Navigation Links
Complications Found in Proposed Prostate Cancer Treatment
Date:5/1/2008

Efforts to hinder a protein called IGF-1 not entirely successful, studies find

THURSDAY, May 1 (HealthDay News) -- The idea that prostate cancer can be treated successfully just by blocking the activity of a protein called insulin-like growth factor (IGF-1) has been undermined by two new studies.

IGF-1 blockage is a goal being pursed by a number of drug companies and academic researchers, stimulated by studies showing an association between high levels of the protein and prostate cancer risk. Many efforts are aimed at blocking the receptors for IGF-1 in prostate cancer cells.

The new studies showing that blocking IGF-1 receptors isn't as simple a matter as might be wished are published back to back in the May 1 issue of Cancer Research.

One of the studies, by a group led by Norman Greenberg, a member of the clinical research division at the Fred Hutchinson Cancer Research Center in Seattle, found an unexpected interaction with a tumor suppressor gene, p53. The researchers created mice whose prostate cells lacked receptors for IGF-1 and crossed them with mice whose P53 gene function was crippled.

"When the function of p53 is abrogated, the cancers seem to accelerate," Greenberg said. "So when you interfere with the IGF-1 receptor, you might be taking the foot off the brake."

That wouldn't matter in human males whose p53 genes were working properly, Greenberg said. "What we are suggesting is that when p53 is compromised, patients might not respond as indicated," he said.

This might mean that a check of p53 function in someone with prostate cancer might be needed before IGF-1 blockage therapy is started, Greenberg said. That idea has to be checked out, he said.

"So we would get data on a patient's tumor before treatment and after treatment, and see if the status of p53 shows whether it would respond more or less to IGF-1 treatment," Greenberg said.

The other study, this one led by Dr. Pinchas Cohen, chief of pediatric endocrinology at the University of California, Los Angeles, also used mice bred to develop prostate cancer, with some also bred to lack IGF-1 receptors.

"The conventional wisdom was that without the IGF receptors, the tumors would fail to develop or be much smaller," Cohen said. "What happened was that they were not reduced in size. In fact, they were exactly the same size."

Low IGF-1 levels in the mice were accompanied by higher levels of growth hormone and insulin, which stimulated growth of the cancer cells, Cohen said.

"This doesn't argue against IGF-1 blockage as a treatment," he said. "But it shows the need for targeting multiple pathways. As the cancers find ways to overcome IGF-1 blockage, it should be used in conjunction with other therapies."

More information

Learn more about prostate cancer from the U.S. National Cancer Institute.



SOURCES: Norman Greenberg, Ph.D., Fred Hutchinson Cancer Research Center, Seattle; Pinchas Cohen, M.D., professor and chief, pediatric endocrinology, University of California, Los Angeles; May 1, 2008, Cancer Research


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Viscosity Enhancers Curb Bleeding Complications
2. FDA Examines LASIK Surgery Complications
3. Minimally invasive pancreas surgery leads to fewer complications, study finds
4. Laparoscopic Surgery on Pancreas Has Fewer Complications
5. Sleep Apnea Screening Cuts Surgical Complications
6. Operating Room Nurses are Concerned about Complications Associated with Powdered Gloves
7. Psoriasis Poses Danger for More Serious Complications
8. New Interventional Radiology Treatment Shows Hope for People With Complications from Bone Marrow, Stem Cell Transplants
9. How to effectively avoid many common complications and liver damage in bile duct exploration?
10. Obese Children Face More Complications During Surgery
11. UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... (PRWEB) , ... April 22, ... ... Administration of Eastern Pennsylvania has named PROSHRED® Security of Philadelphia its ... Heron-Doerr, PROSHRED® Philadelphia specializes in providing information destruction , recycling, ...
(Date:4/21/2017)... ... ... Providing broad access to life-saving drugs and rewarding the innovators who develop ... address this problem. , That was the message from Dana Goldman, PhD, Leonard D. ... of Southern California, who served as the keynote speaker for Western University of Health ...
(Date:4/21/2017)... ... April 21, 2017 , ... Brady (NYSE:BRC), a global leader in ... and B-7569 vinyl label materials received certification for the BS5609 British Marine ... remain intact and legible, for use on chemical drums shipped by sea. ...
(Date:4/21/2017)... ... 2017 , ... The VIA Agency , a full-service ... Theravent, Inc. , the makers of a revolutionary new device clinically proven to ... working to expand distribution in anticipation of a national launch. VIA will be ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... exciting new partnership with the highly regarded and well renowned Asian distributor, Discovery ... myTAP & myTAP PAP Nasal Pillow Mask, and will stabilize and strengthen Airway’s ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)...  Cogentix Medical, Inc. (NASDAQ: CGNT), a global ... Uro/Gyn and Gynecology markets with innovative and proprietary ... the Company as Senior Vice President, Marketing & ... Keswani will report directly to Darin Hammers ... is delighted that Ash has joined the Cogentix ...
(Date:4/20/2017)... Research and Markets has announced the addition ... Addressing Production Complexities Through Risk Management and Quality by ... ... Market Prospects: Overcoming Production Complexities Through Risk Management and ... current trends in the global biosimilars market, with a ...
(Date:4/20/2017)... , April 20, 2017  CVS Pharmacy, ... today unveiled a new store design to enhance ... of healthier food, health-focused products and expanded beauty ... to help customers discover new offerings. Together with ... next evolution of the customer experience at CVS ...
Breaking Medicine Technology: