Navigation Links
Commonly used 3-drug regimen for idiopathic pulmonary fibrosis found harmful
Date:10/21/2011

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a three arm multi-center, clinical trial studying treatments for the lung-scarring disease idiopathic pulmonary fibrosis (IPF) for safety concerns. The trial found that people with IPF receiving a currently used triple-drug therapy consisting of prednisone, azathioprine, and N-acetylcysteine (NAC) had worse outcomes than those who received placebos, or inactive substances.

"These findings underscore why treatments must be evaluated in a rigorous manner," said Susan B. Shurin, M.D., acting director of the NHLBI. "This combination therapy is widely used in patients with IPF, but has not previously been studied in direct comparison to a placebo for all three drugs."

The interim results from this study showed that compared to placebo, those assigned to triple therapy had greater mortality (11 percent versus 1 percent), more hospitalizations (29 percent versus 8 percent), and more serious adverse events (31 percent versus 9 percent) and also had no difference in lung function test changes. Participants randomly assigned to the triple- therapy arm also remained on their assigned treatment at a much lower rate (78 percent adherence versus 98 percent adherence).

"Anyone on some combination of these medications with questions or concerns should consult with their health care provider and not simply stop taking the drugs," said Ganesh Raghu, M.D., professor of medicine at the University of Washington, Seattle and a co-chair of this IPF study. "It is important to realize that these results definitively apply only to patients with well-defined IPF and not to people taking a combination of these drugs for other lung diseases or conditions."

The other two study arms, or intervention groups, of this IPF trial comparing NAC alone to placebo alone will continue. In stopping this part of the trial, the NHLBI accepted the
'/>"/>

Contact: NHLBI Communications Office
nhlbi_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Commonly used supplement may improve recovery from spinal cord injuries
2. Commonly used defibrillators raise risk of problems
3. Study shows PRP, commonly used technique to improve healing, doesnt work in rotator cuff surgery
4. Hepatitis C patients likely to falter in adherence to treatment regimen over time, Penn study shows
5. Integrating medication regimens into daily routines can improve adherence
6. Best post-transplant drug regimen identified for patients with new kidneys
7. Asian lung cancer patient survival exceeds Caucasians on multiple regimens
8. Early success of anti-HIV preventive oral drug regimen is promising, but questions remain
9. 6-month drug regimen cuts HIV risk for breastfeeding infants, NIH study finds
10. Bleeding Risk With Plavix-Aspirin Regimen May Be Serious
11. Studies Tout Alternative HIV Regimens for Women, Babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 25, 2014 Each year trauma accounts ... million hospital admissions across the nation (according to ... CDC’s National Hospital Ambulatory Medical Care Survey ... conducted in 2010. They estimated that there were between ... in a primary diagnosis of broken bone or fracture. ...
(Date:12/24/2014)... (PRWEB) December 25, 2014 Over 700 ... to their local communities. That is 700 smiling little ... single gift. Additionally over $6000 in monetary donations was ... offset some of the expenses they incur through the ... drive were A Child's Haven , Shrine's Children's ...
(Date:12/24/2014)... 2014 Recently, iFitDress.com, a famous dress manufacturer ... dresses under $150 . All these items are brand new; ... has already been updated with the new range of high ... so far. All iFitDress.com’s designs are made according to the ... great materials. Every outfit from the company is handpicked by ...
(Date:12/24/2014)... Dr. Vu Ho, a Dallas based facial plastic ... med-spa with the addition of new Silk Peel skin ... and services. , “Silk Peel is a procedure that ... “As a result it can address issues like acne ... or blemishes.” , Similar to microdermabrasion, Silk Peel ...
(Date:12/24/2014)... 25, 2014 Today, Yunx.co.uk, a hot ... dresses and other special occasion outfits, unveils 65 ... are offered at discounted prices, up to 80% off. ... ladies with their fashionable designs, gorgeous looks and delicate ... The business is devoted to designing and offering high-quality ...
Breaking Medicine News(10 mins):Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2
... speakers from across the United States and abroad ... and Responsibility for the 21st Century, an interdisciplinary ... University of Delaware,s Clayton Hall Conference Center in ... business, the ethical basis of carbon trading, responsible ...
... by father,s concern for son with debilitating condition , , THURSDAY, ... son led to research that now sheds new light on ... Andrew Chia, now 24, was diagnosed with debilitating chronic fatigue ... his father, Dr. John Chia, of a study which links ...
... of Maine now offers a complete, natural, effective, ... and now floss , KENNEBUNK, Maine, Sept. ... personal care products and values-based business, reaffirms its,commitment ... its natural,antiplaque dental floss has earned the American ...
... Nationwide Effort Encourages Parents to Pack Assorted Colors ... As part of the new Fruits &,Veggies-More Matters(TM) ... fruits and vegetables in their diets,September has become ... call-to- action, Welch,s has declared September 24-28, 2007,P.A.C.K. ...
... Efficiency in Medical Device Manufacturing, explores industry ... operational excellence, ATLANTA, Sept. 13 Visiprise, ... the integrated enterprise,announced today that the company will ... in the medical device industry. Titled "Operational,Efficiency in ...
... Caribbean Hospital Becomes Latest SafeTrace Tx(R) User, ... Bulletin Board: GLOB) today announced that its Wyndgate,Technologies(R) ... to the,Cardiovascular Center of Puerto Rico and the ... the agreement were not disclosed. (Logo: ...
Cached Medicine News:Health News:Environment, Energy and Ethics conference at UD, Sept. 21-23 2Health News:Stomach Virus a Culprit in Chronic Fatigue Syndrome 2Health News:Stomach Virus a Culprit in Chronic Fatigue Syndrome 3Health News:Tom's of Maine Tooth Floss Earns American Dental Association's Seal of Acceptance 2Health News:P.A.C.K. Week Declared in Support of Fruits & Veggies-More Matters Month 2Health News:P.A.C.K. Week Declared in Support of Fruits & Veggies-More Matters Month 3Health News:Visiprise Launches Podcast Series with AMR to Support Medical Device Manufacturers 2Health News:Global Med Technologies(R) Extends Its Worldwide Outreach 2Health News:Global Med Technologies(R) Extends Its Worldwide Outreach 3
(Date:12/24/2014)... 24, 2014 Kinex Pharmaceuticals announced today that ... Roswell Park Cancer Institute. KX2-361 (KX02), a ... has shown potent inhibitory activity against a broad panel ... resistant to Temozolomide (T98G), the most widely used chemotherapy ... brain tumor mouse model, KX2-361 consistently clears brain tumors ...
(Date:12/24/2014)... FLINT, Mich. , Dec. 24, 2014  Diplomat ... largest independent specialty pharmacy, is proud to announce ... and quality at Diplomat, will take office as the ... 2015. The formal induction ceremony will take place Feb. ... which will be held at the Renaissance Center in ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... 7, 2011 Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ... will present a company overview at Roth,s 23rd Annual OC ... p.m. PT at the Ritz Carlton Laguna Niguel.   ... available on the "Investors & Media" section of the Company,s ...
... Mass., March 7, 2011 Boston Scientific Corporation ... has received CE Mark for its OMEGA™ Platinum ... coronary stenting technology.  It incorporates Boston Scientific,s unique ... stenting and is intended to provide interventional cardiologists ...
Cached Medicine Technology:Boston Scientific Announces European Approval and Launch of OMEGA™ Platinum Chromium Stent System 2Boston Scientific Announces European Approval and Launch of OMEGA™ Platinum Chromium Stent System 3Boston Scientific Announces European Approval and Launch of OMEGA™ Platinum Chromium Stent System 4
Inquire...
... Hybridization Oven / Shaker : Temperature ... platform for the hybridization and incubation of ... be used for gel processing and staining. ... volumes to be used providing enhanced sensitivity ...
... (slot format) microfiltration units provide a reproducible ... in solution onto nitrocellulose or Zeta-Probe membrane. ... using interchangeable templates to form the 96-well ... SF apparatus. Each is available as a ...
... Small size is ideal for staining westerns ... used for multipurposes. Pour spouts in each ... or label may be used for identification. ... rockers or shakers for staining several gels ...
Medicine Products: