Navigation Links
Compounds activate key cancer enzyme to interfere with tumor formation
Date:8/27/2012

Scientists have known for decades that cancer cells use more glucose than healthy cells, feeding the growth of some types of tumors. Now, a team that includes researchers from the National Institutes of Health's new National Center for Advancing Translational Sciences (NCATS) has identified compounds that delay the formation of tumors in mice, by targeting a key enzyme that governs how cancer cells use glucose and its metabolites.

The study, published August 26 in the advance online publication of Nature Chemical Biology, was led by researchers from the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT), Cambridge. Researchers from the Structural Genomics Consortium at the University of Toronto and Harvard Medical School, Boston, also joined NCATS scientists to author the paper.

All cells use an enzyme called pyruvate kinase to derive energy from glucose. Recent studies have shown that cancer cells preferentially use one form of pyruvate kinase, called PKM2, which uses glucose to make additional cancer cells instead of energy. This altered metabolic state appears to be a fundamental aspect of many cancers, and reversing the process represents a new opportunity for cancer treatment.

In the study report, the researchers describe the identification of molecular compounds that activate PKM2, correct the way human cancer cells use glucose, and delay tumor development and decrease tumor size in mice. The results support PKM2 activation as a potential therapeutic strategy for cancer. However, the researchers emphasized there is much more work needed to understand the implications of their findings for humans, such as determining what types of tumors might be sensitive to PKM2 activation.

"The last several years have brought an avalanche of new discoveries that have begun to explain a phenomenon of altered cancer cell metabolism first described almost 90 years ago," said Chr
'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-435-0888

Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Natural Sciences Repository Publishes Chromatography and Acidic Compounds Resources
2. Metabolic protein wields phosphate group to activate cancer-promoting genes
3. Glucose deprivation activates feedback loop that kills cancer cells, UCLA study shows
4. Skp2 activates cancer-promoting, glucose-processing Akt
5. Strategy discovered to activate genes that suppress tumors and inhibit cancer
6. Lack of sleep found to be a new risk factor for aggressive breast cancers
7. Cancer vaccine Special Focus series published in Human Vaccines & Immunotherapeutics
8. Obese and overweight women face increased risk of recurrence of most common type of breast cancer
9. Radiation for Childhood Cancer Might Raise Diabetes Risk
10. Missing Follow-Up Colonoscopies Could Raise Colon Cancer Risk
11. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Thompson HealthDay Reporter THURSDAY, ... Thursday an additional $100 million in the fight against the ... which brings the World Bank,s total pledge to more than ... care workers to the three hardest-hit countries -- Guinea, Liberia ... Ebola crisis has increased significantly in recent weeks, but we ...
(Date:10/31/2014)... by the National Institutes of Health will facilitate ... reframe mental health research, from diagnosis to treatment. ... established by the National Institute of Mental Health ... of the institute,s RDoC initiative. , The ... the pace of research that translates basic science ...
(Date:10/31/2014)... HealthDay Reporter THURSDAY, Oct. 30, ... organ transplantation is nothing new. The first kidney transplant ... in 1963 and the first human heart transplant in 1967. ... patient,s entire face. One major organ still eludes the ... team of U.S. scientists has its way, that dream may ...
(Date:10/31/2014)... News) -- The number of medical malpractice payments in ... to a new study. And compensation payment amounts ... or declined in recent years, researchers report online Oct. ... Association . "For many physicians, the prospect of ... of modern clinical practice," researchers, led by Michelle Mello, ...
(Date:10/31/2014)... WASHINGTON, DC (October 31, 2014) — A new ... (Milken Institute SPH) at the George Washington University ... for pregnant women who are enrolled in Covered ... which includes the Comprehensive Perinatal Services Program (CPSP). ... the nation,s most successful programs ever developed for ...
Breaking Medicine News(10 mins):Health News:World Bank Pledges $100M More to Fight West Africa's Ebola Outbreak 2Health News:NIMH creates new unit to support its research domain criteria initiative 2Health News:Scientists Set Their Sights on First Whole-Eye Transplant 2Health News:Scientists Set Their Sights on First Whole-Eye Transplant 3Health News:Fewer Malpractice Claims Paid in U.S. 2Health News:Report examines health care challenges for pregnant women enrolled in covered California 2
... cancer of the eye need not have to remove their ... The results of the Collaborative ocular Melanoma ... found that survival rates were the same regardless of whether ... radiation therapy.// , Davidorf, Professor ...
... affects women in their 30s and 40s, especially women.The illness ... cause pain, inflammation and joint destruction. , ... condition, but one third of the patients discontinue treatment early ... taking Methotrexate are prone for their drug-related liver damage .This ...
... exercise can improve their health or it would not make a ... Consensus statements published by the American College of ... researchers often can't tell how much health-improvement pay-off will result from ... make a difference at all. , , ...
... levels is becoming an increasingly important part of a medical ... or 'good' cholesterol) levels should be high, and low density ... At Johns Hopkins ... to measure non-HDL cholesterol too. This is the difference between ...
... to kill the deadly Hepatitis E virus has been designed by ... would kill the virus by cutting RNA. , , ... animals. The cloned virus could also be used for diagnostic purposes ... For this, the team had produced ...
... in tomato products, such as tomato sauce and ketchup, have ... especially prostate cancer, but the reason for such an action ... that lycopene, which is found in tomato products and other ... and treating the disease in its earliest stages.// ...
Cached Medicine News:Health News:How much can exercise improve health? 2Health News:Protective effects of tomatoes in prostate cancer 2
(Date:10/30/2014)... Oct. 30, 2014  Electronic health records uptake ... result of government initiatives and the considerable resources ... have invested over the past five years. Electronic ... IT, and U.S. clinicians use them on a ... http://photos.prnewswire.com/prnh/20141029/155278LOGO Frost & Sullivan,s ...
(Date:10/30/2014)... WOONSOCKET, R.I. , Oct. 30, 2014 CVS ... entered into new clinical affiliations with three leading regional health ... for patients. The collaborating health systems include Baptist Health System ... affiliated hospitals which include Commonwealth Health in Pennsylvania ... Arizona , and Tennova Healthcare in ...
(Date:10/30/2014)... China Biologic Products, Inc. (NASDAQ: CBPO, "China Biologic" or ... in China , today announced that ... results on Wednesday, November 5, 2014 after the market ... a conference call at 7:30 a.m. Eastern Time on ... Time on November 6, 2014, to discuss third quarter ...
Breaking Medicine Technology:Electronic Health Record Usability: CIOs Weigh In 2Electronic Health Record Usability: CIOs Weigh In 3Electronic Health Record Usability: CIOs Weigh In 4CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4China Biologic to Report Third Quarter 2014 Financial Results 2
... of a new cytokine called IL-35 could allow clinicians ... response, MEMPHIS, Tenn., Nov. 21 Investigators at ... molecule,that prevents immune responses from running amok and damaging ... new treatments for cancer, using,vaccines; for autoimmune diseases, such ...
... Nov. 20 A new study,released by Indiana ... in immediate and significant improvements in heart,health, particularly ... decrease in,hospital admissions for heart attacks, also known ... prior cardiac history in Monroe,County, Indiana versus the ...
Cached Medicine Technology:St. Jude Finds Molecule That Could Improve Cancer Vaccine and Therapy for Other Diseases 2Smokefree Workplace Law Reduces Heart Attacks 59% Among Nonsmokers, New Research Shows 2
A flexible hematology platform:, 32 parameters, Automatic result validation, Cytology atlas included, CBC and 5+3 DIFF...
... L.E.D. is mounted coaxially on the loupe ... battery pack giving 4 hours continuous use. ... and a charging unit that can hold ... as being a convenient container to keep ...
The PDM utilizes the latest technology for measuring interpupillary distance and left/right pupil-to-nose distance. Lightweight and easy-to-use, the PDM provides accurate and repeatable PD measuremen...
Inquire...
Medicine Products: