Navigation Links
Commonly used ulcer drugs may offer treatment potential in Alzheimer's disease
Date:4/22/2009

Amsterdam, 22 April 2009 In a new study, published in the May issue of Elsevier's Experimental Neurology (www.elsevier.com/locate/yexnr), scientists at the University of British Columbia have discovered that drugs commonly used to treat ulcers have significant neuroprotective properties, which appear to be enhanced when used in combination with ibuprofen, a widely used anti-inflammatory drug.

"Our results show that proton pump inhibitors are also antiinflammatory agents. They open up an entirely new application for these drugs" said Dr. Sadayuki Hashioka, first author on the paper.

Proton pump inhibitors include lansoprazole and omeprazole. They are remarkably safe drugs which have so far been used only to treat ulcers and other conditions where there is excess gastric acidity. These include Helicobacter pylori infections and side effects from treatment with NSAIDs such as ibuprofen. The finding that they also have anti-inflammatory potential opens up the possibility of using these drugs in a variety of inflammatory conditions where NSAIDs are now used. There would be the double effect of protection from gastrointestinal side effects plus enhanced antiinflammatory activity.

The researchers found that when human microglia, or human monocytic THP-1 cells, were exposed in vitro to the proton pump inhibitors, their secretions became less toxic towards human neuroblastoma cells. In addition, they found that these drugs acted synergistically with ibuprofen, a very widely used antiinflammatory agent. To confirm that the proton pump inhibitors were acting to inhibit inflammation, they found that lansoprazole and omeprazole reduced the secretion from THP-1 cells of the inflammatory cytokine tumor necrosis factor alpha.

Dr. Patrick McGeer, senior investigator on the UBC team, commented "Many epidemiological studies have revealed that individuals on long term treatment with ibuprofen are relatively spared from Alzheimer disease. Our investigation indicates that individuals taking lansoprezole or omeprazole in addition to ibuprofen might be getting even greater protection. It also suggests that a clinical trial of a combination of ibuprofen and a proton pump inhibitor might be effective for those already suffering from Alzheimer disease".

Epidemiological studies might show a sparing effect of Alzheimer disease through the use of proton pump inhibitors alone".


'/>"/>

Contact: Jonathan Atkinson
j.atkinson@elsevier.com
44-186-584-3234
Elsevier
Source:Eurekalert

Related medicine news :

1. Drug commonly used for alcoholism, drug addiction, curbs urges of compulsive stealers
2. Commonly used beauty staple clinically proven to help treat eczema
3. Commonly Used Beauty Staple Clinically Proven to Help Treat Eczema
4. Risk of death may be higher with drug commonly used during cardiac surgery
5. LegalView Informs Patients of Possible Cimzia Cancer Link, Drug Commonly Used to Treat Arthritis
6. Allergic-like reactions to iodinated contrast material treated safely with commonly used medications
7. Incidental adrenal masses commonly seen on CT are usually benign; no follow-up needed
8. Melissa Biggs, Fashion Designer and Former Baywatch Actress, Teams with CSL Behring to Raise Awareness of Alpha-1 Antitrypsin Deficiency, a Commonly Misdiagnosed Respiratory Disease
9. Commonly used medications associated with impaired physical function in older adults
10. Cells on path to becoming mature T-cells more flexible than commonly thought
11. New U of C research examines commonly used toxin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... AvePoint , the Microsoft Cloud expert, ... in Richmond, Virginia, located at the Riverfront Plaza, 901 East Byrd Street. AvePoint is ... Virginia Ralph S. Northam and Mayor of Richmond Levar M. Stoney. , Founded in ...
(Date:3/28/2017)... ... March 28, 2017 , ... A recent Bellwether ... teacher quality, the field must first improve teacher preparation program design. It then ... next” and that decades of input- and outcome-based research has failed to improve ...
(Date:3/28/2017)... , ... March 28, 2017 , ... For many women, getting birth control isn’t as ... , meaning they either don’t have access to a health care facility or a pharmacy ... remote regions of the United States or for many who are faced with health or ...
(Date:3/28/2017)... and CARTERSVILLE, Georgia (PRWEB) , ... March 28, ... ... senior analyst to its award-winning team. Ruel Williamson brings his extensive knowledge of ... has been a leader in the real estate valuation industry for more than ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... representatives in state legislatures and Congress to protect parental rights and civil liberties, ... and safety in America. , The demonstration coincides with a press conference taking ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... DIEGO , March 29, 2017  NuVasive, ... focused on transforming spine surgery with minimally disruptive, ... Administration (FDA) 510(k) clearance of the CoRoent® Small ... multiple contiguous levels in the cervical spine. This ... cage to be used at up to four ...
(Date:3/29/2017)... HEIGHTS, Utah , March 29, 2017 /PRNewswire/ ... ) announced today the appointment of Cynthia ... Operations.  Cyndi will be responsible for leading Dynatronics ... organization and will report to Dynatronics, CEO ... Cyndi,s appointment concludes an extensive search process conducted ...
(Date:3/29/2017)... NetworkNewsWire Editorial Coverage  ... There are a number of advantages ... economic arguments also favor its legalization. The benefits include increased ... to legalize and regulate marijuana requires an ecosystem of support ... SING Profile ), American Cannabis Company (OTC: AMMJ), Kush Bottles, ...
Breaking Medicine Technology: