Navigation Links
Common painkillers linked to irregular heart rhythm
Date:7/4/2011

Commonly used painkillers to treat inflammation are linked to an increased risk of irregular heart rhythm (known as atrial fibrillation or flutter), concludes a study published on bmj.com today.

The drugs include non-selective non-steroidal anti-inflammatory drugs (NSAIDS) as well as new generation anti-inflammatory drugs, known as selective COX-2 inhibitors.

These drugs have already been linked to an increased risk of heart attacks and strokes, but no study has examined whether they increase the risk of atrial fibrillation a condition which is associated with an increased long term risk of stroke, heart failure, and death.

So a team of researchers, led by Professor Henrik Toft Srensen at Aarhus University Hospital in Denmark, used the Danish National Registry of Patients to identify 32,602 patients with a first diagnosis of atrial fibrillation or flutter between 1999 and 2008. Each case was compared with 10 age and sex-matched control patients randomly selected from the Danish population.

Patients were classified as current or recent NSAID users. Current users were further classified as new users (first ever prescription within 60 days of diagnosis date) or long-term users.

The researchers found that use of NSAIDs or COX-2 inhibitors was associated with an increased risk of atrial fibrillation or flutter.

Compared with non users, the association was strongest for new users, with around 40% increased risk for non-selective NSAIDS and around 70% increased risk for COX-2 inhibitors. This is equivalent to approximately four extra cases of atrial fibrillation per year per 1000 new users of non-selective NSAIDS and seven extra cases of atrial fibrillation per 1000 new users of COX-2 inhibitors.

The risk appeared highest in older people, and patients with chronic kidney disease or rheumatoid arthritis were at particular risk when starting treatment with COX-2 inhibitors.

The authors conclude: "Our study thus adds evidence that atrial fibrillation or flutter need to be added to the cardiovascular risks under consideration when prescribing NSAIDs."

This view is supported by an accompanying editorial by Professor Jerry Gurwitz from the University of Massachusetts Medical School in the US. He believes that NSAIDS should continue to be used very cautiously in older patients with a history of hypertension or heart failure . regardless of whether an association between NSAIDs and atrial fibrillation actually exists.


'/>"/>

Contact: Emma Dickinson
edickinson@bmjgroup.com
44-207-383-6529
BMJ-British Medical Journal
Source:Eurekalert

Related medicine news :

1. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
2. Sexting Common for Those Who Cheat: Study
3. Common drugs linked to cognitive impairment and possibly to increased risk of death
4. Diagnosed autism is more common in an IT-rich region
5. Can Weight-Loss Surgery Reverse Common Cause of Infertility?
6. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
7. New research provides breakthrough in understanding common cancer
8. Bursitis a common cause of painful hips, knees, heels and elbows
9. Reducing a severe side effect of a common anticancer drug
10. Common transplant drug inhibits breast cancer growth, UNC laboratory study shows
11. Common test could help predict early death in diabetes, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... April 29, 2017 , ... More than half of Americans suffering from ... in their leisure time that causes hearing loss? May 1 marks the beginning of ... to hearing loss, as well as schedule a hearing evaluation for anyone with concerns ...
(Date:4/28/2017)... ... April 28, 2017 , ... Accreditation Commission for Health Care ... of America (HCAOA). This agreement allows HCAOA members to receive special pricing on ... on Accreditation University (AU) educational resources that help prepare HCAOA members for ACHC ...
(Date:4/28/2017)... ... April 28, 2017 , ... Horizon Blue Cross Blue Shield of New Jersey ... “A” and its outlook as “stable.” At the same time, the ratings agency cautioned ... recent years, dip below “capital adequacy” thresholds required for its strong rating. , “Horizon ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... tubes . These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps ... fixtures or disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ...
(Date:4/28/2017)... Texas (PRWEB) , ... April 28, 2017 , ... The ... plaque in recently to the labor and delivery team at Women’s Hospital at Renaissance ... mothers who give birth at the hospital and decide to donate. , “Women’s ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... April 18, 2017 Viverae ® , a ... the integration of IBM ® Watson Campaign Automation, ... targeted communications for a personalized experience. Through digital engagement, ... their health in real time. The enhanced experience drives ... to members, wherever they are in their journey to ...
(Date:4/18/2017)... , April 18, 2017  Astute Medical, Inc., ... case series to be presented at the 2017 National ... begins today and continues through April 22. Physicians will ... , used to assess risk for acute kidney injury ... heart failure (ADHF). Elevated levels of ...
(Date:4/18/2017)... 2017  Socionext Inc. and SOINN Inc. today ... in which Socionext extracts and delivers biometrics data ... initial results in reading ultrasound images from Socionext,s ... The results will be introduced at Medtec Japan, ... booths 4505 & 4507. In this ...
Breaking Medicine Technology: