Navigation Links
Compound developed by scientists protects heart cells during and after attack
Date:2/7/2013

JUPITER, FL, February 7, 2013 Using two different compounds they developed, scientists from the Florida campus of The Scripps Research Institute (TSRI) have been able to show in animal models that inhibiting a specific enzyme protects heart cells and surrounding tissue against serious damage from heart attacks. The compounds also protect against additional injury from restored blood flow after an attack, a process known as reperfusion.

The study, which was led by Philip LoGrasso, a professor and senior scientific director of discovery biology at Scripps Florida, appears in the February 8, 2013 print edition of The Journal of Biological Chemistry.

A heart attack severely restricts blood supply, starving heart cells and surrounding tissue of oxygen, which can cause enormous damage in relatively little timesometimes in just a few minutes. Known as an ischemic cascade, this drop-off of oxygen results in a sudden crush of metabolic waste that damages cell membranes as well as the mitochondria, a part of the cell that generates chemical energy and is involved in cell growth and death.

Unfortunately, restoring blood flow adds significantly to the damage, a serious medical issue when it comes to treating major ischemic events such as heart attack and stroke. Reperfusion re-invigorates production of free radicals and reactive oxygen species that attack and damage cells, exacerbating inflammation, turning loose white blood cells to attack otherwise salvageable cells and maybe even inducing potentially fatal cardiac arrhythmias.

The new study found that inhibiting the enzyme, c-jun-N-terminal kinase (JNK), pronounced "junk," protected against ischemic/reperfusion injury in rats, reducing the total volume of tissue death by as much as 34 percent. It also significantly reduced levels of reactive oxygen species and mitochondrial dysfunction.

In earlier studies, TSRI scientists found that JNK migrates to the mitochondri
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. TriMix Laboratories Announces New TriMix-gel Partnership with US Compounding
2. Scripps Florida scientists develop new compound that reverses fatty liver disease
3. Women’s Excellence in Bladder Control Partners with University Compounding Pharmacy in Troy, MI to Help Women with Chronic Pelvic Pain Conditions
4. Compounding Pharmacists Oppose Greater U.S. Oversight
5. Taiho Pharmaceutical unveils data on 8 novel anticancer compounds
6. Second Compounding Pharmacy Shut Down in Massachusetts
7. Compounds activate key cancer enzyme to interfere with tumor formation
8. Green tea compound shows promise for tackling cancer
9. Red wine compound could help seniors walk away from mobility problems
10. Breast-Milk Compound May Shield Babies From HIV
11. Natural Sciences Repository Publishes Chromatography and Acidic Compounds Resources
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Compound developed by scientists protects heart cells during and after attack
(Date:11/26/2014)... (PRWEB) November 26, 2014 For those with ... new LES MILLS BODYPUMP™ classes at the University ... the workout they've been looking for. The 45- 60 minute ... Anschutz Health and Wellness Center fitness club memberships. , LES ... workouts are fast-paced and are aimed at fast results ...
(Date:11/26/2014)... November 26, 2014 News Facts ... expanded capabilities at RSNA 2014 in Chicago. The ... and share diagnostic images, photos, videos and documents ... booth #8107 will learn more about these innovative ... technologies and partner initiatives – that enable more ...
(Date:11/26/2014)... 2014 One of the most important ... point in her life is choosing the ideal wedding ... for ladies to purchase high quality outfits. Today, BellasDress.com ... People now can pick their suitable bridesmaid gowns here ... always make ladies look scintillating and highlight all their ...
(Date:11/26/2014)... (HealthDay News) -- Vultures have developed highly specialized ways ... eating dead animals, researchers report. The new research ... faces and in the guts of 50 turkey vultures ... the faces of the vultures had more than 500 ... guts, the study found. The findings suggest that ...
(Date:11/26/2014)... Nov. 25, 2014 (HealthDay News) -- The number of emergency ... million in 2010 to a record 136 million in 2011, ... The findings also showed that fewer people were going ... were identified as needing medical care within two hours of ... percent, according to the research. Sixty percent of patients ...
Breaking Medicine News(10 mins):Health News:LES MILLS BODYPUMP™ classes come to the University of Colorado Anschutz Health and Wellness Center 2Health News:Perceptive Software to Demonstrate New Medical Content Management Features and Capabilities at RSNA 2014 2Health News:Perceptive Software to Demonstrate New Medical Content Management Features and Capabilities at RSNA 2014 3Health News:Royal Blue Bridesmaid Dresses Now Are Available for Christmas at BellasDress.com 2Health News:ER Visits on the Rise, Study Reports 2
... three-dimensional image of the AIDS virus, with lots of protein ... immune cells – An extraordinary work since past 25 year ... AIDS research could boost the development of vaccines that will ... proteins. In fact, said principal investigator and FSU Professor Kenneth ...
... found that daily intake of alcohol may reduce the risk ... the research has concluded that it is applicable only for ... raises important questions about drinking patterns and heart health among ... should be interpreted with caution and should not be used ...
... over 3500 and an incalculable number of people injured after ... cope with the injured and the dead. ,The quake ... city of Yogyakarta which is near the southern coast of ... left the city in shambles, cutting off communications and road ...
... British Pregnancy Advisory Service (BPAS) has announced that nearly a ... nine weeks of pregnancy had involved// the abortion pill, also ... figures reveal that the demand for the abortion pill in ... women undergoing the procedure last year.,BPAS said the number of ...
... Ashodya Mahila Samanwayas Samithi (AMSS), is launching a smart and ... ,As many as 500 sex workers are set ... first time in the country this scheme is to start ... cards. The smart card project, the brainchild of Karnataka Health ...
... green substance inside the body of a lobster commonly known ... by may others as a waste//, unhealthy product. The health ... against eating too much of lobster tomalley. ,The ... serve as a liver and pancreas for lobster, can sometimes ...
Cached Medicine News:Health News:Three-Dimensional Image Of AIDS Virus – BY FSU Researcher 2Health News:Three-Dimensional Image Of AIDS Virus – BY FSU Researcher 3Health News:Daily Intake Of Alcohol Reduces Heart Disease In Men Than Women 2Health News:Indonesian Earthquake – Story of Destruction, Death and Disease 2Health News:Record Number Of Women Use Abortion Pills 2Health News:Sex Workers To Have Smart Health Card 2
(Date:11/26/2014)... Nov. 26, 2014  Aridis Pharmaceuticals, Inc., a ... therapies for infectious diseases, announced today the addition ... recognized key opinion leader in the areas of ... board. Founder and Chief Executive Officer, ... Dr. Opal,s extensive experience investigating bacterial toxins and ...
(Date:11/26/2014)... YORK and LONDON , ... of market intelligence, MarketResearch.com is pleased to announce the ... and Consultancy focusing on the active pharmaceutical ingredient (API) ... visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . In IQ4I,s ... – Forecast to 2020 , IQ4I ...
(Date:11/26/2014)... 2014  At the American Dental Association,s Annual Meeting ... KaVo Kerr Group was honored to be part of ... opportunity to see and test the Best of Class ... lectures on the latest developments in dental technology. This ... DEXIS CariVu Caries Detection Device and Kerr Demi ™  ...
Breaking Medicine Technology:Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3
... March 18, 2011 ViroPharma Incorporated (Nasdaq: ... Products for Human Use (CHMP) of the European Medicines ... plenary meeting in March 2011 recommending approval of a ... adults and adolescents with hereditary angioedema (HAE) for routine ...
... 18, 2011 Quest Diagnostics Incorporated (NYSE: ... information and services, and Celera Corporation (Nasdaq: ... diagnostics discovery and development, announced today that they have ... Diagnostics will acquire Celera for $8 per share, representing ...
Cached Medicine Technology:ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 2ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 3ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 4ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 5ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 6Quest Diagnostics to Acquire Celera, Strengthening Position as World's Leading Innovator in Molecular Diagnostics and Development 2Quest Diagnostics to Acquire Celera, Strengthening Position as World's Leading Innovator in Molecular Diagnostics and Development 3Quest Diagnostics to Acquire Celera, Strengthening Position as World's Leading Innovator in Molecular Diagnostics and Development 4Quest Diagnostics to Acquire Celera, Strengthening Position as World's Leading Innovator in Molecular Diagnostics and Development 5Quest Diagnostics to Acquire Celera, Strengthening Position as World's Leading Innovator in Molecular Diagnostics and Development 6Quest Diagnostics to Acquire Celera, Strengthening Position as World's Leading Innovator in Molecular Diagnostics and Development 7
The first Ethyl-2-Cyanoacrylate tissue adhesive in a tube that is more economical than sutures!...
Redwood Toxicology Laboratory is one of the world's premier forensic drug detection laboratories offering its customers scientifically accepted, legally defensible drug detection services....
... Affinity pacemaker family offers ... truly automatic devices. Featuring ... of advanced technologies ever ... pacemaker incorporates the exclusive ...
... pacemaker family offers some ... automatic devices. Featuring the ... advanced technologies ever seen, ... incorporates the exclusive ventricular ...
Medicine Products: