Navigation Links
Commonly used medications associated with impaired physical function in older adults
Date:5/3/2008

WINSTON-SALEM, N.C. Older adults who take drugs designed to block the neurotransmitter acetylcholine including common medications for incontinence, high blood pressure and allergies are more likely to be dependent in one or more activities of daily living and to walk slower, according to new findings from researchers at Wake Forest University School of Medicine and colleagues.

The findings, which involve a class of drugs known as anticholinergic medications, are from the Ginkgo Evaluation of Memory Study (GEMS) and will be presented at the American Geriatrics Society Meeting in Washington, D.C., on May 3.

These results were true even in older adults who have normal memory and thinking abilities, said Kaycee M. Sink, M.D., M.A.S., lead author. For older adults taking a moderately anticholinergic medication, or two or more mildly anticholinergic medications, their function was similar to that of someone three to four years older.

In a separate study reported this month in the Journal of the American Geriatrics Society, Sink found that older nursing home residents who took medications for dementia and anticholingeric medications for incontinence at the same time had a 50 percent faster decline in function than those who were being treated only for dementia.

Over a years time, the decline would represent a resident going from requiring only limited assistance in an activity to being completely dependent, or from requiring only supervision to requiring extensive assistance in an activity.

Sink said that the two studies together suggest that physicians should carefully consider the implications when prescribing anticholingeric medications to older adults.

Because these medications are so commonly prescribed, older adults who take multiple medications are at increased risk of taking one or more anticholinergic-containing medications, said Sink. The potential effects on physical function represent a significant public health problem.

Many medications have anticholinergic properties including some for high blood pressure, some antidepressants, most allergy medicines and incontinence medicines. Some of the most common anticholinergics in the GEMS participants include the blood pressure medication nifedipine (Adalat or Procardia), which has mild anticholinergic properties, the stomach antacid ranitidine (Zantac), which has moderate anticholinergic properties, and the incontinence medication tolterodine (Detrol), which is highly anticholinergic.

In the GEMS study, the researchers sought to determine the effects of taking multiple anticholinergic drugs on walking speed and the ability to independently perform activities of daily living such as dressing, personal hygiene, toileting, transferring, bed mobility and eating as well as higher order activities including shopping, cooking, managing money, doing light housework and using a telephone.

The findings are from more than 3,000 people with an average age of 78 years. Almost half (40 percent) of participants were taking more than one anticholinergic drug. The researchers found that higher anticholinergic burden is associated with worse physical function, both self-reported and performance-based.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Phase III Trial of VELCADE(R) (Bortezomib) for Injection Showed Dramatic Fourfold Increase in Complete Remission Rates When Combined With the Most Commonly Used U.S. Regimen in Front-Line Multiple Myeloma
2. New U of C research examines commonly used toxin
3. Cells on path to becoming mature T-cells more flexible than commonly thought
4. AHRQ and FDA to Collaborate in Largest Study Ever of Possible Heart Risks with ADHD Medications
5. Diet and medications may assist prevention of prostate cancer
6. Cautious Optimism for New Alzheimers Medications, Reports the Harvard Mental Health Letter
7. Patients cant recall their medications to tell doctors
8. The American Pharmacists Association Supports Consumer Education About OTC Medications
9. Combining Medications Often Best Strategy to Battle Rheumatoid Arthritis
10. Many Osteoporosis Medications Prevent Fractures, But None Is Proven Best
11. Cost of glaucoma medications may impact treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... HMP , ... recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ ... on October 11, 2017. , The annual award competition recognizes editorial and design excellence ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical ... to physician colleagues, skilled nursing facility medical directors and other clinicians at various ... Wound Care." , "At many of these conferences we get to educate other ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)...   ZirMed Inc ., a recognized leader in cloud-based ... has been ranked #1 by its users for the seventh ... User Survey. ZirMed was recognized as the top-ranked end-to-end revenue ... centers over 200 beds and holds one of the longest ... history. ...
(Date:9/12/2017)... reviews on the independent review site Consumer Affairs have ... hearing aids, ranking it higher than Miracle Ear ™, Beltone™, ... ... Aids ... that provides high performance, state-of-the-art, German-engineered hearing aids directly to consumers ...
Breaking Medicine Technology: