Navigation Links
Common painkillers linked to irregular heart rhythm
Date:7/4/2011

Commonly used painkillers to treat inflammation are linked to an increased risk of irregular heart rhythm (known as atrial fibrillation or flutter), concludes a study published on bmj.com today.

The drugs include non-selective non-steroidal anti-inflammatory drugs (NSAIDS) as well as new generation anti-inflammatory drugs, known as selective COX-2 inhibitors.

These drugs have already been linked to an increased risk of heart attacks and strokes, but no study has examined whether they increase the risk of atrial fibrillation a condition which is associated with an increased long term risk of stroke, heart failure, and death.

So a team of researchers, led by Professor Henrik Toft Srensen at Aarhus University Hospital in Denmark, used the Danish National Registry of Patients to identify 32,602 patients with a first diagnosis of atrial fibrillation or flutter between 1999 and 2008. Each case was compared with 10 age and sex-matched control patients randomly selected from the Danish population.

Patients were classified as current or recent NSAID users. Current users were further classified as new users (first ever prescription within 60 days of diagnosis date) or long-term users.

The researchers found that use of NSAIDs or COX-2 inhibitors was associated with an increased risk of atrial fibrillation or flutter.

Compared with non users, the association was strongest for new users, with around 40% increased risk for non-selective NSAIDS and around 70% increased risk for COX-2 inhibitors. This is equivalent to approximately four extra cases of atrial fibrillation per year per 1000 new users of non-selective NSAIDS and seven extra cases of atrial fibrillation per 1000 new users of COX-2 inhibitors.

The risk appeared highest in older people, and patients with chronic kidney disease or rheumatoid arthritis were at particular risk when starting treatment with COX-2 inhibitors.

The authors conclude: "Our study thus adds evidence that atrial fibrillation or flutter need to be added to the cardiovascular risks under consideration when prescribing NSAIDs."

This view is supported by an accompanying editorial by Professor Jerry Gurwitz from the University of Massachusetts Medical School in the US. He believes that NSAIDS should continue to be used very cautiously in older patients with a history of hypertension or heart failure . regardless of whether an association between NSAIDs and atrial fibrillation actually exists.


'/>"/>

Contact: Emma Dickinson
edickinson@bmjgroup.com
44-207-383-6529
BMJ-British Medical Journal
Source:Eurekalert

Related medicine news :

1. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
2. Sexting Common for Those Who Cheat: Study
3. Common drugs linked to cognitive impairment and possibly to increased risk of death
4. Diagnosed autism is more common in an IT-rich region
5. Can Weight-Loss Surgery Reverse Common Cause of Infertility?
6. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
7. New research provides breakthrough in understanding common cancer
8. Bursitis a common cause of painful hips, knees, heels and elbows
9. Reducing a severe side effect of a common anticancer drug
10. Common transplant drug inhibits breast cancer growth, UNC laboratory study shows
11. Common test could help predict early death in diabetes, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... ... Liposuction specialist Marcia V. Byrd, MD spoke last month at the Fat Disorders ... Airport Hotel. This year’s conference was titled “Living with Lipedema and Dealing with Dercum’s ... treating Lipedema. Dr. Byrd is considered one of the leading physicians in the country ...
(Date:5/5/2016)... ... 05, 2016 , ... Linfield College Online and Continuing Education is encouraging registered ... $50 application fee for all qualified applicants from May 1–14. Students need only go ... when applying . , With the RN to BSN degree program, ...
(Date:5/5/2016)... ... May 05, 2016 , ... Nepenthe Laboratory Services (NLS), a premier ... week to raise non-perishable food item donations for Food for Lane County, and to ... NBC. , “The goal of the assembly was to create an exciting atmosphere for ...
(Date:5/5/2016)... , ... May 05, 2016 , ... In the midst ... to forget the most important arrangement — planning a safe way of getting home ... popular tequila drinks. Unfortunately, these celebrations often lead to drunk drivers on the roads ...
(Date:5/5/2016)... ... , ... Augusta Public Schools has teamed with CareDox to provide confidential and ... offices to streamline and bolster care for district students. , Augusta School District, ... schools serve 2,300 students among its six schools. , Monica Guilliams, BSN, RN, ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Holdings (NYSE: CODI ) ("CODI," "we," "our" ... businesses, announced today its consolidated operating results for the ... Quarter 2016 Highlights , Generated Cash Flow Available ... $13.6 million for the first quarter of 2016; ... first quarter of 2016; , Paid a first ...
(Date:5/4/2016)... New York , May 4, 2016 ... by Transparency Market Research entitled "Brain Computer Interface Market - ... 2016 - 2024," the  global brain computer interface (BCI) market ... by 2024. The market is estimated to expand at ... from 2016 to 2024. A BCI device ...
(Date:5/4/2016)... , May 4, 2016  It,s time for an upgrade. There are many ... a brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity and ... well as a world class manufacturer of innovative technology.  Photo - ... ... ...
Breaking Medicine Technology: