Navigation Links
Commonly used drug can limit radiation damage to lungs and heart for cancer patients
Date:4/21/2013

art soon after irradiation. So these new findings show that ACE inhibition decreases RILT by reducing direct acute heart damage."

Irradiating the heart leads to the development of fibrosis, which stiffens it, and this in turn leads to problems in the relaxation of the left ventricle. Due to this, blood flow from the lungs into the heart is hindered, and this can cause pulmonary damage. However, after treatment with captopril, the researchers observed an improvement in ventricular relaxation in the irradiated hearts.

Dr Van der Veen and her colleagues are now collaborating with a research group from the Mayo Clinic, Rochester, Minnesota (USA), in order to design a randomised clinical trial where patients who are treated with radiation to the thoracic area including the heart will be treated with either an ACE inhibitor or a placebo after irradiation.

Much progress has been made in radiation treatment over recent years, but in breast cancer, for example, most women still receive high doses to the heart, and this is known to increase the risk of heart disease. A recent study [3] has shown that for each Gray (Gy) [4] of radiation, there is a 7.4% increase in the occurrence of a subsequent major coronary event.

"Given that most women will receive a dose of between 1 and 5 Gray, and that the dangers are even greater for women with existing cardiac risk factors or coronary disease, this is still a big problem," said Dr Van der Veen.

Rats were chosen for the study because, unlike mice, they are big enough for researchers to be able to irradiate different part of the lungs and heart. The researchers believe that the way in which ACE inhibition works in both animals and humans is similar.

"We are confident that our clinical trial will see the same protective effect in humans as that which we have seen in rats," said Dr Van der Veen. "We will also now begin to study the late effects of ACE inhibition on RILT to see whe
'/>"/>

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Commonly used cholesterol calculation underestimates heart disease danger for many
2. UV Flash Infection Control Unit Steps onto the Healthcare Market, with a Quick and Effective Way to Disinfect Virtually any Item Commonly Found in Medical Facilities
3. New UAlberta research shows commonly prescribed medications could have adverse effects
4. Condition Commonly Seen in Aging May Alter Brain Function
5. Commonly used painkillers may protect against skin cancer
6. Memory, the adolescent brain and lying: The limits of neuroscientific evidence in the law
7. Career Confidential Announces Their Cover Letter Podcast Viewing Complimentary for a Limited Time
8. Asia-Pacific Seasonal Influenza Vaccine Market to 2018 - Positive Impact of Government Support Offset by Limited Production Capacity : MarketResearchReports.biz
9. Ability to think about thinking not limited to humans
10. iPad Ultra Thin Aluminum Bluetooth Keyboard Case Released by iGearUnlimited
11. Kwiksure Discovers Uses and Limitations of Vehicle GPS in Hong Kong
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... Loma Linda University Health announced today, ... being, it will be offering new, healthier choices in ... Over the past year, a cross-section of Loma Linda ... criteria, listening to vendors, sampling their products, and ultimately ... , Most recently, a food fair was held during ...
(Date:3/3/2015)... 03, 2015 The biggest name in ... reveal the world’s first fully integrated air quality platform ... controls an air purifier to remove dust, pollen and ... in control, via phone, tablet or computer. , Sweden’s ... 50 countries worldwide, will unveil its Internet-enabled air sensor ...
(Date:3/3/2015)... 03, 2015 The human augmentation market ... augmentation market. The wearable augmentation sector is predicted to ... in the upcoming years. , The eye-wear sector ... a big number of new products launches in the ... high technological advancements as well as the rising demand ...
(Date:3/3/2015)... NY (PRWEB) March 03, 2015 Daylight Savings ... spring. Sanjeev Kothare, MD, has tips for parents. , Parents ... March 8 at 2:00 a.m. when they set their clocks ... you wake up that day -- one hour earlier -- ... That’s why parents should start thinking about “sleep hygiene” for ...
(Date:3/3/2015)... 03, 2015 Sunday, March 1, through Saturday, ... the time of year, every region of the country is ... why Amica Insurance is sharing the following tips ... to help keep you safe in the event of severe ... Change wet clothing frequently to prevent loss of body heat. ...
Breaking Medicine News(10 mins):Health News:Loma Linda University Health Rejuvenates Its Vending Machines with Healthier Selections 2Health News:Smart sensor and air purifier interconnect to track and trap dust, pollen and dangerous particles in home and workplace air 2Health News:Human Augmentation Market to Pose 43.5% CAGR Through 2020, States MarketsandMarkets in its New Research Study Now Available at MarketPublishers.com 2Health News:Don’t Let Daylight Savings Disrupt Your Child’s Sleep 2Health News:Amica Insurance Has Tips for National Severe Weather Preparedness Week 2
... in the last financial year is to be announced by ... //feel that they would try to convince that what seems ... to a small number of NHS organisations and that the ... ,But they warn that these financial shortfalls re a ...
... who don’t play soccer or other contact sports may ... to the study this could explain why scenes of ... study attributes them to feelings of inadequacy. ... from the 18-to-21 age range hailing from different socioeconomic ...
... Namibia’s health ministry reports seven died of polio attack. ... case where the polio virus 1 of Wild Type was ... lab in South Africa reveals. ,Dr Kalumbi Shangula ... be immunized because about 34 people were admitted to hospitals ...
... V S Gaitonde and Jehangir Sabavala displayed their work ... paintings and sculptures held at Durban for a period ... having a cultural co-operation between Indian and South African ... like Iziko South African National Gallery (Iziko Sang) and ...
... hospitals is all set to open its 100-bed super-specialty hospital ... report in the Times of Oman newspaper quoted Apollo Medical ... hospital would become the first of its kind in the ... to fill the gap between super-specialty hospitals and polyclinics in ...
... Environmental agencies in Tamil Nadu are demanding monitoring stations ... samples //from the state among the most polluted in ... Pollution Control Board to apply for central funds to ... monitoring stations in Manali, Mettur, Cuddalore, Tuticorin and other ...
Cached Medicine News:Health News:UK Government Plans On Tackling Health Service Deficits 2Health News:Soccer Fans Seek Comfort From Alcohol 2Health News:Air Pollution in Tamil Nadu is a Cause of Concern for Environmentalists 2
(Date:3/3/2015)... ATLANTA , March 3, 2015  American ... owned, custom medical cable manufacturer actively engaged in ... interconnect technologies for the world,s leading medical device ... a high precision, low volume custom medical cable ... will retain the MTI brand under the name ...
(Date:3/3/2015)... Mass. , March 3, 2015  Web ... and manufacturing services in the Medical Device, Advanced ... has been named a 3M Medical Specialties Preferred ... new status will allow companies to streamline their ... point of contact for 3M materials, intermediate converting ...
(Date:3/3/2015)... Registration is officially open for MEDTEC China South ... the Shenzhen Convention & Exhibition Center. The Shenzhen ... join the MEDTEC China family of events. MEDTEC China South, ... better serve the South China market ... important region for China,s medical device ...
Breaking Medicine Technology:American Biosurgical Acquires MTI Corporation 2Web Industries Receives 3M Preferred Converter Status 2Pre-registration Open for 2015 MEDTEC China South 2Pre-registration Open for 2015 MEDTEC China South 3
... Senesco Technologies, Inc. ("Senesco" or the "Company") (NYSE Amex: ... survival studies that were conducted in Dr. William Scheld,s lab at ... treated with an siRNA against Senesco,s Factor 5A gene had a ... mice that received no treatment or a control siRNA.A total of ...
... speculation over what course the Swine Flu epidemic will ... ) last week analyzed the most recent peptide ... of the H1N1 virus will increase markedly, while its ... company,s quantitative analysis of the most recent sequence data ...
Cached Medicine Technology:Senesco Announces H1N1 Influenza Survival Test Results in Mice 2Senesco Announces H1N1 Influenza Survival Test Results in Mice 3Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: