Navigation Links
Communication pathways within proteins may yield new drug targets to stop superbugs
Date:1/31/2011

INDIANAPOLIS A School of Science at Indiana University-Purdue University Indianapolis biophysicist has developed a new method to identify communication pathways connecting distant regions within proteins.

With this tool, Andrew J. Rader, Ph.D., assistant professor of physics, has identified a mechanism for cooperative behavior within an entire molecule, a finding that suggests that in the future it may be possible to design drugs that target anywhere along the length of a molecule's communication pathway rather than only in a single location as they do today. The discovery holds promise for increasing the likelihood of therapeutic success.

The study, "Correlating Allostery with Rigidity" is published in the current issue of Molecular BioSystems, a journal of the Royal Society of Chemistry.

Microorganisms frequently contain enzymes, protein molecules that carry out most of the important functions of cells, not present in human cells. Blocking these enzymes can stop or kill a harmful invader.

Drugs are often developed to block or restrict the function of such enzymes, thereby treating the underlying infectious disease they convey. These drugs often target specific chemical sites on bacterial or viral enzymes, and alter the enzymes so they no longer function. Unfortunately, microorganisms can evolve enzymes that are impervious to these drugs, resulting in drug resistant organisms.

"With the growth of drug resistant organisms, it is increasingly important that we gain a better understanding of what makes enzymes within cellular proteins do what they do, so that we can develop alternative approaches to targeting these proteins, shutting down enzymes and killing these superbugs," said Rader, first author of the study.

He has found that the "poking" of one spot on the rigid pathway connecting regions within proteins produces communication along the entire pathway, indicating that drugs could be targ
'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University-Purdue University Indianapolis School of Science
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Close Relationships Sometimes Mask Poor Communication
2. ICU communication study reveals complexities of family decision-making
3. Parents of Bullies Urged to Open Lines of Communication
4. Bilingual benefits reach beyond communication
5. Wii-like technologies may help stroke survivors improve communication skills
6. Guided Care improves physician satisfaction with patient/family communications
7. Bacterial communication encourages chronic, resistant ear infections
8. Lexington Health Care Chooses OnShift for Nurse Scheduling and Employee Communications in all Facilities
9. Mayo Clinic Proceedings: Gabapentin opens window of communication
10. Online Housecalls, Improved Patient Care and Increased Communication Between Doctors and Healthcare Professionals Now Made Possible Through Docgreet.com
11. NTUs Wee Kim Wee School of Communication to host International Communication Association Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Communication pathways within proteins may yield new drug targets to stop superbugs
(Date:3/4/2015)... The Global Liquefied Petroleum Gas Market was ... estimated to grow to $288.7 billion by 2019, ... 2019. , Browse through the TOC of Global ... industry trends, segments & forecasts., http://www.micromarketmonitor.com/market-report/liquid-petroleum-gas-reports-5046983367.html ... is classified into source, application, and region. The ...
(Date:3/4/2015)... March 04, 2015 Organic Valley, the nation’s ... today announced its cause campaign to Save the Bros, ... is making a difference to Bros everywhere. To date, ... and Facebook. The video was named Adweek’s best commercial ... Forbes, Mashable and Digiday, among other media outlets. , ...
(Date:3/4/2015)... 2015 Columbus is no stranger to drug ... cocaine addiction, and suffers from the potential threat of ... 27th, the DEA revealed that Kratom is a “drug of ... the newly introduced herb from Southeast Asia acts as a ... WKYC notes kratom foments symptoms similar to heroin withdrawal, and ...
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 ... supports American military service members during and after their ... a Cause,” will increase awareness through advertising, social media ... funds for the patriotic organization through a special retail ... Sauvignon wines from March through May 2015. , ...
(Date:3/4/2015)... Port Richey, FL (PRWEB) March 04, 2015 ... Medical Detox cut the ribbon on their new facility in ... Pasco Chamber of Commerce. The new facility will allow the ... of helping end the prescription drug abuse epidemic through treatment ... current reality of drug addiction in the United States, we ...
Breaking Medicine News(10 mins):Health News:The Global Liquefied Petroleum Gas Market is Estimated to Reach $288.7 Billion by 2019 - A Report by MicroMarket Monitor 2Health News:The Global Liquefied Petroleum Gas Market is Estimated to Reach $288.7 Billion by 2019 - A Report by MicroMarket Monitor 3Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 3Health News:Columbus, OH Combats the Sale of Kratom as a Drug, Harbor Village Detox Stresses Caution 2Health News:Plungerhead Partners with the Boot Campaign to Benefit US Military Community 2Health News:Plungerhead Partners with the Boot Campaign to Benefit US Military Community 3Health News:Novus Medical Detox Hosts Ribbon Cutting Ceremony at Pasco County Facility 2Health News:Novus Medical Detox Hosts Ribbon Cutting Ceremony at Pasco County Facility 3
... A novel research finding from the investigators of Ohio ... of combination of metals like copper with organic chemicals ... range of diseases that are caused by virus.// ... of HIV and Hepatitis C virus RNA in the ...
... of middle-aged women and is characterized by recurring discomfort ... Symptoms vary and can include a combination of mild ... and pelvic area; and an urgent and/or frequent need ... become scarred or irritated, and pinpoint bleeding may appear ...
... HIV infection among its cadres, the Border Security Force ... outpost along West Bengal's international boundary. // ... launched in collaboration with the state AIDS control society ... troopers. ,"We are setting up these condom counters ...
... household activities like cleaning the house and the backyards, ... of prehypertension in people. // ,The study ... daily lifestyle physical activity had the effect of dropping ... hypertensive to prehypertensive and from prehypertensive to normal -- ...
... discriminate between self and non-self. If not for the ... would have lost its power to fight against diseases ... system produces certain substances called antibodies, which identify the ... "bad" so that other divisions of the immune system ...
... strong and science weak, men mistook magic for medicine; now, ... for magic. ~Thomas Szasz, The Second Sin, 1973 ... regarded as a forbidden organ too delicate to tamper with. ... World War II. Military doctors, facing injury and suffering on ...
Cached Medicine News:Health News:Metal In Medicines Can Fight Diseases Effectively 2Health News:Marijuana-Derived Drug Promises Hope In Treating Bladder Infection 2Health News:Free Condom Counters For Border Security Force Cadres 2Health News:Fighting against disease as easy as eating eggs 2Health News:Statins Taken For Reducing Cholesterol Found To Reduce Death Rate Associated With Heart Attack As Well 2
(Date:3/4/2015)... Mass. , March 4, 2015   HeartWare ... leading innovator of less invasive, miniaturized circulatory support technologies ... today announced that CEO Doug Godshall is ... Conference at 8:00 a.m. Eastern Time on Tuesday, March ... at the Loews Miami Beach Hotel in ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4f69k2/negative_pressure ) ... Pressure Wound Therapy Market (Conventional and Single Use ... Growth, Trends and Forecast 2014 - 2020" ... The global negative pressure wound therapy market is ... product types the NPWT market is segmented into ...
(Date:3/4/2015)... -- Sanomedics , Inc. (OTC: SIMH, SIMHD) ... that focuses on providing game changing products, services ... Thermomedics, Inc. , has appointed  Scott W. LeBel ... will be reporting to Ron Benincasa , ... responsible for supporting assigned distributor relationships with the ...
Breaking Medicine Technology:HeartWare Presentation At The 2015 Barclays Global Healthcare Conference To Be Webcast 2Global Negative Pressure Wound Therapy (Conventional and Single Use NPWT Systems) Market Report 2014-2020 2Sanomedics Hires Scott W. LeBel as Director of Specialty and Government Sales 2Sanomedics Hires Scott W. LeBel as Director of Specialty and Government Sales 3
... SILVER SPRING, Md., Nov. 30, 2011 The U.S. ... version of the cholesterol-lowering drug Lipitor (atorvastatin calcium tablets). ... Ranbaxy Laboratories Ltd. has gained approval to make generic ... mg, and 80 mg strengths. The drug will be ...
... PRINCETON, N.J., Nov. 30, 2011 IntegriChain, Inc., a ... by Forbes as #19 on the list of America,s ... services to help customers improve order forecasting, order monitoring, ... planning. IntegriChain has grown 60% over the past three ...
Cached Medicine Technology:FDA Approves First Generic Version of Cholesterol-Lowering Drug Lipitor 2FDA Approves First Generic Version of Cholesterol-Lowering Drug Lipitor 3Forbes Announces IntegriChain in Top 20 on List of America's Most Promising Companies 2
The IR 1000 Insulin Infusion Pump from Animas offers unprecedented safety features, performance, and convenience....
SPR treats pigmented and vascular lesions, skin aging, sun damaged skin and fine lines and wrinkles with clinically proven LHE technology....
Inquire...
Sebia's Hb AFSC Control provides excellent resolution of normal hemoglobins A & F and abnormal hemoglobins S & C. The control is designed for use with Sebia's Hydragel Hemoglobin and Hydragel Acid He...
Medicine Products: