Navigation Links
Comparison of available breast cancer risk assessment tools shows room for improvement
Date:4/28/2010

All the breast cancer risk assessment tools now available have serious limitations when it comes to discriminating between individuals who will and will not develop breast cancer, according to an article published online April 28 in the Journal of the National Cancer Institute.

Assessing a woman's risk of breast cancer is an essential first step in deciding on prevention strategies, which can range from lifestyle changes to removal of a breast. A number of risk assessment tools, or models, are now available. Those that estimate population risk are sufficient for policymakers and insurers, say the authors of this review, led by Eitan Amir, M.B. Ch.B., of Princess Margaret Hospital in Toronto.

"However, for clinicians, it is imperative that a risk assessment tool has a good ability to assess individual risks so that appropriate preventative treatment can be individually tailored," they write.

To provide practicing physicians with an overview of available tools, the authors reviewed the features of six risk assessment models. These include the well-established Gail model, which is based on six risk factors such as age, family history, and age at menopause. The Claus model, also widely used, places a strong emphasis on family history. The BRCAPRO, Jonke, IBIS, and BOADICEA models aim primarily to assess the likelihood of carrying a BRCA gene mutation that predisposes a woman to breast cancer.

All of these models have major limitations, say the authors. Most important is their reliance on known risk factors. Studies have shown that up to 60% of breast cancers arise in the absence of any known risk factors. Also, except for the Gail model, none of the models has been extensively validated, and most do not include nonhereditary factors. The Gail model has limited ability to discriminate between individuals at risk, especially those in higher-risk groups, according to the authors.

Future improvements in risk models may take several directions. Studies are looking at additional risk factors, particularly breast density, weight gain, and hormone levels. The authors predict that genome-based research is also likely to yield new risk prediction methods.

To date, however, no existing model is "totally able to discriminate between families that do and do not have mutations or between women who will and will not develop breast cancer," they write. "Steady and incremental improvement in the models are being made, but these changes require revalidation."

In an accompanying editorial, Mitchell Gail, M.D., Ph.D., and Phuong Mai, M.D., of the National Cancer Institute, say that the review offers a useful and informative summary of the various models. They caution, however, that the various models differ in important details and that physicians need to be cognizant of these differences. They conclude that continuing efforts are needed to improve and assess risk models so that they can play a useful role, in concert with preventive interventions, in reducing the burden of breast cancer.


'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Online Medical Supply Comparison Shopping Service Saves Nursing Homes Money
2. Comparison shows robot-assisted option offers advantages for kidney surgery
3. Scholarships Available for Special Needs Life Quality Plans
4. Individual Dental Insurance Now Available at Highmark Direct Retail Stores in Pittsburgh and Mechanicsburg
5. Free H1N1 Vaccines Available at Concentra Urgent Care
6. Minimally invasive adult liver donation for pediatric transplantation available exclusively
7. Polar Pump: E85 Fuel Now Available in Warroad, Minn., Northernmost Outlet for the Fuel in USA
8. New Cancer Information Available on MyBiopsy.org from the Doctors Who Diagnose Cancer
9. Micromedex CareNotes Available Within the MEDITECH Health Care Information System
10. The PLAC Test is Now Available at ANY LAB TEST NOW North Dallas
11. Web's Newest, Sub-1000 Range of Hot Tubs Now Available For Purchase Online!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, the leading ... with Tennessee Counseling Association. This new relationship allows TherapySites to continue ... Association, adding exclusive benefits and promotional offers. , "TCA is extremely excited about ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: