Navigation Links
Common molecule notifies immune system of prostate cancer
Date:1/10/2008

In experiments with mice, researchers have found that the bodys immune system can use a surprisingly common molecule to recognize prostate tumors. The molecule comes from a protein found in all cells of the body; however, immune cells appear to respond to it only when it is present on the surface of cells within a tumor.

Understanding how this protein, known as histone H4, signals the immune system to respond to malignant cells may help researchers refine immunotherapy strategies that harness the body's own immune system to fight tumors. Some types of immunotherapy are already being tested in patients, but many questions remain unanswered. In particular, researchers want to know if tumor cells display molecular signposts that tell the immune system, I'm a cancer cell, destroy me.

Howard Hughes Medical Institute investigator James P. Allison and his team report finding one such signpost in prostate tumors in mice. The finding points toward possible improvements in immunotherapy.

We know very little about how the immune system responds to tumors, especially early tumors, said Allison, director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center in New York. Is the tumor at that stage invisible, or can immune cells detect it? And if they can detect it, can they mount a response? Those are the two big questions.

Allison's research, published in the January 11, 2008, issue of Science, found that immune cells can, in fact, detect prostate cancer, at least in lab mice. However, the immune system mounts only a feeble attack against the tumor.

But the signpost Allison's team identified might make revving up that feeble response much easier.

The strategy relies on a specific type of immune system cell called a killer T cell. Each of these cells bristles with thousands of receptors that recognize molecules that do not belong in the body. When a T cell recognizes a foreign molecule
'/>"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. GHI and HIP Launch Pilot Medical Home Network Project with Support from Commonwealth Fund
2. Multiple skin cancer risk behaviors are common among US adults
3. Catheter chaos: Hospitals lag in preventing common infection
4. Colon cancer risk in US traced to common ancester
5. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
6. Constipation most common cause of childrens abdominal pain
7. Brookdale Announces Fourth Quarter Common Stock Dividend of $0.50
8. Schering-Plough Declares Quarterly Dividends on Common Shares and 2007 Mandatory Convertible Preferred Stock
9. American Stock Exchange Lists the Common Stock and Units of The Quantum Group, Inc.
10. BioMed Realty Trust Declares Fourth Quarter 2007 Common Stock and Preferred Stock Dividends
11. Common Infant Vaccine Recalled
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... October 20, 2014 Recently, BambooIndustry.com, one ... unveiled its new range of bamboo deckings . ... these natural items; they are now available at deeply ... people, it is hard to overstate the significance of ... attention to online services. The company’s workers are striving ...
(Date:10/19/2014)... October 20, 2014 This report ... Partial Seizure, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ... and press releases. It also reviews key players ... and special features on late-stage and discontinued projects. ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest ... and HostMonster are the best VPS hosting suppliers ... is the method of partitioning a physical server ... the appearance and capabilities of running on someone’s ... pays close attention to VPS products and related ...
(Date:10/19/2014)... SweetDressy.com, a professional company of women’s dresses and related ... evening dresses . All the company’s old and new ... is up to 66 percent off. , SweetDressy.com ... field. Its dress specialists are striving to make more ... the world. All the company’s items are unique, graceful ...
(Date:10/19/2014)... NY (PRWEB) October 20, 2014 Stephen T. ... has been nominated for the 10th consecutive year as one ... year Dr. Greenberg was also been nominated as the best ... was also nominated as best Day Spa and best Laser ... until December 14th and readers can vote for the contest ...
Breaking Medicine News(10 mins):Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Promotion For Beautiful Long Evening Dresses Launched By SweetDressy.com 2Health News:Dr. Stephen T. Greenberg – Nominated for the 10th Consecutive Year for One of Long Island’s Best Cosmetic Surgeons for 2015 by the Long Island Press 2
... ... to educate people about ,bipolar disorder , , ... Wilmington, DE (PRWEB) November 11, 2009 -- As part of a panel ... firsthand by this disease. Debi was joined in New York by people living with ...
... Pa., Nov. 12 You,re visiting the dentist for what ... or she says you need a root canal. Though it,s ... one in the chair, you may have several questions and ... feared root canals for quite some time. The Pennsylvania Dental ...
... an industry faced with unprecedented uncertainty. One of the ... and clearly communicate relevant and timely messages to an ... & Krause (GY&K) reaffirmed its commitment to exceptional healthcare ... six national CardioVascular Advertising (CVA) Awards. , "Our ...
... GREENGUARD product certification pilot significantly expands chemical emissions ... harmful chemicals from products used in multiple environments. ... Environmental Institute (GEI) announces the launch of GREENGUARD ... existing stringent indoor air quality criteria, additional chemical ...
... Mesa Laboratories, Inc. (Nasdaq: MLAB ) today announced that ... of $.11 per share of common stock, up from $.10 ... December 15, 2009, to shareholders of record on November 30, ... maintained strong cash positions and has continued to build its ...
... WILMINGTON, Del., Nov. 12 Christiana Care ... first community hospital in the nation to submit specimens ... Genome Atlas (TCGA) Project. The project is part of ... to help doctors diagnose, treat and even prevent cancer ...
Cached Medicine News:Health News:Actress Debi Mazar Talks About her Family's Experience with Bipolar Depression 2Health News:Actress Debi Mazar Talks About her Family's Experience with Bipolar Depression 3Health News:Painful Root Canals Are a Thing of the Past 2Health News:Healthcare Organizations Face Tough Marketing Challenges - GY&K Asks 'Are You Relevant?' 2Health News:Healthcare Organizations Face Tough Marketing Challenges - GY&K Asks 'Are You Relevant?' 3Health News:GREENGUARD Launches Comprehensive Health-Based Certification Pilot Program 2Health News:Christiana Care First Community Hospital to Submit Samples to Cancer Genome Atlas Project 2
(Date:10/19/2014)... SEATTLE, Wash. , Oct. 20, 2014 ... today that it will report its third quarter 2014 ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... PDT). Access to the event can be obtained as ...
(Date:10/18/2014)... WASHINGTON , Oct. 18, 2014  In ... Human Rights Campaign (HRC), the nation,s largest lesbian, ... explicitly endorsed the use of Truvada for Pre-Exposure ... health tool used to prevent the spread of ... is the only brand name anti-HIV drug combination ...
(Date:10/17/2014)... Texas , Oct. 17, 2014  Hanger, Inc. ... plans to report its results of operations for the ... 2014 after the market closes.  A conference call to ... a.m., ET, on Friday, November 7, 2014. Those wishing ... available until Friday, November 14, 2014 by dialing 1-855-859-2056 ...
Breaking Medicine Technology:CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3
... blood oxygenation can be an essential element of ... clinical setting is often desirable. In keeping with ... easily used point-of-care devices, recent products from several ... Inc., Lake Forest, Calif., says that its HemoCue ...
... still seem radically innovative in the context of many ... been the norm for many years. In automobile assembly, ... with only occasional human oversight. The result has been ... returns in profit and productivity. These days, only a ...
Cached Medicine Technology:Hemoglobin Testing at the Point of Care 2Hemoglobin Testing at the Point of Care 3Lab Automation Networks Proliferating 2Lab Automation Networks Proliferating 3Lab Automation Networks Proliferating 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: