Navigation Links
Compounded outcomes associated with comorbid Alzheimer's disease & cerebrovascular disease
Date:7/3/2014

LEXINGTON, Ky. (July 3, 2014) -- Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies.

The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research & Therapy, have potentially significant implications for patients with both disorders.

Both papers studied CVD in Alzheimer's disease mouse models using different lifestyle factors.

Paul Murphy, Ph.D, and his group studied the combined effects of type 2 diabetes, Alzheimer's disease, and cerebrovascular disease in a novel mouse genetic model.

Donna Wilcock, Ph.D, and her group used a different mouse model to study the effects of Alzheimer's disease and hyperhomocysteinemia on cognition. An elevated level of homocysteine is associated with a number of disease states, including CVD.

According to Wilcock, both papers came to similar conclusions.

"We found that, while the primary Alzheimer's pathologies were unchanged, the learning and memory outcomes were significantly worse. In other words, in our mouse models, the cognitive effects of Alzheimer's disease combined with cerebrovascular disease were compounded both in terms of severity and the speed of decline," Wilcock says.

Murphy emphasizes the significance of the findings, particularly since approximately 40% of Alzheimer's patients also have cerebrovascular disease.

"We are really excited about these results," Murphy said. "Until now, we have had almost no way to study how Alzheimer's and cerebrovascular disease interact. These new mouse models give us a way to test ideas about the disease, and ultimately develop ways to treat it."


'/>"/>

Contact: Laura Dawahare
laura.dawahare@uky.edu
859-257-5307
University of Kentucky
Source:Eurekalert

Page: 1

Related medicine news :

1. In children born with severe heart defect, surgical management has little effect on neuro outcomes
2. Early treatment improves outcomes in rare, often undiagnosed form of encephalitis
3. Intensivists at night improve patient outcomes in some ICUs, says Pitt/UPMC team
4. Phone contact with nurses linked with better outcomes for women with gestational diabetes
5. Group B streptococcal meningitis has long-term effects on childrens developmental outcomes
6. Hospital volume and surgeon specialty influence patient outcomes
7. MDS researchers join forces to advance patient treatments and outcomes
8. Future reproductive outcomes for women who have had an ectopic pregnancy
9. Obesity, larger waist size associated with better outcomes in heart failure patients
10. ACL reconstruction technique improves outcomes in pediatric patients
11. Newer hip reconstruction technique provides good outcomes for athletes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... February 23, 2017 , ... Curemark, LLC announced today ... efficacy of CM-AT in children aged 3-8 with Autism, is now enrolling at three ... enrolling children across the United States. , “There are currently no approved drugs ...
(Date:2/22/2017)... ... February 22, 2017 , ... When it came ... contact center in Georgia, PENETRON Specialty Products (PSP) provided the solution. January’s grand ... recently invested $51 million to purchase and renovate the 185,000 square-foot office complex, ...
(Date:2/22/2017)... ... 2017 , ... The Waismann Method® is providing a faster, safer, ... fallen victim to America’s opioid epidemic. Now, opiate dependent individuals can be treated in ... from the shame, stigma, and harmful labeling believed to prevent many of ...
(Date:2/22/2017)... N.J. (PRWEB) , ... February 22, 2017 , ... ... a one-size-fits-all approach, leads to fewer trips the emergency room, fewer hospital admissions, ... The American Journal of Managed Care® (AJMC®) finds. The study can be found ...
(Date:2/22/2017)... ... , ... Doctors on Liens is continuing its steady expansion of medical specialties ... at North Valley Eye Medical Group in Mission Hills . Eye injuries and ... injury cases. These injuries have a major impact on the quality of life ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... -- Nevro Corp. (NYSE: NVRO), a global medical device company ... chronic pain, today reported financial results for the three months ... 2016 Accomplishment & Highlights: Achieved revenue of ... 228% as reported, over the prior year U.S. ... over the prior year International revenue of ...
(Date:2/23/2017)... REDWOOD CITY, Calif. , Feb. 23, 2017 ... specialty pharmaceutical company focused on the development and ... moderate-to-severe acute pain, announced that it will release ... close on Thursday, March 2nd, 2017. AcelRx management ... p.m. Eastern Time (1:30 p.m. Pacific Time) on ...
(Date:2/23/2017)... , Feb 23, 2017 ... Research and Markets has announced the ... Industry Forecast to 2025" report to their offering. ... of around 1.8% over the next decade to reach approximately $12.8 billion ... estimates and forecasts for all the given segments on global as well ...
Breaking Medicine Technology: