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Comparison of available breast cancer risk assessment tools shows room for improvement
Date:4/28/2010

ls may take several directions. Studies are looking at additional risk factors, particularly breast density, weight gain, and hormone levels. The authors predict that genome-based research is also likely to yield new risk prediction methods.

To date, however, no existing model is "totally able to discriminate between families that do and do not have mutations or between women who will and will not develop breast cancer," they write. "Steady and incremental improvement in the models are being made, but these changes require revalidation."

In an accompanying editorial, Mitchell Gail, M.D., Ph.D., and Phuong Mai, M.D., of the National Cancer Institute, say that the review offers a useful and informative summary of the various models. They caution, however, that the various models differ in important details and that physicians need to be cognizant of these differences. They conclude that continuing efforts are needed to improve and assess risk models so that they can play a useful role, in concert with preventive interventions, in reducing the burden of breast cancer.


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Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

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