Navigation Links
Common stimulant may speed recovery from general anesthesia
Date:9/21/2011

e and histamine. The current study was designed to see whether methylphenidate could stimulate arousal in rats receiving the anesthetic drug isoflurane. The first experiments showed that animals receiving intravenous methylphenidate five minutes before discontinuation of isoflurane recovered significantly faster than did rats receiving a saline injection. Another experiment showed that methylphenidate induced signs of arousal movement, standing up, etc. in animals continuing to receive isoflurane at a dose that would have been sufficient to maintain unconsciousness. EEG readings taken during that experiment showed that brain rhythms associated with arousal returned within 30 seconds of methylphenidate administration. Giving a drug that interferes with the dopamine pathway blocked the arousal effects of methylphenidate, supporting the role of that pathway in the drug's effects.

"Our results tell us that, even though we don't yet know the precise mechanisms underlying general anesthesia, we can overcome its effects by activating arousal pathways," says Ken Solt, MD, of the MGH Department of Anesthesia, Critical Care and Pain Medicine, the paper's lead and corresponding author. "Instead of the traditional paradigm of reversing drug actions at the molecular level, methylphenidate acts at the level of neural circuits to overcome the effects of isoflurane. Since we still know very little about the pathways involved in general anesthesia, we will be testing the actions of methylphenidate with other anesthetic agents to see if these arousal effects are broadly applicable."

Brown adds, "More precise ways to induce and control the arousal process may lead to strategies that help patients recover from coma. We also found that methylphenidate increased respiration in anesthetized animals, which could help rescue patients who receive too much sedation for simple procedures. And the ability to safely reduce the time patients spend in the operating r
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Costly blood clots more common than expected among cancer patients
2. Sudden Cardiac Arrest More Common in Poorer Neighborhoods
3. Combination therapy rids common infection from implanted medical devices
4. Commonly used defibrillators raise risk of problems
5. Common bacterium stops mosquitoes from transmitting dengue virus
6. Common Heart Dysfunction Can Help Bring on Heart Failure
7. Study: Afghan patients a common source of drug-resistant bacteria
8. Researchers Say Theyve Found Common Cause of All Types of ALS
9. Study identifies new way to treat common hospital-acquired infection
10. New defense discovered against common hospital-acquired infection
11. Common vein condition increases risk for developing life-threating blood clots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... HealthDay Reporter TUESDAY, July 29, 2014 ... a single dose of the hormone oxytocin quickly improved their ... Known as the "love hormone," oxytocin has been shown ... between mothers and their children. In this study, it ... brain that has long been associated with the processing of ...
(Date:7/29/2014)... 2014 The Law Offices of Michael Cordova ... Hope, a non-profit organization providing grief camps for kids, teens, ... and suffering our clients experience from the death of a ... an organization like Stepping Stones of Hope, as they provide ... Stones of Hope also includes a monthly support group and ...
(Date:7/29/2014)... transplants receive steady follow-up care, the living donors ... follow-up care more accessible, UC San Francisco and ... launch the first program in the country that ... living kidney donors. , UCSF will provide vouchers ... 4,500 Walgreens pharmacies and Healthcare Clinic at select ...
(Date:7/29/2014)... A team of scientists, led by Western University ... a blood test for Alzheimer’s disease risk that may ... disease interventions, according to an article published July 29, ... study represents one of several pieces that have locked ... years,” Ethell said. , The study, “Women with the ...
(Date:7/29/2014)... Beach, Florida (PRWEB) July 29, 2014 Child ... scholarship for law students this week. The scholarship will help ... abused children and their families. , Steinger, Iscoe and Greene ... abuse, and want tomorrow’s attorneys to do the same. More ... each year according to the nonprofit Childhelp (retrieved ...
Breaking Medicine News(10 mins):Health News:'Love Hormone' Oxytocin May Help Some With Autism 2Health News:'Love Hormone' Oxytocin May Help Some With Autism 3Health News:The Law Offices of Michael Cordova is Sponsoring Stepping Stones of Hope, a Non-Profit Organization Providing Grief Camps for Kids, Teens, Adults, and Families 2Health News:Caring for donors 2Health News:Caring for donors 3Health News:Professor Develops Blood Test for Alzheimer’s Disease Risk 2Health News:Steinger, Iscoe & Greene Offers Child Advocate Scholarship 2
... device that effectively pulls the tongue closer to the jawbone ... of snoring and sleep apnea, suggest early results of a ... organs and the resulting sound due to obstructed air movement ... loud and unpleasant. It can sometimes be frustrating for patients ...
... are among celebrities whose sketches have been drawn with pig's ... Clarke, who created the artworks, says that he was inspired ... working for the police and analysing blood at crime scenes. ... these artworks by FX Channel to coincide with the launch ...
... conventionally grown products. A US study reports that organic ... risk of heart disease and stroke. ... produce found almost double the level of flavonoids - ... quercetin and kaempferol aglycones than their conventionally grown counterparts. ...
... have developed a new minimally invasive method of ... trials on individuals with prostate cancer soon . ... irreversible electroporation (IRE) is a result of the ... and University of California bioengineering professor Boris Rubinsky. ...
... San Fermin running of the bulls festival on Friday, with ... take their chances in the bull run . ... mention copious amounts of drinking -- in Pamplona in northeastern ... for the "encierro", when bulls are released onto the streets ...
... of computer gaming has brought some 700 players from 51 ... a sign of the growth of the "electronic sports" industry ... compete for a pool of 180,000 dollars (132,000 euros) in ... put on by the Games-Services company. It was taking place ...
Cached Medicine News:Health News:New Device to Treat Snoring and Sleep Apnea 2Health News:Organically Grown Food More Healthier 2Health News:Scientists Destroy Cancer Cells Using Electric Pulses 2
(Date:7/29/2014)... YORK , July 29, 2014  Longtime industry ... Caremark Rx, Drew Crawford today announced the ... the leading independent media source dedicated to delivering fair, ... on the pharmacy benefit management (PBM) industry .  ... of, and context behind, industry news.   The outlet will ...
(Date:7/29/2014)... , July 29, 2014 McGraw-Hill Education Professional, ... the science, technical, and medical communities, has announced the ... off-line mobile application of the world-renowned medical education platform. ... AccessMedicine App , available for download onto all ... be able to gain access to valuable AccessMedicine ...
(Date:7/29/2014)... According to a new market ... Devices Market - Global Forecast, Market Share, Size, Growth ... trauma fixation devices market is estimated at USD 6.1 ... a CAGR of 7.2% from 2014 to 2019, to ... 2020. Browse the Orthopedic Trauma Fixation Devices ...
Breaking Medicine Technology:Drew Crawford Announces Launch of PBM365 Media 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: