Navigation Links
Common painkillers linked to irregular heart rhythm
Date:7/4/2011

Commonly used painkillers to treat inflammation are linked to an increased risk of irregular heart rhythm (known as atrial fibrillation or flutter), concludes a study published on bmj.com today.

The drugs include non-selective non-steroidal anti-inflammatory drugs (NSAIDS) as well as new generation anti-inflammatory drugs, known as selective COX-2 inhibitors.

These drugs have already been linked to an increased risk of heart attacks and strokes, but no study has examined whether they increase the risk of atrial fibrillation a condition which is associated with an increased long term risk of stroke, heart failure, and death.

So a team of researchers, led by Professor Henrik Toft Srensen at Aarhus University Hospital in Denmark, used the Danish National Registry of Patients to identify 32,602 patients with a first diagnosis of atrial fibrillation or flutter between 1999 and 2008. Each case was compared with 10 age and sex-matched control patients randomly selected from the Danish population.

Patients were classified as current or recent NSAID users. Current users were further classified as new users (first ever prescription within 60 days of diagnosis date) or long-term users.

The researchers found that use of NSAIDs or COX-2 inhibitors was associated with an increased risk of atrial fibrillation or flutter.

Compared with non users, the association was strongest for new users, with around 40% increased risk for non-selective NSAIDS and around 70% increased risk for COX-2 inhibitors. This is equivalent to approximately four extra cases of atrial fibrillation per year per 1000 new users of non-selective NSAIDS and seven extra cases of atrial fibrillation per 1000 new users of COX-2 inhibitors.

The risk appeared highest in older people, and patients with chronic kidney disease or rheumatoid arthritis were at particular risk when starting treatment with COX-2 inhibitors.

The authors conclude: "Our study thus adds evidence that atrial fibrillation or flutter need to be added to the cardiovascular risks under consideration when prescribing NSAIDs."

This view is supported by an accompanying editorial by Professor Jerry Gurwitz from the University of Massachusetts Medical School in the US. He believes that NSAIDS should continue to be used very cautiously in older patients with a history of hypertension or heart failure . regardless of whether an association between NSAIDs and atrial fibrillation actually exists.


'/>"/>

Contact: Emma Dickinson
edickinson@bmjgroup.com
44-207-383-6529
BMJ-British Medical Journal
Source:Eurekalert

Related medicine news :

1. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
2. Sexting Common for Those Who Cheat: Study
3. Common drugs linked to cognitive impairment and possibly to increased risk of death
4. Diagnosed autism is more common in an IT-rich region
5. Can Weight-Loss Surgery Reverse Common Cause of Infertility?
6. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
7. New research provides breakthrough in understanding common cancer
8. Bursitis a common cause of painful hips, knees, heels and elbows
9. Reducing a severe side effect of a common anticancer drug
10. Common transplant drug inhibits breast cancer growth, UNC laboratory study shows
11. Common test could help predict early death in diabetes, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... August 16, 2017 , ... Any Lab Test Now® ... company ranked #4429 on the newly released, 36th annual Inc. 5000 , the ... look at the most successful companies within the American economy’s most dynamic segment — ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... doors. They celebrate 30 years in business this year, and they’re marking the ... tranquil space to serve their patients. , It stands to reason that, ...
(Date:8/16/2017)... ... August 16, 2017 , ... QualDerm Partners , a ... today announced Cumberland Skin Surgery and Dermatology has joined the company ... in both Hermitage and Lebanon, Tennessee, provides comprehensive general dermatology and skin cancer ...
(Date:8/16/2017)... ... 2017 , ... Maury Regional Health has announced a large-scale adoption of AccuVein ... devices, Maury Regional Medical Center is making vein visualization part of their standard of ... and more importantly, helps our staff members locate a vein that will provide good ...
(Date:8/16/2017)... ... August 16, 2017 , ... Paul Vitenas, MD, FACS , is honored ... The annual list identifies the nation’s top physicians, in a variety of specialties. This ... the top of Castle Connolly’s coveted ranking. , Castle Connolly is the nation’s trusted ...
Breaking Medicine News(10 mins):
(Date:7/25/2017)... BARCELONA, Spain and CAMBRIDGE, Massachusetts ... SOM Biotech, specializing in repurposing drugs to treat rare nervous ... Therapeutics Inc. to clinically develop and market the drug SOM0226 ... reached, the drug achieved very promising results in a Phase ... A new office in the United ...
(Date:7/24/2017)... , July 24, 2017 IBM (NYSE: ... Gartner Magic Quadrant for Solid-State Arrays (SSA) for the fourth ... According to Gartner, "Vendors in the Leaders quadrant ... Completeness of Vision. A vendor in the Leaders quadrant has ... to drive the acceptance of new technologies. These vendors demonstrate ...
(Date:7/21/2017)... EDMONTON, Alberta , July 21, 2017 ... the University of Alberta in Edmonton, ... Nature,s partner journal, Schizophrenia 1 , demonstrating that ... of schizophrenia with 74% accuracy. This retrospective analysis ... specific symptoms in schizophrenia patients with significant correlation, ...
Breaking Medicine Technology: