Navigation Links
Compound shows promise against intractable heart failure
Date:2/11/2010

A chemical compound found normally in the blood has shown promise in treating and preventing an intractable form of heart failure in a mouse model of the disease, report researchers at the University of Illinois at Chicago College of Medicine.

The study is published in the February issue of Circulation.

More than five and half million Americans have heart failure, according to the American Heart Association, and 670,000 new cases are diagnosed each year.

In heart failure the heart is unable to pump effectively and cannot meet the body's need for blood and oxygen. It is really two diseases, each with about half of all patients, says Dr. Samuel Dudley, professor of medicine and physiology at UIC and chair of the section of cardiology. Systolic heart failure occurs when the heart can no longer contract effectively. In diastolic heart failure, the heart is unable to relax after contraction.

"Although we have a number of treatments for systolic heart failure, there are no approved treatments at all for diastolic heart failure, a deadly disease with a 60 percent mortality rate five years after diagnosis," said Dudley.

Hypertension is the cause in the overwhelming majority of diastolic heart failure cases.

"We know from previous studies that nitric oxide (NO) is necessary for blood vessel relaxation," said Dudley, "and that hypertension can lead to a decrease of NO in blood vessels."

Dudley and his colleagues knew that -- in blood vessels -- the problem was depletion of a chemical called tetrahydrobiopterin, or BH4, which is needed for the tissues to make NO.

"We decided to try thinking of the heart as a huge blood vessel that might also be unable to make the NO it needed due to long-term hypertension, and see if adding BH4 could make a difference," said Dudley.

They found that by giving mice BH4 they were not only able to prevent diastolic heart failure from developing, but to restore function to the heart after the fact.

"We are very excited about the possibilities of developing therapies for human heart failure based on BH4," said Dudley. BH4 has already been shown to be safe in FDA trials, in a formulation currently used to treat phenylketonuria, a genetic condition.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Sugary Sodas High in Diabetes-Linked Compound
3. Red wine compound shown to prevent prostate cancer
4. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
7. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
8. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
9. Cannabis Compound May Stop Metastatic Breast Cancer
10. Prostate Cancer Treatments Often Compound Existing Health Problems
11. Pharmacopeia and GlaxoSmithKline Collaboration Identifies Two Additional Lead Compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2020)... ... 11, 2020 , ... Soterius, Inc., a global provider of ... a new, significantly larger business premises in Lawrenceville, NJ. The move supports the ... of digital technology platforms. , “As our customer base and offerings continue to ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... Expanded Second Edition: From Sourcing to Butchery, Mindful Meat Eating for the Modern ... by New Society Publishers, this new version brings discussions of responsible meat production, ...
(Date:2/10/2020)... FORT WORTH, Texas (PRWEB) , ... February 10, ... ... Viner has been named vice president in the company’s healthcare division. In this ... expertise, as well as guide the company’s continued healthcare product development. , ...
(Date:2/10/2020)... ... February 10, 2020 , ... Thousand Oaks, CA. ... use with the Legacy™ and InterActive™ systems and is now available for sale ... patients and more freedom of choice for your screw retained restorations. , “We’re ...
(Date:2/10/2020)... ... February 10, 2020 , ... Rimidi , ... populations, today announced its founder and chief health innovator, Lucienne Ide , ... Health IT . Established in 2016, the award recognizes influential women who harness ...
Breaking Medicine News(10 mins):
(Date:2/14/2020)... ... , ... Gramercy Dental Center , located at 118 East 19th Street ... expansive menu of dental services in one convenient location. Dr. Mark Don brings over ... cosmetic and restorative dentist Dr. Patricia Sciortino. Together, they are equipped to offer a ...
(Date:2/14/2020)... Va. (PRWEB) , ... February 14, 2020 , ... ... Pharmaceuticals, Biologics and Medical Devices, An FDAnews Webinar , Tuesday, Feb. 25, 2020, ... importation issues with pharmaceuticals and medical devices? If one does not know the ...
(Date:2/13/2020)... ... February 13, 2020 , ... The global market for ... from the estimated value of $93.9 billion in 2010, according to a new report ... , “Growth in this market is driven by an aging population and a ...
Breaking Medicine Technology: