Navigation Links
Compounded outcomes associated with comorbid Alzheimer's disease & cerebrovascular disease
Date:7/3/2014

LEXINGTON, Ky. (July 3, 2014) -- Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies.

The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research & Therapy, have potentially significant implications for patients with both disorders.

Both papers studied CVD in Alzheimer's disease mouse models using different lifestyle factors.

Paul Murphy, Ph.D, and his group studied the combined effects of type 2 diabetes, Alzheimer's disease, and cerebrovascular disease in a novel mouse genetic model.

Donna Wilcock, Ph.D, and her group used a different mouse model to study the effects of Alzheimer's disease and hyperhomocysteinemia on cognition. An elevated level of homocysteine is associated with a number of disease states, including CVD.

According to Wilcock, both papers came to similar conclusions.

"We found that, while the primary Alzheimer's pathologies were unchanged, the learning and memory outcomes were significantly worse. In other words, in our mouse models, the cognitive effects of Alzheimer's disease combined with cerebrovascular disease were compounded both in terms of severity and the speed of decline," Wilcock says.

Murphy emphasizes the significance of the findings, particularly since approximately 40% of Alzheimer's patients also have cerebrovascular disease.

"We are really excited about these results," Murphy said. "Until now, we have had almost no way to study how Alzheimer's and cerebrovascular disease interact. These new mouse models give us a way to test ideas about the disease, and ultimately develop ways to treat it."


'/>"/>

Contact: Laura Dawahare
laura.dawahare@uky.edu
859-257-5307
University of Kentucky
Source:Eurekalert

Page: 1

Related medicine news :

1. In children born with severe heart defect, surgical management has little effect on neuro outcomes
2. Early treatment improves outcomes in rare, often undiagnosed form of encephalitis
3. Intensivists at night improve patient outcomes in some ICUs, says Pitt/UPMC team
4. Phone contact with nurses linked with better outcomes for women with gestational diabetes
5. Group B streptococcal meningitis has long-term effects on childrens developmental outcomes
6. Hospital volume and surgeon specialty influence patient outcomes
7. MDS researchers join forces to advance patient treatments and outcomes
8. Future reproductive outcomes for women who have had an ectopic pregnancy
9. Obesity, larger waist size associated with better outcomes in heart failure patients
10. ACL reconstruction technique improves outcomes in pediatric patients
11. Newer hip reconstruction technique provides good outcomes for athletes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Texas (PRWEB) December 26, 2014 Yisrayl Hawkins, ... written an open letter in light of the Ferguson, Missouri ... history of civil unrest and explains why it has only ... reason mankind was even created. He says there is a ... detail. Yisrayl also says there is a set of rules, ...
(Date:12/26/2014)... Philadelphia, PA (PRWEB) December 26, 2014 ... to Work in the state of Pennsylvania for 2014. ... the first statewide programs of its kind in the ... Pennsylvania Foundation, the Pennsylvania Department of Community and Economic ... Human Resource Management and the Central Penn Business Journal. ...
(Date:12/25/2014)... 26, 2014 The click ... beauty, strength and durability. Today, the business announces ... is valid until Jan. 30, 2015. , Click ... traditional hardwood. BambooFlooringChina.com is a well-known brand in ... worldwide to find a reliable bamboo flooring supplier. ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of wedding dresses and ... of black one-shoulder cocktail dresses . In addition, all ... at discounted prices, up to 70% off. , ... weeks only. You know, we have thousands of frequent callers ... new items can visit our website for more details. The ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Helen Harris’ ... in Woodland Hills, California after an 8 year battle ... on Christmas Eve evening in her home in Woodland ... metastatic breast cancer. , As the ... forty years, she pioneered and championed many of today's ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... , ... "Company") (Nasdaq: CMED ), a leading China-based,medical device company ... its unaudited financial results,for the second fiscal quarter ended September ... on March 31, 2010 ("FY2009"). , , ...
... Speaker Nancy Pelosi issued the following statement tonight on ... , "The Senate health insurance reform bill is ... quality health care available to all Americans. House Democrats ... and to working together to achieve historic reforms that ...
... 18 AmeriCares and Boeing today delivered an emergency shipment ... are still reeling from the devastation caused by back-to-back storms ... storms have been slow to recede, creating a breeding ground ... living in crowded evacuation centers, the threat of infectious diseases ...
... Nov. 18 Smoking cigarettes not only contributes to lung ... spine problems, according to recent studies and observations from leading ... to "kick the habit" during the Nov. 19 Great American ... Cancer Society. Throughout this month, Dr. Karahalios will offer a ...
... A "model" tobacco cessation benefit offered to Massachusetts, ... smoking rates in only two and a half years, ... attacks, hospitalizations for asthma and COPD, and a significant ... Tobacco Cessation and Prevention Program (MTCP) found that up ...
... , BEDMINSTER, N.J., Nov. 18 GettingHired, ... for people with disabilities, announced today that it has secured ... of the largest disability employment portal in the USA as ... new return to work initiative supporting the long term disability ...
Cached Medicine News:Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 2Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 3Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 4Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 5Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 6Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 7Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 8Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 9Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 10Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 11Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 12Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 13Health News:China Medical Technologies Reports Second Fiscal Quarter Financial Results 14Health News:AmeriCares and Boeing Deliver Emergency Relief Supplies to the Philippines 2Health News:Smoking Contributes to Back Pain and Ineffective Surgical Treatments 2Health News:Smoking Contributes to Back Pain and Ineffective Surgical Treatments 3Health News:Massachusetts' 'Model' Tobacco Cessation Benefit Spurs Unprecedented Drop in Smoking Rates, Heart Attacks, Asthma, and Birth Complications 2Health News:Massachusetts' 'Model' Tobacco Cessation Benefit Spurs Unprecedented Drop in Smoking Rates, Heart Attacks, Asthma, and Birth Complications 3Health News:GettingHired Announces Additional Funding for Continued Growth as Well as R&D of New Product for Long Term Disability and Workers' Comp. 2Health News:GettingHired Announces Additional Funding for Continued Growth as Well as R&D of New Product for Long Term Disability and Workers' Comp. 3
(Date:12/24/2014)... -- Commonwealth Cornerstone Group (CCG) today announced the completion of an ... help fund the expansion and consolidation of healthcare services provided ... . PHN is the largest federally qualified ... is the largest employer in Sharon,s ... Currently, PHN Sharon offers scattered services out of ...
(Date:12/24/2014)... , Dec. 24, 2014 Soligenix, ... late-stage biopharmaceutical company developing products that address unmet ... and biodefense, announced today that on December 24, ... offering. The Company raised approximately $2.3 ... intends to use the net proceeds from the ...
(Date:12/24/2014)... Mich. , Dec. 24, 2014  Diplomat Pharmacy, ... independent specialty pharmacy, is proud to announce Jennifer ... quality at Diplomat, will take office as the president ... The formal induction ceremony will take place Feb. 28, ... will be held at the Renaissance Center in ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3
... - Positive data on subcutaneous administration show potential ... CHICAGO, June 04, 2007 /PRNewswire-FirstCall/ -- Millennium,Pharmaceuticals, Inc. ... the market-leading therapy for patients with,multiple myeloma (MM) ... data include results from a Phase II trial ...
... CHICAGO, June 04, 2007 /PRNewswire/ -- GlaxoSmithKline ... of pazopanib in,advanced or metastatic renal cell ... (STS). These trials were presented at the,43rd ... Clinical Oncology,(ASCO) in Chicago. The results observed ...
Cached Medicine Technology:New Data on Market-Leading Velcade (Bortezomib) for Injection,Further Strengthen Role in Previously Treated Multiple Myeloma 2New Data on Market-Leading Velcade (Bortezomib) for Injection,Further Strengthen Role in Previously Treated Multiple Myeloma 3New Data on Market-Leading Velcade (Bortezomib) for Injection,Further Strengthen Role in Previously Treated Multiple Myeloma 4New Data on Market-Leading Velcade (Bortezomib) for Injection,Further Strengthen Role in Previously Treated Multiple Myeloma 5New Data on Market-Leading Velcade (Bortezomib) for Injection,Further Strengthen Role in Previously Treated Multiple Myeloma 6New Data on Market-Leading Velcade (Bortezomib) for Injection,Further Strengthen Role in Previously Treated Multiple Myeloma 7GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma 2GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma 3GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma 4GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma 5GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma 6GSK'S Pazopanib Shows Positive Results in Patients with Advanced,Renal Cell Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma 7
... Pre and Post High Vacuum Autoclaves. The ... to cover a large of applications for ... as private clinics and dental offices. This ... medical and surgical materials such as packed ...
... The Heidelberg Retina Tomograph is a ... and analysis of three-dimensional images of ... quantitative assessment of the retinal topography ... The most important clinical routine application ...
Portable, extremely small size and weight (5.8 kg), fits into a pilot case, mounts directly on any standard I/V pole, simple tubing system (reusable or disposable)....
... the isotope used in Theraseed devices. ... an uncooked grain of rice, are ... Within just three months it has ... and has lost almost all of ...
Medicine Products: