Navigation Links
Comorbidities increase risk of mortality in COPD patients

Comorbidities are common among patients with chronic obstructive pulmonary disease (COPD), and a number of these comorbidities are independently associated with an increased mortality risk, according to a new study.

"We followed 1,664 COPD patients recruited from five pulmonary clinics in the United States and Spain for a median of 51 months," said lead author Miguel Divo, MD, a physician in the Pulmonary and Critical Division at Brigham and Women's Hospital and Instructor in Medicine at Harvard Medical School. "Among the 79 comorbidites we observed in these patients, 12 were significantly and independently associated with an increased risk of death."

The 12 comorbidities with the strongest association with an increased risk for death were lung cancer, pancreatic cancer, esophageal cancer, breast cancer, pulmonary fibrosis, atrial fibrillation/flutter, congestive heart failure, coronary artery disease, gastric/duodenal ulcers, liver cirrhosis, diabetes with neuropathy and anxiety.

"We used these 12 comorbidities to develop a new comorbidity risk index (the COPD specific CO-morbidity Test, or COTE)," Dr. Divo said. "After adjustment for age, gender, race, and BODE (Body Mass Index; FEV1; Dyspnea and Exercise capacity) index, an increased COTE index was a significant predictor of death in our cohort of COPD patients."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The average number of comorbidities per subject in the cohort overall was 6.0 (3.5), and the average number of comorbidities was significantly higher among non-survivors (6.5 3.8) compared with survivors (5.8 3.3).

"These easily identifiable comorbidities could be screened by health care providers caring for COPD patients, as there may be effective interventions that may help decrease the risk of death," Dr. Divo said.

The study had some limitations. The proportion of women included in the study (11 percent) was low. Some patients were excluded at baseline because of comorbidities that might cause early death, including a recent myocardial infarction, severe congestive heart failure, and untreated cancer. Finally, patients were recruited from specialty clinics, and so might not represent all COPD patients.

"In this study we have confirmed earlier observations that patients with COPD frequently suffer from comorbidities, and have shown that 12 specific comorbidities are associated with an increased mortality risk in these patients," Dr. Divo concluded. "The simple comorbidity risk index we developed based on these 12 comorbidities complements the BODE index and can be used to help predict an increased risk of death in COPD patients in both clinical and research settings."


Contact: Nathaniel Dunford
American Thoracic Society

Related medicine news :

1. New evidence highlights risk of comorbidities for COPD patients
2. Email vacations decrease stress, increase concentration, researchers say
3. Regular jogging shows dramatic increase in life expectancy
4. Saliva test could dramatically increase detection of oral cancer
5. MP3 song-searching can increase risk for drivers
6. BASPCAN - UK-wide increase in number of children
7. Depression increases death risk in coronary stent patients
8. Cadmium in Diet May Increase Breast Cancer Risk
9. Children exposed to cigarette smoke have increased risk of COPD in adulthood
10. Leading infectious diseases experts call for increased focus on protecting antibiotics
11. Increased collaboration between nursing home RNs and LPNs could improve patient care
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: