Navigation Links
Comparison of antipsychotic treatments in adolescents with schizophrenia
Date:2/28/2008

Philadelphia, PA, February 28, 2008 There is a wealth of scientific literature available on the treatment of adults diagnosed with schizophrenia. However, there is a paucity of data to guide the treatment of children and adolescents with schizophrenia. Although the U.S. Food and Drug Administration (FDA) has recently approved the use of aripiprazole and risperidone for adolescents with schizophrenia, few controlled data are available to help guide clinicians regarding the management of children and adolescents with schizophrenia who fail to respond to these standard 'first-line' antipsychotic treatments, according to Dr. Sanjiv Kumra. Dr. Kumra is one of the authors of a new study to be published in the March 1st issue of Biological Psychiatry, which was undertaken to help fill this gap in knowledge.

The authors recruited 39 children, 10-18 years of age, who had already failed to respond to at least two antipsychotic treatments, to participate in a 12-week, double-blind, randomized study the most rigorous of clinical trial designs. After initial assessments, the patients received treatment with either clozapine or high-dose olanzapine (doses that exceed the package insert recommendations) and were monitored for improvement in their symptoms. The researchers discovered that clozapine was approximately twice as likely to produce a treatment response as olanzapine. Both positive symptoms (psychosis) and negative symptoms (blunted emotional response, reduced motivation) responded better to clozapine. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments on the findings: Olanzapine is among the most effective antipsychotic medications, so the distinctive effectiveness of clozapine in this study could be very important.

Dr. Kumra discusses this patient population: The majority of these youth had histories of multiple hospitalizations, extreme violence, suicidality and trauma prior to study enrollment. Without appropriate intervention it is likely that many would have ended up in long-term care institutions, psychiatric prison settings, and/or experienced early death from drug use, violence, or suicide. So, this preliminary data is hopeful, indicating that proper and effective treatment may be available for these adolescents, although there are also concerns.

Both medications produced significant weight gain and associated metabolic abnormalities. Dr. Krystal also adds that clozapine has important side effects that have discouraged its prescription to children. Dr. Kumra agrees, stating that although clozapine is often considered as a treatment of last resort because of its associated risk of agranulocytosis [a severe reduction in the number of white blood cells in the body], the striking symptom reduction observed in this clinical trial make apparent that clozapine has truly revolutionized the care of youth with treatment-refractory schizophrenia.

Dr. Krystal concludes: The long-term risks of medications, such as clozapine and olanzapine, will need to be weighed against their potential benefits. Thus, additional research will be needed to follow-up on this exciting but very preliminary finding.


'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Comparison of obstetric outcomes between on-call and patients own obstetricians
2. Highmark Blue Cross Blue Shield Introduces New Health Plan Comparison Tool for Consumers
3. Highmark Blue Shield Introduces New Health Plan Comparison Tool for Consumers
4. OCuSOFT Refutes Comparison Time-Kill Study Released by Advanced Vision Research
5. Diuretics excel in drug comparison trial involving hypertension/metabolic syndrome
6. Comparison of venlafaxine and SSRIs in the treatment of depression
7. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
8. Antidepressant as Good as Antipsychotics for Dementia
9. Some antipsychotic drugs may be missing their mark
10. Weight gain induced by antipsychotic drugs can be avoided
11. Drug-free treatments offer hope for older people in pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... NY (PRWEB) , ... May 24, 2017 , ... ... of dental implants in Bayside, NY, who have now spent 10 years as ... the New York University (NYU) College of Dentistry. Through the program, private practitioners ...
(Date:5/24/2017)... ... May 24, 2017 , ... Myers Jackson is well known for ... to sell luxury homes anywhere on the planet. The luxury home market is alive ... to Houston city-scapes. A quick search of “11 Spyglass Hill Auction will enlighten you ...
(Date:5/24/2017)... ... May 24, 2017 , ... Accordant Technology, a trusted IT ... delivers an analytics-first approach, layered with machine learning, that provides real-time visibility into ... the cloud to the edge. Through the new partnership, customers get the real-time ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... most prominent for-profit and nonprofit hospitals and health systems in the nation and ... around their institutions, led professional organizations and been instrumental in developing successful hospital ...
(Date:5/23/2017)... ... May 23, 2017 , ... MDLand International (MDLand), ... announced today that its iClinic V12.2 solution has achieved approval from National Center ... introduced PCMH 2017 standards which emphasize team-based care with a significant focus on ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... 2017 Enterin Inc., a privately-held CNS pharmaceutical company ... compounds to treat Parkinson,s disease (PD), has enrolled the first ... 1/2a randomized, controlled, multicenter study involving patients with PD and ... patients over a 9-to-12-month period. The first stage is open ... PD. Participating sites include Denver , ...
(Date:5/10/2017)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... quarter ended April 1, 2017 .   GAAP diluted ... to the prior year period as the sale of ... while non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue ... currency terms.  Excluding the effects of blood screening and ...
(Date:5/10/2017)... -- Radiology has become the number one diagnostic tool ... to the number one ranking as a result.  More ... as the most complete and reliable method for clinical ... pain an MRI may confirm a suspected herniated disc ... entirely different treatment protocols.  In these circumstances, patients need ...
Breaking Medicine Technology: