 3Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 2Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 3Health News:Research reveals pervasive implicit hierarchies for race, religion, and age 2Health News:Reputation Management India Launches a New Service Called ‘Remove Bad Reviews’ 2Health News:The Beryl Institute Announces Seven New Patient Experience Board Members 2Health News:The Beryl Institute Announces Seven New Patient Experience Board Members 3
... first-ever genetic link to the reason African-Americans are at increased ... researchers at the University of Alabama at Birmingham (UAB) is ... testing. In the study, African-Americans with a Pro72 protein variant ... advanced form of colon cancer compared to whites, the researchers ...
... The Kroger Co. said today it is recalling Kroger Lite ... SEP-25-09 sold in Kroger stores in Southwestern Ohio, including Cincinnati and ... may be contaminated with Salmonella. No illnesses have been reported in ... , , , ...
... 31 LifeCare Holdings, Inc. (the "Company") today announced its ... 31, 2008. Three Months Ended December 31, ... patient service revenue of $94.2 million for the three months ... to the same period in 2007 while patient days were ...
... With the economy in a decline, many healthcare facilities are providing ... , ... (Vocus) March 31, 2009 -- Faced with ... money by relying on dependable professionally refurbished medical equipment ...
... Tenn., March 31 ProAssurance Corporation (NYSE: ... Podiatry Insurance Company of America (PICA) have overwhelmingly approved the ... into ProAssurance as a standalone subsidiary. ... domiciliary state of Illinois , is ...
... BSX ) announced today that the Court of ... Company,s stent litigation with Johnson and Johnson (J&J). The ... Bx Velocity and Cypher Stent Systems infringe Boston Scientific,s patent ... reversed the District Court with respect to the TAXUS Liberte ...
Cached Medicine News:Health News:LifeCare Holdings, Inc. Announces Year-End Results 2Health News:LifeCare Holdings, Inc. Announces Year-End Results 3Health News:LifeCare Holdings, Inc. Announces Year-End Results 4Health News:LifeCare Holdings, Inc. Announces Year-End Results 5Health News:LifeCare Holdings, Inc. Announces Year-End Results 6Health News:LifeCare Holdings, Inc. Announces Year-End Results 7Health News:LifeCare Holdings, Inc. Announces Year-End Results 8Health News:LifeCare Holdings, Inc. Announces Year-End Results 9Health News:LifeCare Holdings, Inc. Announces Year-End Results 10Health News:LifeCare Holdings, Inc. Announces Year-End Results 11Health News:LifeCare Holdings, Inc. Announces Year-End Results 12Health News:LifeCare Holdings, Inc. Announces Year-End Results 13Health News:LifeCare Holdings, Inc. Announces Year-End Results 14Health News:LifeCare Holdings, Inc. Announces Year-End Results 15Health News:Healthcare Facilities Focusing on Affordability, Dependability 2Health News:Healthcare Facilities Focusing on Affordability, Dependability 3Health News:PICA Policyholders Approve ProAssurance Transaction 2Health News:PICA Policyholders Approve ProAssurance Transaction 3Health News:PICA Policyholders Approve ProAssurance Transaction 4Health News:PICA Policyholders Approve ProAssurance Transaction 5Health News:PICA Policyholders Approve ProAssurance Transaction 6Health News:Appeals Court Affirms That J&J Stents Infringe Boston Scientific Patent; Claims Against TAXUS Liberte Dismissed 2Health News:Appeals Court Affirms That J&J Stents Infringe Boston Scientific Patent; Claims Against TAXUS Liberte Dismissed 3
(Date:7/31/2014)... -- Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) ... on Thursday, August 7, 2014 before markets open. The ... conference call at 8:00 a.m. Eastern time (5:00 a.m. ... call and webcast to discuss financial results and recent ... calling (800) 708-4540 (domestic) or (847) 619-6397 (international), participant ...
(Date:7/31/2014)... India , July 31, 2014 ... Inc. announced today that they recently entered into ... European Union and certain other European countries, for ... post-surgical pain management. Cipla intends to launch the ... its own label into the German market late ...
(Date:7/31/2014)... and NOTTINGHAM, England ... Inc. (NASDAQ: CBRX ) today announced ... Ltd., have announced a collaboration that will support ... and formulation development stage.  Molecular Profiles, pharmaceutical development ... preclinical drug metabolism and pharmacokinetics (DMPK) to give ...
Breaking Medicine Technology:Orexigen Therapeutics to Host Second Quarter 2014 Financial Results Conference Call and Webcast 2Cipla and BioQuiddity Announce EU Commercial Partnership for OneDose-ReadyfusOR for Post-Surgical Pain Management 2Cipla and BioQuiddity Announce EU Commercial Partnership for OneDose-ReadyfusOR for Post-Surgical Pain Management 3Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 2Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 3
... Awarepoint Corporation , the leading provider ... health care, and MEDITECH , a leading ... announced a collaboration to integrate technologies to provide ... critical milestone tracking within MEDITECH,s enterprise-wide electronic health ...
... Company (Nasdaq: PRGO ; TASE) today announced that ... 2012 on Thursday, October 27, 2011 at approximately 8:00 a.m. ... a.m. (ET) hosted by Joseph C. Papa, Perrigo,s Chairman and ... available live via webcast to interested parties on the Perrigo ...
Cached Medicine Technology:Awarepoint Corporation and MEDITECH Collaborate to Integrate Technology Platforms 2Awarepoint Corporation and MEDITECH Collaborate to Integrate Technology Platforms 3
... System is a long term, quality solution ... in both posterior stabilized and anatomically correct ... provides the flexibility needed to address patients' ... of identification keeps the user in mind ...
... Virtual Fluoroscopy software from ... has incorporated ease of ... features such as multiplanar ... models of image guided ...
... GE's surgical navigation ... first system to integrate ... tracking technology. It features ... fluoroscopic image to the ...
The ZEPHIR Anterior Cervical Plate System is the lowest profile plate clinically available....
Medicine Products: