CHICAGO, IL. (May 28, 2010)There's debate about the best treatment approach for patients with certain stages of non-small cell lung cancer (NSCLC), which accounts for about 80 percent of all lung cancers. Patients with early stages of NSCLC are typically treated with surgery, but those with stage IIIA present more of a challenge because they are such a diverse group. However, research from Fox Chase Cancer Center shows that patient's with stage IIIA NSCLC who receive surgery, lobectomy in particular, have increased overall survival compared to those who received chemoradiation alonethose receiving lobectomy plus chemoradation had survival rates that were higher than previously reported as well.
The research, led by Charu Aggarwal, M.D., M.P.H., Walter Scott, M.D., F.A.C.S., and George Simon, M.D., will be presented at the 46th Annual Meeting of the American Society of Clinical Oncology on Sunday June 6.
Stage IIIA presents challenges because patients classified at that level are such a diverse group. The common denominator is that cancer has spread to lymph nodes on the same side of the chest as the primary tumor, but beyond that, stage IIIA patients may have tumors of any size and may differ in the number and location of affected lymph nodes.
"In the past, patients with advanced stage lung cancer were treated either with surgery alone, chemotherapy alone, or radiation alone," says Aggarwal. "Scientists and clinicians found that adding radiation to chemotherapy improved survival, so concurrent chemotherapy and radiation together became the standard of care." Recent large, Phase III clinical trials showed that patients treated with chemoradiation followed by surgery were more likely to be disease-free than counterparts who received chemoradiation without surgery set the stage for Aggarwal's study.
Looking at data from 249 patients treated at Fox Chase for stage IIIA non-small cell lung cancer from 2000 through 2008, the
|Contact: Diana Quattrone|
Fox Chase Cancer Center