Navigation Links
Common painkillers linked to irregular heart rhythm
Date:7/4/2011

Commonly used painkillers to treat inflammation are linked to an increased risk of irregular heart rhythm (known as atrial fibrillation or flutter), concludes a study published on bmj.com today.

The drugs include non-selective non-steroidal anti-inflammatory drugs (NSAIDS) as well as new generation anti-inflammatory drugs, known as selective COX-2 inhibitors.

These drugs have already been linked to an increased risk of heart attacks and strokes, but no study has examined whether they increase the risk of atrial fibrillation a condition which is associated with an increased long term risk of stroke, heart failure, and death.

So a team of researchers, led by Professor Henrik Toft Srensen at Aarhus University Hospital in Denmark, used the Danish National Registry of Patients to identify 32,602 patients with a first diagnosis of atrial fibrillation or flutter between 1999 and 2008. Each case was compared with 10 age and sex-matched control patients randomly selected from the Danish population.

Patients were classified as current or recent NSAID users. Current users were further classified as new users (first ever prescription within 60 days of diagnosis date) or long-term users.

The researchers found that use of NSAIDs or COX-2 inhibitors was associated with an increased risk of atrial fibrillation or flutter.

Compared with non users, the association was strongest for new users, with around 40% increased risk for non-selective NSAIDS and around 70% increased risk for COX-2 inhibitors. This is equivalent to approximately four extra cases of atrial fibrillation per year per 1000 new users of non-selective NSAIDS and seven extra cases of atrial fibrillation per 1000 new users of COX-2 inhibitors.

The risk appeared highest in older people, and patients with chronic kidney disease or rheumatoid arthritis were at particular risk when starting treatment with COX-2 inhibitors.

The authors conclude: "Our study thus adds evidence that atrial fibrillation or flutter need to be added to the cardiovascular risks under consideration when prescribing NSAIDs."

This view is supported by an accompanying editorial by Professor Jerry Gurwitz from the University of Massachusetts Medical School in the US. He believes that NSAIDS should continue to be used very cautiously in older patients with a history of hypertension or heart failure . regardless of whether an association between NSAIDs and atrial fibrillation actually exists.


'/>"/>

Contact: Emma Dickinson
edickinson@bmjgroup.com
44-207-383-6529
BMJ-British Medical Journal
Source:Eurekalert

Related medicine news :

1. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
2. Sexting Common for Those Who Cheat: Study
3. Common drugs linked to cognitive impairment and possibly to increased risk of death
4. Diagnosed autism is more common in an IT-rich region
5. Can Weight-Loss Surgery Reverse Common Cause of Infertility?
6. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
7. New research provides breakthrough in understanding common cancer
8. Bursitis a common cause of painful hips, knees, heels and elbows
9. Reducing a severe side effect of a common anticancer drug
10. Common transplant drug inhibits breast cancer growth, UNC laboratory study shows
11. Common test could help predict early death in diabetes, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... TherapySites, the leading website and ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to extend ... exclusive benefits and promotional offers. , "TCA is extremely excited about this new ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: