Navigation Links
Commonly used 3-drug regimen for idiopathic pulmonary fibrosis found harmful
Date:10/21/2011

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a three arm multi-center, clinical trial studying treatments for the lung-scarring disease idiopathic pulmonary fibrosis (IPF) for safety concerns. The trial found that people with IPF receiving a currently used triple-drug therapy consisting of prednisone, azathioprine, and N-acetylcysteine (NAC) had worse outcomes than those who received placebos, or inactive substances.

"These findings underscore why treatments must be evaluated in a rigorous manner," said Susan B. Shurin, M.D., acting director of the NHLBI. "This combination therapy is widely used in patients with IPF, but has not previously been studied in direct comparison to a placebo for all three drugs."

The interim results from this study showed that compared to placebo, those assigned to triple therapy had greater mortality (11 percent versus 1 percent), more hospitalizations (29 percent versus 8 percent), and more serious adverse events (31 percent versus 9 percent) and also had no difference in lung function test changes. Participants randomly assigned to the triple- therapy arm also remained on their assigned treatment at a much lower rate (78 percent adherence versus 98 percent adherence).

"Anyone on some combination of these medications with questions or concerns should consult with their health care provider and not simply stop taking the drugs," said Ganesh Raghu, M.D., professor of medicine at the University of Washington, Seattle and a co-chair of this IPF study. "It is important to realize that these results definitively apply only to patients with well-defined IPF and not to people taking a combination of these drugs for other lung diseases or conditions."

The other two study arms, or intervention groups, of this IPF trial comparing NAC alone to placebo alone will continue. In stopping this part of the trial, the NHLBI accepted the
'/>"/>

Contact: NHLBI Communications Office
nhlbi_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Commonly used supplement may improve recovery from spinal cord injuries
2. Commonly used defibrillators raise risk of problems
3. Study shows PRP, commonly used technique to improve healing, doesnt work in rotator cuff surgery
4. Hepatitis C patients likely to falter in adherence to treatment regimen over time, Penn study shows
5. Integrating medication regimens into daily routines can improve adherence
6. Best post-transplant drug regimen identified for patients with new kidneys
7. Asian lung cancer patient survival exceeds Caucasians on multiple regimens
8. Early success of anti-HIV preventive oral drug regimen is promising, but questions remain
9. 6-month drug regimen cuts HIV risk for breastfeeding infants, NIH study finds
10. Bleeding Risk With Plavix-Aspirin Regimen May Be Serious
11. Studies Tout Alternative HIV Regimens for Women, Babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... 2015 As the nation recognizes the ... sacrifices of these young men and women, the “Alaska ... and their Families” presents a special training session on ... gain a better understanding of the effect of childhood ... those – civilian and military – who provide services ...
(Date:4/24/2015)... 24, 2015 The 1975 have ... constantly across the globe to theaters, festivals and TV performances. ... they’ve partnered with their label, Dirty Hit Records, to provide ... with the newly launched Cadence & Cause website, ... LP on vinyl and a signed photo card. Entries ...
(Date:4/24/2015)... 24, 2015 Anchor Health Administrators (Anchor), ... Professionals, today announced their exclusive agreement with LTC Solutions ... Care Insurance distribution partner. , Anchor has more than ... Insurance benefits for associations, and is currently the designated ... Long Term Care Insurance member benefit. , “I am ...
(Date:4/24/2015)... 24, 2015 Insuranceautoquote.info has released a ... insurance premiums . , Lowering auto insurance prices ... to simply find better offers for their financial budget. ... it does not require any registration. , Comparing ... There are multiple agencies that sell coverage and this ...
(Date:4/24/2015)... 24, 2015 Telematics Berlin is the ... tier 1 & 2 suppliers, content providers, associations and ... in the value chain, see them converge in Berlin. ... only hear from those companies currently at the forefront ... partners. Working on customer centric products, ParkTAG are one ...
Breaking Medicine News(10 mins):Health News:Coalition Presents Resiliency Training to Raise Awareness during Month of the Military Child (#MOTMC2015) 2Health News:Internationally Recognized British Indie Rock Outfit The 1975 Partner with Cadence & Cause to Provide Clean Drinking Water to Those in Need 2Health News:Car Insurance Quotes Can Help Drivers Lower Their Premiums 2Health News:Telematics Berlin 2015’s inaugural European Automotive Start-Up Competition 2Health News:Telematics Berlin 2015’s inaugural European Automotive Start-Up Competition 3
... Cardium Therapeutics,(NYSE Alternext: CXM) and its operating ... adoption of procedures designed to promote,temperature modulation therapy ... in The New York Times . ... 2008, reports that New York City ambulances will ...
... today,announced that its employees committed more than $1 million ... This amount is the,result of personal giving by associates ... , "In this ... in need of help," said Mark Wagar, president and,CEO ...
... Seniors, Access to Quality Care, LTC Jobs Base , ... Commenting on the legislative year ahead as well as the ... nursing facilities (SNFs) should not receive a market basket cost ... term care advocacy organizations today said the sector supports and ...
... controls for intravenous use, standardization of practices , , FRIDAY, ... their own pain medication intravenously is four times more ... a new study says. , The report, ... Commission Journal on Quality and Patient Safety , shows ...
... Systems (NYSE: VAR ) announced today that its Board ... for February 12, 2009 with a record date of December 15, ... 4290 El Camino Real, Palo Alto, California at 4:30 p.m. PT. ... webcast by Thomson Financial and can be accessed at Varian Medical ...
... LLC, creator,of the Sensible Portions brand, is teaming with the ... the IZOD CENTER. , ... Nets are recognizing the,need to provide fans with healthier in-game ... Crisps, which are,baked, all natural, and contain no trans fat, ...
Cached Medicine News:Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 2Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 3Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 4Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 5Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 6Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 7Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 8Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 9Health News:Empire BlueCross BlueShield Associates Commit Over $1 Million to Community Organizations in 2008 2Health News:Long Term Care Sector Supports and Is Well-Positioned to Advance Health Care Reform, Bolster Economic Stimulus 2Health News:Long Term Care Sector Supports and Is Well-Positioned to Advance Health Care Reform, Bolster Economic Stimulus 3Health News:Self-Dosing Pain Medication Errors Too Common: Study 2Health News:Varian Medical Systems Schedules Annual Stockholder Meeting in Palo Alto 2Health News:Nets Provide Fans with Healthy In-Game Snack Option 2
(Date:4/24/2015)... , April 24, 2015 Allowing more ... could reduce drug overdose deaths that involve opioids, according ... study, "Disparity in Naloxone Administration by Emergency Medical Service ... Communities," published in the American Journal of Public ... deaths in the United States ...
(Date:4/24/2015)...  IGI Laboratories, Inc. (NYSE MKT: IG), a ... company, announced the Company will hold a conference call ... to discuss the 1st quarter 2015 results. ... by dialing 1-888-346-3479. International participants should call 1-412-902-4260. Canadian ... joined into the IGI Laboratories, Inc. call. ...
(Date:4/24/2015)... , April 24, 2015   Vestagen Technical ... technology, VESTEX ® , has recently received two notable ... a global competition that recognizes innovations with potential to ... ceremony last night in New York City ... the Material Science "Protection & Safety" category. The awards ...
Breaking Medicine Technology:Expanding Naloxone use could reduce drug overdose deaths and save lives 2Expanding Naloxone use could reduce drug overdose deaths and save lives 3VESTEX Wins Innovation Honors from Edison Awards & Apparel Magazine 2VESTEX Wins Innovation Honors from Edison Awards & Apparel Magazine 3
... cassettes, 4 fiber pads, modular electrode assembly, ... with cables, and instructions. The Mini ... mini electrophoresis system (see Mini-Vertical Electrophoresis Systems), ... Its modular electrode assembly transfers two 7.5 ...
... PowerPac 200 power supply. ... Parameters. Quantitative Transfers. Native ... Transfers. Faster, Higher-Efficiency Transfers ... Field-Intensity Transfers with Movable Electrodes. ...
... holder cassettes, cell with lid ... blot absorbent paper (15 x ... cell, used with the PowerPac ... high-intensity electrophoretic transfers. The Trans-Blot ...
... running Criterion precast gels and Criterion ... fit for use with the incredible ... Criterion blotter combines excellent blotting efficiency ... system and the ease-of-use of the ...
Medicine Products: