Navigation Links
Common household pesticides linked to childhood cancer cases in Washington area
Date:7/28/2009

Washington, DC A new study by researchers at the Georgetown's Lombardi Comprehensive Cancer Center finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops most commonly between three and seven years of age. The findings are published in the August issue of the journal Therapeutic Drug Monitoring.

Researchers caution that these findings should not be seen as cause-and-effect, only that the study suggests an association between pesticide exposure and development of childhood ALL.

"In our study, we compared urine samples from children with ALL and their mothers with healthy children and their moms. We found elevated levels of common household pesticides more often in the mother-child pairs affected by cancer," says the study's lead investigator, Offie Soldin, PhD, an epidemiologist at Lombardi. Soldin cautions, "We shouldn't assume that pesticides caused these cancers, but our findings certainly support the need for more robust research in this area."

The study was conducted between January 2005 and January 2008 with volunteer participants from Lombardi and Children's National Medical Center who live in the Washington metropolitan area. It included 41 pairs of children with ALL and their mothers (cases), and 41 pairs of healthy children and their mothers (controls). For comparison purposes, the case pairs were matched with control pairs by age, sex and county of residence. Previous studies in agricultural areas of the country have suggested a relationship between pesticides and childhood cancers, but researchers say this is the first study conducted in a large, metropolitan area.

Urine samples were collected from all child-mother pairs and analyzed by the Centers for Disease Control and Prevention to look for evidence of organophosphates (OP), the chemical name of some household pesticides. The body breaks down OP into metabolites which can be tracked in urine samples. The researchers say pesticides were detected in the urine of more than half of the participants, but levels of two common OP metobolites, diethylthiophosphate (DETP) and diethyldithiophosphate (DEDTP), were higher in the children with ALL compared to the control children (p< 0.03 and p< 0.05).

Also for the study, the mothers completed a questionnaire to collect information about the family's exposure to pesticides, their medical history, home and neighborhood characteristics, diet, and history of smoke exposure. More case mothers (33 percent) than controls (14 percent) reported using insecticides in the home (p< 0.02), however there was no correlation found between high levels of the OP metabolites in urine and reported use of pesticides.

"We know pesticides sprays, strips, or 'bombs,' are found in at least 85 percent of households, but obviously not all the children in these homes develop cancer. What this study suggests is an association between pesticide exposure and the development of childhood ALL, but this isn't a cause-and-effect finding," Soldin explains. "Future research would help us understand the exact role of pesticides in the development of cancer. We hypothesize that pre-natal exposure coupled with genetic susceptibility or an additional environmental insult after birth could be to blame."


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Related medicine news :

1. Emdeon Inc. Commences U.S. Initial Public Offering of Class A Common Stock
2. PharmAthene, Inc. Announces $19.3 Million Private Placement of Convertible Notes and Common Stock Warrants
3. Vitamin Shoppe Files Registration Statement for Initial Public Offering of Common Stock
4. Orexigen(R) Therapeutics Prices Public Offering of Common Stock
5. Cell Therapeutics, Inc. Announces Public Offering of Common Stock and Warrants
6. Orexigen(R) Therapeutics Announces Proposed Public Offering of Common Stock
7. NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X
8. Misdiagnosis of disorders of consciousness still commonplace
9. Gene linked to increasingly common type of blood cancer
10. Exposure to Common Pollutant in Womb Might Lower IQ
11. Bradmer to repurchase up to 8.3 million of its common shares pursuant to a substantial issuer bid
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... December 06, 2016 , ... An ... much-anticipated HydroFX for Water®. This first-of-its-kind water-soluble powder supplement has a unique ... most powerful antioxidants, molecular hydrogen, HydroFX for Water transforms every day water ...
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... Keeping Gift ... people choose gifts that are safe and age-appropriate for their recipients. This is the ... to reflect on the safety of items that would make good gifts for children. ...
(Date:12/6/2016)... ... December 06, 2016 , ... Specialty Technical Publishers (STP) ... Audit Protocol Consortium (IAPC) EHS audit protocol for Great Britain . Leading ... of their EHS regulatory obligations and rapidly collect, share, archive, and export audit ...
(Date:12/6/2016)... ... 06, 2016 , ... The OSHA Training Center at ... Center headquartered in Northern California, has announced the addition of a Public Sector ... training to public sector employees. , “The primary goal of the Public Sector ...
(Date:12/6/2016)... ... December 06, 2016 , ... U.S. Security Associates (USA) was ... for their industry leading training methods that engage their associates and link their ... global elite in employer-sponsored training and development programs. , “The 2017 Training Top ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... -- Several leading Alzheimer,s disease experts will participate in ... 11 a.m. EST on December 6 in advance of ... Alzheimer,s Disease (CTAD). The program will include discussions on ... targets that address deficient glucose metabolism observed in Alzheimer,s ... another therapy targeting the amyloid hypothesis, now more than ...
(Date:12/5/2016)... 5, 2016 Research and Markets has ... (Instruments, Consumables), Application (Biomedical & Biochemical Research, Disease Diagnostics), End User ... to 2021" report to their offering. ... , , ... in 2021 from USD 574.8 Million in 2016, growing at a ...
(Date:12/5/2016)... PUNE, India , December 5, 2016 According to ... Product Type and by Application - Global Opportunity Analysis and Industry Forecast, 2014 ... and is expected to reach $5,255 million by 2022, growing at a CAGR ... 2015 with more than four-fifths share. Continue Reading ... ...
Breaking Medicine Technology: