Navigation Links
Compound enhances cancer-killing properties of agent in trials
Date:6/9/2010

Adding a second agent may make a new, experimental anti-cancer drug effective against a wide range of cancers, researchers at the University of Illinois at Chicago College of Medicine have found.

A man-made compound called ARC was shown by UIC researchers in 2006 to cause tumor cells to die while leaving normal cells unharmed. ARC, an acronym for its long chemical name, resembles one of the chemical building blocks of DNA. Andrei Gartel, associate professor of molecular genetics, and coworkers found it by screening more than 2,000 compounds for their ability to inhibit a key step in the cell cycle.

Now Gartel's laboratory has found that adding ARC may greatly broaden the activity of an anti-cancer agent from Abbott Laboratories that is currently in FDA trials, making it effective in killing a wide range of cancer types.

The results are published online in the journal Molecular Cancer Therapeutics.

In the earlier study, ARC was able to induce apoptosis, or cell suicide, in cancer cells, and only did so to a much lesser extent in normal cells, said Gartel, who is also principal author on the new study.

ARC works mainly by targeting MCL-1, a member of the Bcl-2 family of cellular molecules, which protect cancer cells from the apoptosis induced by anti-cancer drugs. Gartel and his colleagues were interested in whether ARC might be able to improve the activity of Abbott's investigational drug ABT-737, which inhibits several other members of the Bcl-2 family, but not MCL-1.

ABT-737 alone is effective against some small-cell lung cancer cell lines and leukemia cells, but ineffective against other cancer cells, including renal and prostate cancer cell lines.

Gartel and his colleagues knew from other research that because MCL-1 has a protective effect, preventing apoptosis, ABT-737 was not effective in cancer cells with active MCL-1. They decided to see if ARC, which inactivates MCL-1, could work together with ABT-737 to kill a wider range of cancer cells.

"We found that we could use much smaller concentrations of both agents together and effectively target and kill a broad range of cancer cell lines," said Gartel. "This combination of agents shows tremendous synergy."

Reducing the dose can lessen side-effects of potential therapies, Gartel said.

The new study suggests that ARC may have potential as an anti-cancer agent in combination therapies with ABT-737, targeting an important cellular pathway, Gartel said.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Spice Compounds May Stem Tumor Growth
2. Compound found that targets wide range of viruses
3. Quality of compounded medicines supported by new standards
4. Compounds Identified That Might Treat Nerve Diseases
5. Prenatal exposure to flame-retardant compounds affects neurodevelopment of young children
6. Marijuana Compounds Could Beat Back Brain Cancer
7. New compound improves cognitive decline, symptoms of Alzheimers disease in rodents
8. Compound shows promise against intractable heart failure
9. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
10. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
11. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Goodcents Deli Fresh Subs today announced the opening ... 4210 SW 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned ... owns three other locations in the Topeka and Bonner Springs, Kan. area. , ...
(Date:6/23/2017)... ... ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows , ... society in 11 countries across the Middle East and South Asia to embark on ... knowledge and ideas with the leading minds in their fields. , For the ...
(Date:6/23/2017)... FL (PRWEB) , ... June 23, 2017 , ... American ... award winning series, which is slated to air fourth quarter 2017. American Farmer airs ... D.A. Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed ... clients throughout eastern Texas, is announcing the launch of a new charity drive to ... statistics in the United States reveal that an estimated 252, 710 new cases of ...
(Date:6/22/2017)... CA (PRWEB) , ... June 22, 2017 , ... Plastic ... named as a Top Doctor for 2017. Each year, research and information firm, Castle ... First winning the title in 2015, this marks the 3rd time that Dr. ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)...  ivWatch LLC, a medical device company focused on ... is pleased to announce it was the Bronze Winner ... and Equipment at the 2017 Medical Design Excellence Awards ... The award was presented by Medical Device and Diagnostics ... New York during MD&M East, ...
(Date:6/13/2017)... WARSAW, Ind. , June 13, 2017 Zimmer ... in musculoskeletal healthcare, today announced that the U.S. Food and ... Letter dated June 3, 2015 relating to its ... "The successful clearance of ... China manufacturing facility is a measure of the ...
(Date:6/10/2017)... Ala. , June 9, 2017  Shane K. Burchfield, DPM, ... recognized for excellence as a Podiatrist in Alabama ... Podiatry at Family First Foot Care. He brings over 20 years ... medicine, pain management and healthcare, to his role. ... First Foot Care, PC is pleased to welcome you ...
Breaking Medicine Technology: