Navigation Links
Compounds Found to Protect Rabbits From Cerebral Palsy
Date:2/25/2009

Discovery called exciting, but human application remains elusive, expert says

WEDNESDAY, Feb. 25 (HealthDay News) -- In experiments with rabbits, a team of scientists has created two chemical compounds that appear to protect a fetus from developing cerebral palsy from a lack of oxygen.

"It is known that if you have too much nitric oxide in the brain, which can be produced during hypoxia, it leads to fetal neurodegeneration," said lead researcher Richard B. Silverman, a chemistry professor at Northwestern University.

If such an event occurs during pregnancy, it can lead to brain damage in the fetus that can result in cerebral palsy, Silverman said. "This can happen right at the end of pregnancy," he explained.

Common causes of hypoxia include a pinched umbilical cord or a cord wrapped around the fetus's neck or shoulder.

The report was published online Wednesday in the Annals of Neurology.

Silverman's team developed two compounds that block an enzyme in brain cells that produces nitric oxide. At normal levels, nitric oxide is a neurotransmitter, which is important for brain functioning, but at high levels it can damage brain tissue. An excess of nitric oxide in the brain is believed to play a role in cerebral palsy.

In experiments with rabbits, excess nitric oxide caused most of the fetuses to die, and those that survived were severely brain-damaged, Silverman said.

"If you administer the compounds that we made a half-hour prior to the hypoxic insult, you can protect the fetus from neurodegeneration," Silverman said. All the animals treated with the compounds lived, and those given placebo died. Among animals given just one of the compounds, up to 80 percent were born normal, Silverman said.

Silverman said that he thinks the compounds can be used to treat infants with compromised oxygen levels before cesarean delivery. "The sooner you can protect the fetal br
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Compounds that trigger beta cell replication identified by JDRF funded researchers
2. Stunning finding: Compounds protect against cerebral palsy
3. AstraZeneca Licenses Novel Antidepressant Compounds Discovered by Mayo Clinic and Virginia Tech Collaboration
4. New platinum-phosphate compounds kill ovarian cancer cells
5. Scientists exploring new compounds to target muscular dystrophy
6. University of Illinois - Chicago Study: Raisins Contain Compounds that May Inhibit Cavity-causing Bacteria
7. InNexus Biotechnology Announces Third Antibody and Expands Pipeline of Anticancer Compounds
8. USPTO Issues Patent Embodying Methodologies for Abating a Broad Range of Allergens, Pathogens, Viruses, Bacteria, Odors and Volatile Organic Compounds.
9. Study Finds Spice-Rich Marinades Can Reduce Harmful Compounds When Grilling
10. ChromaDex Licenses Green Chemistry Technology to Manufacture a New Class of Super Fruit Compounds
11. Drugs With Marijuana Compounds Dont Boost Adverse Events
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 This is ... of the global Sterilizers industry with a focus on ... the market status of the Sterilizers manufacturers and is ... and individuals interested in the industry. This report provides ... applications and manufacturing technology. In this part, the report ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 The report ... 2023” focuses on the current treatment landscape, unmet needs, ... market. TS-1 is an anti-cancer drug which is typically ... and is also used for treating gastric cancer and ... otastat potassium. The drug was first approved in 1999 ...
(Date:12/25/2014)... the popular online supplier of wedding dresses and special occasion ... black one-shoulder cocktail dresses . In addition, all these elegant ... prices, up to 70% off. , The development ... You know, we have thousands of frequent callers in the ... can visit our website for more details. The current special ...
(Date:12/25/2014)... Recently, BellasDress has launched ... wedding dresses. BellasDress has chosen their best-selling lace wedding ... for the holiday season. , Now, BellasDress.com features ... gowns here at discount prices. The business hopes everyone ... website. , “All our elegant products are ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... According to the latest issue of Archives of Pediatrics & ... in the age group of two to six years old ... to the same in movies or if parents smoked as ... evening, children two to six years old were nearly four ...
... congenital deformities that arise in the closure of the ... most common forms of neural tube defects seen. // ... brain deformation in anencephaly. ,Although the defect can ... done to correct the defect. The condition usually results ...
... Anbumani Ramadoss Monday said that the government would ... programme// as it has been emerging as a ... function of an Indian Council of Medical Research ... laboratory diagnosis of leptospirosis at the regional ICMR ...
... Deaconess Medical Center had developed a novel way to ... very cost effective manner. They had reported in the ... information from the heartbeats// to develop the procedures that ... problems associated with it. ,Known as a “sleep ...
... the body to fight against specific diseases. The development of ... exposure to agents that cause the disease.// On exposure to ... next time an infection occurs and combat it more effectively ... the development of immunity to asthma as well. Scientists believe ...
... A.R. Rahman Saturday launched 'TB Sangharsh', the first Indian ... to create awareness about the disease here. // ... for the International Stop TB Partnership, met patients in ... about the treatments available and encouraged them to avail ...
Cached Medicine News:Health News:Teaching the immune system to fight diseases is the key to reducing childhood infections 2
(Date:12/24/2014)... and FARMINGTON, Conn. , Dec. ... MKT: PTN), a biopharmaceutical company developing targeted, receptor-specific ... significant unmet medical need and commercial potential, today ... placement of 2,050,000 shares of its common stock ... of its common stock.  Funds under the management ...
(Date:12/24/2014)... DIEGO , Dec. 23, 2014 ResMed (NYSE: ... significant patent infringement action against Chinese medical device manufacturer BMC ... (ITC) ruled today that BMC,s masks listed below infringe ResMed,s ... or selling these masks in the United States ... iVolve N2 nasal mask , Willow nasal pillows mask ...
(Date:12/24/2014)... 2014  The American Diabetes Association is recommending ... people with diabetes and that all people with ... statins, in keeping with recent changes to guidelines ... College of Cardiology (ACC) and American Heart Association ... recent changes to the Association,s annual revised Standards ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4
... , ... Reportlinker.com announces that a new market research report ... Devices - Trends & Opportunities Worldwide , ... new concerns, and adequate funding have transformed the ...
... , NEW YORK, ... research report is available in its catalogue: , ... , http://www.reportlinker.com/p0164273/Radiopharmaceuticals---A-US-and-European-Market-Analysis.html , The market for radiopharmaceuticals ... efficiency, acceptance and utilization of nuclear medicine equipment, as ...
Cached Medicine Technology:Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 2Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 3Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 4Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 5Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 6Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 7Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 8Reportlinker Adds Trauma Devices - Trends & Opportunities Worldwide 9Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 2Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 3Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 4Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 5Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 6Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 7Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 8Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 9Reportlinker Adds Radiopharmaceuticals - A US and European Market Analysis 10
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: