Navigation Links
Comparison of available breast cancer risk assessment tools shows room for improvement
Date:4/28/2010

All the breast cancer risk assessment tools now available have serious limitations when it comes to discriminating between individuals who will and will not develop breast cancer, according to an article published online April 28 in the Journal of the National Cancer Institute.

Assessing a woman's risk of breast cancer is an essential first step in deciding on prevention strategies, which can range from lifestyle changes to removal of a breast. A number of risk assessment tools, or models, are now available. Those that estimate population risk are sufficient for policymakers and insurers, say the authors of this review, led by Eitan Amir, M.B. Ch.B., of Princess Margaret Hospital in Toronto.

"However, for clinicians, it is imperative that a risk assessment tool has a good ability to assess individual risks so that appropriate preventative treatment can be individually tailored," they write.

To provide practicing physicians with an overview of available tools, the authors reviewed the features of six risk assessment models. These include the well-established Gail model, which is based on six risk factors such as age, family history, and age at menopause. The Claus model, also widely used, places a strong emphasis on family history. The BRCAPRO, Jonke, IBIS, and BOADICEA models aim primarily to assess the likelihood of carrying a BRCA gene mutation that predisposes a woman to breast cancer.

All of these models have major limitations, say the authors. Most important is their reliance on known risk factors. Studies have shown that up to 60% of breast cancers arise in the absence of any known risk factors. Also, except for the Gail model, none of the models has been extensively validated, and most do not include nonhereditary factors. The Gail model has limited ability to discriminate between individuals at risk, especially those in higher-risk groups, according to the authors.

Future improvements in risk models may take several directions. Studies are looking at additional risk factors, particularly breast density, weight gain, and hormone levels. The authors predict that genome-based research is also likely to yield new risk prediction methods.

To date, however, no existing model is "totally able to discriminate between families that do and do not have mutations or between women who will and will not develop breast cancer," they write. "Steady and incremental improvement in the models are being made, but these changes require revalidation."

In an accompanying editorial, Mitchell Gail, M.D., Ph.D., and Phuong Mai, M.D., of the National Cancer Institute, say that the review offers a useful and informative summary of the various models. They caution, however, that the various models differ in important details and that physicians need to be cognizant of these differences. They conclude that continuing efforts are needed to improve and assess risk models so that they can play a useful role, in concert with preventive interventions, in reducing the burden of breast cancer.


'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Online Medical Supply Comparison Shopping Service Saves Nursing Homes Money
2. Comparison shows robot-assisted option offers advantages for kidney surgery
3. Scholarships Available for Special Needs Life Quality Plans
4. Individual Dental Insurance Now Available at Highmark Direct Retail Stores in Pittsburgh and Mechanicsburg
5. Free H1N1 Vaccines Available at Concentra Urgent Care
6. Minimally invasive adult liver donation for pediatric transplantation available exclusively
7. Polar Pump: E85 Fuel Now Available in Warroad, Minn., Northernmost Outlet for the Fuel in USA
8. New Cancer Information Available on MyBiopsy.org from the Doctors Who Diagnose Cancer
9. Micromedex CareNotes Available Within the MEDITECH Health Care Information System
10. The PLAC Test is Now Available at ANY LAB TEST NOW North Dallas
11. Web's Newest, Sub-1000 Range of Hot Tubs Now Available For Purchase Online!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... 24, 2017 , ... Come to PAINWeekEnd (PWE) Tampa on May 20 and ... educational and exciting 2-day program. , An attendee at a recent PAINWeekEnd said, ... patients” about the course entitled Ain't Misbehavin': Decreasing and Managing Pain Patient Aberrant Behavior, ...
(Date:4/24/2017)... ... ... “Learning to Use Your SPIRITUAL COMPASS To Navigate Life Issues”: a guide to using ... Life Issues” is the creation of published author, Rachel Jamerson, writer of 25 years, ... USA, and former member of the American Association of Christian Counselors. Rachel studied ...
(Date:4/24/2017)... , ... April 24, 2017 , ... ... development of next generation neuro-thrombectomy systems for the treatment of Acute Ischemic Stroke ... its ANCD BRAIN device as the product advances towards regulatory and clinical phases. ...
(Date:4/22/2017)... (PRWEB) , ... April 22, ... ... Administration of Eastern Pennsylvania has named PROSHRED® Security of Philadelphia its ... Heron-Doerr, PROSHRED® Philadelphia specializes in providing information destruction , recycling, ...
(Date:4/21/2017)... ... 2017 , ... Providing broad access to life-saving drugs and rewarding the innovators ... way to address this problem. , That was the message from Dana Goldman, PhD, ... the University of Southern California, who served as the keynote speaker for Western University ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, Inc. ... providing the Urology, Uro/Gyn and Gynecology markets with innovative ... first quarter ended March 31, 2017 after the market ... The Company will host a conference call and webcast ... Tuesday, May 2, 2017 at 4:30 p.m. Eastern Time ...
(Date:4/18/2017)... DIEGO , April 18, 2017  Astute Medical, ... a case series to be presented at the 2017 ... which begins today and continues through April 22. Physicians ... IGFBP-7 , used to assess risk for acute kidney ... decompensated heart failure (ADHF). Elevated levels ...
Breaking Medicine Technology: