Navigation Links
Commonly-prescribed drugs may influence the onset and progression of Alzheimer's disease
Date:6/12/2013

Multiple drug classes commonly prescribed for common medical conditions are capable of influencing the onset and progression of Alzheimer's disease, according to researchers at The Mount Sinai Medical Center. The findings are published online in the journal PLoS One.

Led by Giulio Maria Pasinetti, MD, PhD, the Saunders Family Chair and Professor in Neurology at Mount Sinai, a research team used a computer algorithm to screen 1,600 commercially-available medications to assess their impact on the brain accumulation of beta-amyloid, a protein abnormally accumulated in the brain of Alzheimer's disease and implicated in neurodegeneration. They found that currently-available medications prescribed for conditions such as hypertension, depression, and insomnia were found to either to block or to enhance the accumulation of beta-amyloid, the component of amyloid plaques.

"This line of investigation will soon lead to the identification of common medications that might potentially trigger conditions associated with the prevention, or conversely the onset, of Alzheimer's disease," said Dr. Pasinetti. "They may be a novel reference for physicians to consider when prescribing the most appropriate drug, particularly in subjects at high risk for Alzheimer's disease."

To validate the screening protocol, Dr. Pasinetti and his colleagues administered these drugs in mice that were genetically engineered to develop the hallmark amyloid plaques associated with Alzheimer's disease. After six months of treatment with blood pressure medicines, amyloid plaques and neurodegeneration were significantly reduced in the mice. One such medicine was Carvedilol, now under clinical investigation in Alzheimer 's disease with the intent to slow down memory deterioration.

"In recent years, amyloid plaques have become one of the main focal points in the search to understand and to treat Alzheimer's disease," said Dr. Pasinetti. "Thus, identifying novel dr
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Penn study cautions use of drugs to block niacin flush
3. Urinary Incontinence Drugs May Be More Trouble Than Theyre Worth
4. Discovery could help to develop drugs for organ transplant and cancer patients
5. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
6. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
7. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
8. Seniors Stop Taking Heart Drugs In Medicare Donut Hole
9. New Psoriasis Drugs Not Much Better Than Standard Therapy, Study Finds
10. About 1 baby born each hour addicted to opiate drugs in U.S., U-M study shows
11. Blood pressure drugs linked with lower PTSD symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Healthpointe is proud to announce that Dr. ... ankle reconstruction surgeries to assist patients with severe orthopedic ... in the diagnosis and treatment of sports medicine, and ... trained to perform advanced Foot and Ankle Reconstruction to ... also fluent in Spanish. , Reconstructive surgical procedures for ...
(Date:9/30/2014)... September 30, 2014 Catalent Pharma ... advanced delivery technologies and development solutions for drugs, ... full agenda for the 25th Annual CPhI Worldwide ... October 6th to 9th. , Catalent is showcasing ... expansions during the show, including its facilities in ...
(Date:9/30/2014)... CA (PRWEB) September 30, 2014 ... the grand opening of its newest practice, located at ... offers digital x-rays, general dentistry services , and ... surgery. In addition to providing affordable and convenient dental ... emergency dental appointments . Call Coast Dental at ...
(Date:9/30/2014)... CT (PRWEB) September 30, 2014 With accolades ... slot in Lash Masters II, Hilaree Brand of My Brand ... of the craft and, more importantly, the ability to teach. ... by solid credentials and a great reputation. , With a ... licensed as a Master of Aesthetics and as an Instructor. ...
(Date:9/30/2014)... (L-T4), long the standard of care for treating ... individuals do not regain optimal health on L-T4 ... to explain these differences. An expert task force ... replacement reviewed the latest studies on L-T4 therapy ... change to the current standard of care is ...
Breaking Medicine News(10 mins):Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 2Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 3Health News:Catalent Showcases Advanced Technologies and Supply Capabilities at CPhI Worldwide Conference and Exhibition 2Health News:Catalent Showcases Advanced Technologies and Supply Capabilities at CPhI Worldwide Conference and Exhibition 3Health News:Coast Dental Clovis Celebrates Grand Opening 2Health News:Coast Dental Clovis Celebrates Grand Opening 3Health News:My Brand Lashes and Lash Affair By J. Paris Merge to Offer Premium Lash and Brow Products and Certifications 2Health News:My Brand Lashes and Lash Affair By J. Paris Merge to Offer Premium Lash and Brow Products and Certifications 3Health News:New hypothyroidism treatment guidelines from American Thyroid Association 2
... Diseases Society of America (IDSA) released its first-ever guidelines for ... which will help physicians determine the most appropriate care for ... the most common cause of skin infections that send people ... people a year. Treatment of MRSA varies widely. ...
... HealthDay Reporter , TUESDAY, Jan. 4 (HealthDay News) ... seat belts, an increase that translates into many fewer injuries ... When the first state law requiring seat belts was ... wear them. But now, according to the U.S. Centers for ...
... , TUESDAY, Jan. 4 (HealthDay News) -- Levels ... suffer a type of heart attack called acute ST-segment elevation ... the most dangerous type of heart attack, STEMI occurs when ... large area of the heart. In the new ...
... Va. (Jan. 4, 2011) Virginia Commonwealth University School ... of an enzyme in the blood vessels of pregnant ... associated with the condition, including hypertension, swelling and protein ... a treatment for pregnant women with preeclampsia, which is ...
... , TUESDAY, Jan. 4 (HealthDay News) -- Rates of head ... including young women without any known risk factors. Now, a ... boosting the movement of precancerous cells in the mouth. ... handles estrogen after the lungs are exposed to smoke. This ...
... In the first combat-zone study of its kind, a ... with a positive outlook in the most traumatic situations were ... depression. The study, which surveyed Army troops fighting in ... who regularly deal with traumatic events such as death. Training ...
Cached Medicine News:Health News:IDSA announces first guidelines for treatment of MRSA infections 2Health News:IDSA announces first guidelines for treatment of MRSA infections 3Health News:IDSA announces first guidelines for treatment of MRSA infections 4Health News:Six Out of 7 Drivers Use Seat Belts: CDC 2Health News:Six Out of 7 Drivers Use Seat Belts: CDC 3Health News:Higher Education May Benefit Some Heart Attack Patients 2Health News:VCU findings may help explain some major clinical symptoms of preeclampsia 2Health News:Estrogen May Play Role in Rising Rates of Head, Neck Cancer 2Health News:MSU leads first study of resiliency on the battlefield 2
(Date:9/30/2014)... , Sept. 30, 2014  Decision Resources Group finds that ... Australia , China , ... expand at a strong rate through 2023. Dental implant procedure volumes ... as patient awareness rises. Other key findings from Decision ... dental implant market: , Dental implant penetration: Penetration ...
(Date:9/30/2014)... 30, 2014 A study using a relatively ... new look at the composition of carotid artery disease ... and treat the disease, a leading cause of stroke. ... Lexington between September 2010 and May 2012, was featured ... of the American College of Cardiology (JACC) Cardiovascular Interventions. ...
(Date:9/30/2014)... Sept. 30, 2014 BioStructures, LLC has ... Association of Tissue Banks (AATB), it was announced ... Officer. Accreditation follows an intensive nine-month ... trained AATB inspector.  It establishes that the level ... facility meets or exceeds the standards set by ...
Breaking Medicine Technology:Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2Biostructures, LLC Earns AATB Accreditation 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: