Navigation Links
Commonly used supplement may improve recovery from spinal cord injuries
Date:9/28/2011

LEXINGTON, Ky. -- A commonly used supplement is likely to improve outcomes and recovery for individuals who sustain a spinal cord injury (SCI), according to research conducted by University of Kentucky neuroscientists.

Sasha Rabchevsky, associate professor of physiology, Patrick Sullivan, associate professor of anatomy and neurobiology, and Samir Patel, senior research scientist -- all of the UK Spinal Cord and Brain Injury Research Center (SCoBIRC) -- have discovered that in experimental models, severe spinal cord injury can be treated effectively by administering the supplement acetyl-L-carnitine or ALC, a derivative of essential amino acids that can generate metabolic energy, soon after injury.

The researchers previously reported that following spinal cord injury, the mitochondria, or energy-generation components of cells, are overwhelmed by chemical stresses and lose the ability to produce energy in the form of the compound adenosine triphosphate (ATP). [1,2] This leads to cell death at the injury site and, ultimately, paralysis of the body below the injury level.

Rabchevsky, Sullivan and Patel have recently demonstrated that ALC can preserve the vitality of mitochondria by acting as an alternative biofuel providing energy to cells, thus bypassing damaged mitochondrial enzymes and promoting neuroprotection. [3]

Results soon to be published show that systemic administration of ALC soon after a paralyzing injury promoted the milestone recovery of the ability to walk. Unlike the animal control group given no ALC, which regained only slight hindlimb movements, the group treated with ALC recovered hindlimb movements more quickly and were able to stand on all four limbs and walk a month later. Critically, such remarkable recovery was correlated with significant tissue sparing at the injury site following administration of ALC.

Because ALC can be administered orally, and is well-tolerated at relatively high doses in humans, re
'/>"/>

Contact: Allison Elliott
allison.elliott@uky.edu
859-323-2394
University of Kentucky
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Commonly used defibrillators raise risk of problems
2. Study shows PRP, commonly used technique to improve healing, doesnt work in rotator cuff surgery
3. Soy-based natural S-equol supplements improve crows feet skin wrinkles in menopausal women
4. Study finds popular muscle-boosting supplement does not increase blood flow
5. Soy Supplements Dont Ease Bone Loss, Menopausal Symptoms: Study
6. Prenatal Omega-3 Fatty Acid Supplements May Cut Babies Colds
7. Supplement found to improve quality of life for female cancer survivors
8. Care for a spot of (green) tea? New NIST reference materials for popular diet supplement
9. Study Suggests Supplement May Protect Against Preeclampsia
10. Selenium Supplements Might Give Modest Benefit Against Cholesterol
11. Study Questions Giving Babies Botanical Supplements, Teas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... Studio B Dental in Toronto now offers All-on-Four dental ... a Day, gives patients the opportunity to replace their damaged ... whites with very little recovery time and no bone grafting. ... like natural teeth, and require no special care beyond the ... is one of the premiere dental experts on All-on-Four implants ...
(Date:7/26/2014)... 2014 According to the Metabolic Enhancement ... a comprehensive bodybuilding program that helps men lose body ... steroids . The program also instructs men how to ... , Vkool reveals in its review that this program ... help men get ripped and jacked at the same ...
(Date:7/26/2014)... 2014 The birth control safety center ... contraceptive of new legal information on the site. A ... number of lawsuits pending for July alleging side effects ... for those using popular prescription drugs and medical devices. ... and legal news all in one place, they can ...
(Date:7/25/2014)... Dallas, TX (PRWEB) July 26, 2014 ... China Laser Scanning Confocal Microscope Industry” is ... China Laser Scanning Confocal Microscope market. The ... information, including Laser Scanning Confocal Microscope definition, ... as industry overview. This research covers international market ...
(Date:7/25/2014)... A federal judge has denied defense ... Pinnacle hip lawsuits ( http://www.depuypinnacle-lawsuit.com/ ) selected as ... go before a jury on September 1, 2014, Bernstein ... 18th, U.S. District Judge Ed Kinkeade of the Northern ... may proceed to trial against Johnson & Johnson, the ...
Breaking Medicine News(10 mins):Health News:Studio B Dental Improves Patient Smiles with All-on-Four Dental Implants 2Health News:Metabolic Enhancement Training Review Exposes Scott Abel's Program for Bodybuilding – Vkool.com 2Health News:Metabolic Enhancement Training Review Exposes Scott Abel's Program for Bodybuilding – Vkool.com 3Health News:DrugNews Adds Latest Court Updates on Mirena IUD Lawsuits 2Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 2Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 3Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 4Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 2Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 4
... Panacea Biotech has bagged the registration, production and marketing rights ... in the Jawaharlal Nehru University (JNU). It is expected that ... The Company has made a milestone payment to JNU for ... a royalty on sales. However, the company is yet to ...
... 20 years, scientists have laboured under the assumption that ... form its structure and carry out its activities. However, ... influenza virus protein.This protein may kill immune system cells ... potency, the researchers say.// ,The scientists turned up ...
... sucking in children should be stopped in order to prevent problems ... or use a pacifier after the age of 2 may be ... time they reach adolescence, a team of dentists reports.,Their study found ... thumb by the age of 4 to 5 were more likely ...
... to researchers the appropriate treatment should be recommended for ... complications. Women who have// had breast cancer do well ... tamoxifen may have reduced physical functioning. Researchers at the ... studies looking at quality of life in long-term survivors ...
... study a diet high in animal products raises the ... protection. Many studies have suggested a link between a ... cancer.// An independent researcher based in Chicago, USA, reveals ... breast cancer. Rates are high where the proportion of ...
... suggested that immunisation can protect against cot deaths in ... of death in children over one month old,//even though ... reduced the numbers of deaths. ,Scientists from ... cases from between 1984 and 1994, checking to see ...
Cached Medicine News:
(Date:7/24/2014)... and MARSEILLE, France , July 24, ... global license from University of Tokyo enables development of ... gene panels, for blood cancers  Mutations of ... favorable prognosis for patients with bone marrow disorders known ... developing companion diagnostics to guide treatment with new anti-cancer ...
(Date:7/24/2014)... 2014  IRIDEX Corporation (NASDAQ: IRIX ) ... 2014 financial results after the market closes on ... release, the Company will host a conference call with ... on Thursday, July 31, 2014 to ... developments. Interested parties may access the live ...
(Date:7/24/2014)... 24, 2014  IGI Laboratories, Inc. (NYSE MKT: IG), a ... announced its financial results for the second quarter ended June ... , Total revenues of $6.5 million in the second quarter ... in 2013 , Total revenues of $13.3 million for ... 78% over the same period in 2013 , Total ...
Breaking Medicine Technology:QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 2QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 3QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 4QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 5IGI Laboratories Announces Second Quarter 2014 Results 2IGI Laboratories Announces Second Quarter 2014 Results 3IGI Laboratories Announces Second Quarter 2014 Results 4IGI Laboratories Announces Second Quarter 2014 Results 5IGI Laboratories Announces Second Quarter 2014 Results 6IGI Laboratories Announces Second Quarter 2014 Results 7
... Sept. 12, 2011 The National Association of ... that facilitates cooperation between law enforcement, healthcare professionals, ... prevention and investigation of drug diversion – today ... survey by the Substance Abuse and Mental Health ...
... HAYWARD, Calif., Sept. 12, 2011 Intarcia Therapeutics, ... abstracts on ITCA 650 (DUROS® subcutaneous continuous delivery ... diabetes at the 47th Annual Meeting of the ... Lisbon, Portugal.  All three presentations are scheduled for ...
Cached Medicine Technology:Intarcia Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes 2Intarcia Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes 3Intarcia Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes 4
Inquire...
... work area that will help protect your ... irradiate the work area prior to use, ... be amplified. Containment features reduce the chance ... acrylic windows for a clear view, an ...
... x 24in(h). Designed to protect against ... The PCR Workstation irradiates the workspace prior ... airborne contamination by limiting exposure of experimental ... two fluorescent lights, one UV light, 12 ...
... Electropolished stainless steel ... mounts dampen vibration to ... as isolating vibration-producing equipment ... low-profile design allows for ...
Medicine Products: