Navigation Links
Comorbidities increase risk of mortality in COPD patients
Date:5/3/2012

Comorbidities are common among patients with chronic obstructive pulmonary disease (COPD), and a number of these comorbidities are independently associated with an increased mortality risk, according to a new study.

"We followed 1,664 COPD patients recruited from five pulmonary clinics in the United States and Spain for a median of 51 months," said lead author Miguel Divo, MD, a physician in the Pulmonary and Critical Division at Brigham and Women's Hospital and Instructor in Medicine at Harvard Medical School. "Among the 79 comorbidites we observed in these patients, 12 were significantly and independently associated with an increased risk of death."

The 12 comorbidities with the strongest association with an increased risk for death were lung cancer, pancreatic cancer, esophageal cancer, breast cancer, pulmonary fibrosis, atrial fibrillation/flutter, congestive heart failure, coronary artery disease, gastric/duodenal ulcers, liver cirrhosis, diabetes with neuropathy and anxiety.

"We used these 12 comorbidities to develop a new comorbidity risk index (the COPD specific CO-morbidity Test, or COTE)," Dr. Divo said. "After adjustment for age, gender, race, and BODE (Body Mass Index; FEV1; Dyspnea and Exercise capacity) index, an increased COTE index was a significant predictor of death in our cohort of COPD patients."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The average number of comorbidities per subject in the cohort overall was 6.0 (3.5), and the average number of comorbidities was significantly higher among non-survivors (6.5 3.8) compared with survivors (5.8 3.3).

"These easily identifiable comorbidities could be screened by health care providers caring for COPD patients, as there may be effective interventions that may help decrease the risk of death," Dr. Divo said.

The study had some limitations. The proportion of women included in the study (11 percent) was low. Some patients were excluded at baseline because of comorbidities that might cause early death, including a recent myocardial infarction, severe congestive heart failure, and untreated cancer. Finally, patients were recruited from specialty clinics, and so might not represent all COPD patients.

"In this study we have confirmed earlier observations that patients with COPD frequently suffer from comorbidities, and have shown that 12 specific comorbidities are associated with an increased mortality risk in these patients," Dr. Divo concluded. "The simple comorbidity risk index we developed based on these 12 comorbidities complements the BODE index and can be used to help predict an increased risk of death in COPD patients in both clinical and research settings."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. New evidence highlights risk of comorbidities for COPD patients
2. Email vacations decrease stress, increase concentration, researchers say
3. Regular jogging shows dramatic increase in life expectancy
4. Saliva test could dramatically increase detection of oral cancer
5. MP3 song-searching can increase risk for drivers
6. BASPCAN - UK-wide increase in number of children
7. Depression increases death risk in coronary stent patients
8. Cadmium in Diet May Increase Breast Cancer Risk
9. Children exposed to cigarette smoke have increased risk of COPD in adulthood
10. Leading infectious diseases experts call for increased focus on protecting antibiotics
11. Increased collaboration between nursing home RNs and LPNs could improve patient care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... , ... ARI Network Services, Inc. (NASDAQ: ARIS) announced today that Rhino Ag ... network of more than 650 U.S.-based dealers. Rhino, a member of the Alamo Group, ... mowers and cutters, rear blades, post hole diggers, pasture renovators, tillers, disc mowers and ...
(Date:3/29/2017)... ... March 29, 2017 , ... The Professional Squash Association, the ... New York City-based sports and entertainment marketing firm Leverage Agency as its exclusive ... the Professional Squash Association (PSA), which includes first-time ever title sponsorship, naming rights, ...
(Date:3/29/2017)... ... 30, 2017 , ... Grass pollen is the main cause of hay fever in the United ... for grass pollen runs from May to July each year; with the worst time for ... HayMax™ allergen barrier balms ( http://www.haymax.us ) provide an effective defense against grass pollen; they ...
(Date:3/29/2017)... ... ... Youth Futures International (YFI) premiered its Serve, Learn, & Empower program in ... who have participated in the program every summer. The 2017 Serve, Learn, & ... enrollment. Visit http://www.ghana.yfiexperience.org to learn more. , “I have sent my ...
(Date:3/29/2017)... , ... March 30, 2017 , ... Sports Brand EXOUS ... brace, which retails normally at $29.97; for the remaining days of March, the price ... been reduced to a special price of just $10 (regular retail price $19.97). , ...
Breaking Medicine News(10 mins):
(Date:3/30/2017)... 30, 2017  Lannett Company, Inc. (NYSE: ... a $25 million payment against its existing revolving credit ... with the $75 million payment we made earlier this ... in annualized cash interest expense, at current rates" said ... "Our business is solid and we continue to generate ...
(Date:3/30/2017)... Revenue Prospects by Product Type (Metered Dose Inhalers, Dry ... Respiratory Inhalers - our new study reveals trends, R&D progress, ... If you are involved in this sector you must read this ... revenues streams to 2027, assessing data, trends, opportunities and business prospects ... Discover how ...
(Date:3/30/2017)... , March 30, 2017  Purcell Julie & Lefkowitz LLP, ... is investigating a potential breach of fiduciary duty claim involving ... SGYP ). If you are a ... information regarding this investigation, free of charge, please visit us ... ...
Breaking Medicine Technology: