Navigation Links
Common pain relief medication may encourage cancer growth
Date:11/18/2009

Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells. Two new studies advance that argument and demonstrate how shielding lung cancer cells from opiates reduces cell proliferation, invasion and migration in both cell-culture and mouse models.

The reports--to be presented November 18, 2009, at "Molecular Targets and Cancer Therapeutics," a joint meeting in Boston of the American Association for Cancer Research, the National Cancer Institute, and the European Organization for Research and Treatment of Cancer--highlight the mu opiate receptor, where morphine works, as a potential therapeutic target.

"If confirmed clinically, this could change how we do surgical anesthesia for our cancer patients," said Patrick A. Singleton, PhD, assistant professor of medicine at the University of Chicago Medical Center and principal author of both studies. "It also suggests potential new applications for this novel class of drugs which should be explored."

The proposition that opiates influence cancer recurrence, prompted by several unrelated clinical and laboratory studies, has gradually gained support. It started with a 2002 palliative-care trial in which patients who received spinal rather than systemic pain relief survived longer. Soon after that, Singleton's colleague, anesthesiologist Jonathan Moss, noticed that several cancer patients receiving a selective opiate blocker in a compassionate-use protocol lived longer than expected. Two recent retrospective studies found that breast and prostate cancer patients who received regional rather than general anesthesia had fewer recurrences. In February, 2009, the Anesthesia Patient Safety Foundation highlighted the issue.

Moss's palliative-care patients were taking methylnaltrexone (MNTX), developed in the 1980s for
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UK junior doctors gaining less experience of common procedures
2. New insights into common knee injuries
3. High and mighty: first common height gene identified by researchers behind obesity gene finding
4. Figure Skater Peggy Fleming, HealthSaver Says: Take Pains For Back Strains, 2nd Most Common Doctor Complaint
5. Exelixis Commences Public Offering of Common Stock
6. Common misdiagnosis: most women believe they have a yeast infection when they dont
7. Business Executives Discuss National Health Care Reform at Conference Sponsored by The Century Foundation, with Support from The Commonwealth Fund, and AARP
8. New Expert Report Dispels Common Myths About Aspartame
9. Common Foot Myths Trip Us Up
10. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
11. Allergy-Induced Asthma More Common in Affluent Countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2015)... May 23, 2015 Injury lawyer Steven H. ... been passed by the Maryland legislature but which has not ... General Assembly passed HB 449 with overwhelming bipartisan ... not signed it into law. This bill ensures that fracking ... growing that demonstrates the danger of fracking to our water ...
(Date:5/22/2015)... 2015 The American College of Traditional ... June. They will hold a webinar on the updates ... class on Classical Chinese Medicine. , Webinar – First ... Given, the Dean of Clinical Education, will lead this ... Professional Doctorate program. ACTCM is currently developing this degree ...
(Date:5/22/2015)... 22, 2015 Hundreds of federal ... of individuals who allegedly experienced serious internal bleeding ... to move forward in the U.S. District Court, ... Order dated May 4, 2015, the Court has ... electronically stored information. Among other things, the Order ...
(Date:5/22/2015)... Combination therapy, or polytherapy, will ... obstructive pulmonary disorder (COPD) as the dominant companies ... as well as Germany’s Boehringer Ingelheim compete with ... will market payers, clinicians and patients be disposed ... completely new ones? , In spite of recently ...
(Date:5/22/2015)... Family, friends, students, colleagues, mentors and fellow ... LaSalle D. Leffall, on Monday, May 18, with an ... Rounds in the hospital’s Tower Auditorium. Leffall’s younger sister, ... trying to keep the secret. “I’d like to go ... he’ll know something is up,” she said. , After ...
Breaking Medicine News(10 mins):Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:ACTCM Announces Upcoming June Events 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2
... Ashley Judd will be here on a three-day visit to ... and maternal and child health.// ,The star of ... Crimes" will be visiting the Rajasthan capital as part of ... member of PSI (earlier known as Population Services International) and ...
... Australian scientists now look to honey as a solution, to fight ... Hospital in Middlesbrough were inspired by the use of honey by ... as a dressing for their wounds. , Mention of ... as the Charaka and Susrutha Samhitis, and the Bible as well. ...
... taken over as the Director General of Army's Medical Services ... College, Nagpur he was commissioned into the Army Medical Corps ... Pune University in 1977, he completed training in Radiation Oncology ... from Bombay University. ,A pioneer in the ...
... a pharmaceutical drug named Sunitinib in halting the ... of interferon and// sunitinib treatments found that sunitinib ... metastatic kidney cancer. ,The work was ... The New England Journal of Medicine and involved ...
... of the journal SLEEP finds that people with obstructive ... disease.// ,The study attributes the increased link ... a rising prevalence. Results suggest that OSA plays a ... hypertension. ,"There is abundant physiologic evidence ...
... could affect your judgment, suggests a new study.// ... affect brain function. Now William Killgore and colleagues at ... Spring, Maryland, US, studied 26 healthy adults, all of ... researchers found that sleep deprivation has a particularly debilitating ...
Cached Medicine News:Health News:A New Drug for Halting Metastatic Kidney Cancer 2Health News:Sleep Well, Have a Healthy Heart ! 2
(Date:5/22/2015)... NEW YORK , May 22, 2015 /PRNewswire/ ... segment of the $13 billion global cardiac rhythm ... Kalorama Information.  Kalorama found that Medtronic, St. Jude ... Medical) command 80% of this market segment. The ... Management Device Markets , uses 2015 as a ...
(Date:5/22/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... of the results of the Company,s 72-patient, placebo-controlled ... drops) for the treatment of dry eye patients ... ) model.  The exploratory study was completed in ... disseminated by the Company in a press release, ...
(Date:5/22/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3rthk2/latest ) ... Regulations on Pharmaceutical International Multi-Center Clinical Trials in ... This is first time in history, Chinese pharmaceutical ... clinical trials of drugs in China ... on March 1, 2015. The guidance provides an ...
Breaking Medicine Technology:Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 42015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... , , NEW YORK , ... Jay Hoffman , PhD, professor and chair of the Department of ... , has shown Sustamine™ L-Alanyl-L-Glutamine, increases performance in endurance exercise and ... in the Journal of the International Society of Sports Nutrition ...
... , SEATTLE , Feb. 11 ... today announced record 2009 sales results. The successful launch of ... in excess of 75% and the company,s first cash flow ... the company,s manufacturing capacity for 2009 and well into 2010. ...
Cached Medicine Technology:Clinical Study Shows Sustamine(TM) L-Alanyl-L-Glutamine Increases Performance in Endurance, Exercise and Activity 2Clinical Study Shows Sustamine(TM) L-Alanyl-L-Glutamine Increases Performance in Endurance, Exercise and Activity 3Clinical Study Shows Sustamine(TM) L-Alanyl-L-Glutamine Increases Performance in Endurance, Exercise and Activity 4Amnis Announces Record 2009 Sales 2
... can choose either the PARI LC PLUS® or ... to both:, ,Maximize aerosol output when the ... patient exhales using two one-way valves. Baffles allow ... The result is a high percentage of particles ...
... with metered dose inhalers., ,ACE ensures ... MDI canisters. Its versatile design allows it ... in conjunction with an endotracheal airway or ... ACE may also be used in conjunction ...
... Kit Nebulizer Small Volume Medication W/Adult Mask ... Tubing Tee Adapter , ,An ... , ,Provide fine particles with a ... than conventional nebulizers, ,Our AirLife™ brand ...
... Products, ,Westmed designs, manufacturers and markets ... Respiratory professionals. Our mission is to design ... ability to deliver quality medical care while ... , ,Our web site is designed ...
Medicine Products: