Navigation Links
Complex changes in the brain's vascular system occur after menopause
Date:6/16/2008

COLUMBIA, Mo. Many women experience menopausal changes in their body including hot flashes, moodiness and fatigue, but the changes they don't notice can be more dangerous. In a new study, researchers at the University of Missouri have discovered significant changes in the brain's vascular system when the ovaries stop producing estrogen. MU scientists predict that currently used estrogen-based hormone therapies may complicate this process and may do more harm than good in postmenopausal women.

"Before menopause, women are much more protected from certain conditions such as heart disease and stroke, but these vascular changes might explain why women lose this protection after menopause," said Olga Glinskii, research assistant professor of medical pharmacology and physiology in MU's School of Medicine and lead author of the study. "Because the body eventually will naturally adapt to the loss of estrogen, we advise extreme caution when using estrogen-based therapy in postmenopausal women."

In their study, MU researchers removed the ovaries of pigs, which have a reproductive cycle similar to humans, to create postmenopausal conditions. Two months after the ovaries were removed, they observed dramatic differences in the brain's vascular system. There was a huge loss of micro vessels, and blood vessels became "leaky."

"Eventually, however, the body starts to recognize that it needs blood vessels and starts to adapt through natural responses," said Vladislav Glinskii, assistant professor of pathology and anatomical sciences in MU's School of Medicine, research health scientist at Harry S. Truman Memorial Veterans' Hospital and co-senior author of the study. "If we start adding estrogen to a system that is learning to adapt without it, we upset this transition process. What happens to the vascular system during menopause is complex on many different levels, and we do not know enough to determine the best way to use hormone therapy."

Before menopause, the vascular system depends on estrogen for maintenance. When the body decreases its estrogen production, the body is unable to regulate blood vessels like it did before. After a period of deterioration, the body learns to adapt to the estrogen loss and eventually maintains the system in a different way.

"The vascular system is like a roadmap that is always changing," said Virginia Huxley, director of the National Center for Gender Physiology, professor of medical pharmacology and physiology in MU's School of Medicine, and co-senior author of the study. "The blood vessels are the highways that transport oxygen and other nutrients in our body. After menopause, women are more likely to develop vascular diseases in the 'side streets' or the tiny vessels. In these vessels, the symptoms are more subtle and harder to identify."


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Chromatin remodeling complex connected to DNA damage control
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Primitive Plants Have Complex Sex Life
4. In the Forefront of Research into Protein Folding and Macromolecular Complex Assembly
5. Identification of new genes shows a complex path to cell death
6. CDI-Life Sciences Selected by CJ CheilJedang Corp. to Provide Engineering Design for Major Pharmaceutical Complex in Korea
7. New research tools are too complex for easy answers, researchers say
8. Pharma Product Commercialization: Standardized Team Processes Help Save Complex Drug Launches
9. Drug-Coated Stents Better Than Bare-Metal Ones in Complex Cases
10. Study finds patients with complex fibroadenomas can avoid surgery
11. Super Charge the Skin with Murad Vitalic(R) Featuring Energizing Pomegranate Complex(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... ... has seen a significant spike in their clients' employee participation for their wellness ... health screening by implementing a high-deductible health plan with outcome-based deductible incentives. As ...
(Date:5/25/2016)... ... ... Stern Environmental Group , of Secaucus, New Jersey, working in conjunction ... Real Time Monitoring (RTM) Device. Stern Environmental Group will sell the first monitoring ... use in dormitories, shelters, and nursing homes for real time bedbug monitoring in May ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... (Rudy) Cifolelli has joined the company as Vice President of Sales. Cifolelli’s ... U.S. and international sales in the rapidly expanding field of organizational social engineering. ...
(Date:5/24/2016)... ... ... Jericho Project has named LaToya Williams-Belfort to the position of Chief Development and ... for the nationally-acclaimed nonprofit, working closely with CEO Tori Lyon and the Board of ... roots. , “LaToya Williams-Belfort is joining Jericho at an exciting time of growth ...
(Date:5/24/2016)... ... , ... How to Write Error Free Procedures, **Presented by Ginette M. Collazo ... is known to be the major cause of quality and production losses in many ... human performance problems can be prevented. , How to Write Error Free Procedures, part ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... India , May 25, 2016 ... Review, H1 2016"market research report that provides an ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:5/24/2016)... -- Diana Russell suffers from a form of rheumatoid arthritis ... This disease has put her in a wheelchair, and ... to leave her home.  Because of the size and ... wheelchair.  So if there is a family function, the ... to wait for the bus. Photo - ...
(Date:5/24/2016)... The innovator of COMBO ... s first dual therapy stent, introduces catheters for ... OrbusNeich, a global company specializing in the provision of ... products to treat peripheral artery disease. The JADE™ and ... for lower limb and arteriovenous (AV) fistula intervention. ...
Breaking Medicine Technology: