Navigation Links
Common gene variants explain 42 percent of antidepressant response
Date:3/28/2013

Philadelphia, PA, March 28, 2013 Antidepressants are commonly prescribed for the treatment of depression, but many individuals do not experience symptom relief from treatment. The National Institute of Mental Health's STAR*D study, the largest and longest study ever conducted to evaluate depression treatment, found that only approximately one-third of patients responded within their initial medication trial and approximately one-third of patients did not have an adequate clinical response after being treated with several different medications. Thus, identifying predictors of antidepressant response could help to guide the treatment of this disorder.

A new study published in Biological Psychiatry now shares progress in identifying genomic predictors of antidepressant response.

Many previous studies have searched for genetic markers that may predict antidepressant response, but have done so despite not knowing the contribution of genetic factors. Dr. Katherine Tansey of Institute of Psychiatry at King's College London and colleagues resolved to answer that question.

"Our study quantified, for the first time, how much is response to antidepressant medication influenced by an individual's genetic make-up," said Tansey.

To perform this work, the researchers estimated the magnitude of the influence of common genetic variants on antidepressant response using a sample of 2,799 antidepressant-treated subjects with major depressive disorder and genome-wide genotyping data.

They found that genetic variants explain 42% of individual differences, and therefore, significantly influence antidepressant response.

"While we know that there are no genetic markers with strong effect, this means that there are many genetic markers involved. While each specific genetic marker may have a small effect, they may add up to make a meaningful prediction," Tansey added.

"We have a very long way to go to identify gene
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Paranoia Common After Mugging, Study Says
2. Hospital remains most common place of death for cancer patients in England
3. Commonly used cholesterol calculation underestimates heart disease danger for many
4. Michigan hospitals national leaders in preventing common and costly urinary tract infections
5. How common is The John Next Door?
6. Complications More Common Than Thought for Type of Hip Surgery
7. Suicidal Thoughts More Common in Kids With Autism: Study
8. Nurses can play key role in reducing deaths from worlds most common diseases
9. Common erectile dysfunction drug not helpful for heart failure patients, study finds
10. Common MS drugs taken together do not reduce relapse risk
11. Study: HPV Genital Warts is Most Common Sexually Transmitted Infection in U.S. Military, polyDNA Recommends Gene-Eden-VIR Against the HPV Infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... York, NY (PRWEB) , ... July 31, 2015 , ... ... Rodgers Theatre . Those looking to catch a new and refreshing show on ... won numerous awards and achievements including an Obie Award, Outer Critics Circle Award, Drama ...
(Date:7/31/2015)... Los Angeles, CA (PRWEB) , ... July 31, 2015 , ... ... of surgeons and cosmetic experts gathered to see if they could reach a consensus ... procedures, including breast augmentation and facelifts. Overall, the group reached 90 percent consensus on ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... pharmaceutical negligence is now available online at ( http://www.lawline.com/cle/course/its-a-wonderful-life-if-you-receive-the-right-meds-a-discussion-of-pharmaceutical-negligence ). Mr. ... approval rating from the nationwide audience. The course focused on the ...
(Date:7/31/2015)... ... 2015 , ... As part of their company mission, Dallas pet sitting ... organizations is essential to the longevity of their business. It is for that ... Professional Pet Sitters (NAPPS) annual Presents 4 Pets supply drive. Presents 4 ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Transfinder, a ... 2015. , Total sales were up 16 percent year-over-year for the first six months ... Antonio Civitella said he expected Transfinder to beat last year’s record-revenue mark of $10.4 ...
Breaking Medicine News(10 mins):Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4Health News:Transfinder Closes First Half of 2015 with Record Revenue 2
... City Marathon 2007 and be Recognized for ... Runners and Avis, NEW YORK, Oct. 30 New ... today that Vincent Corso and Daniel Trush have,won the fourth-annual ... York City Marathon 2007. The award celebrates people who endeavor,to ...
... Conference Call and Webcast to Follow, ROCKVILLE, ... VNDA ), a biopharmaceutical company focused on the ... system disorders, today announced it will release results ... November 8, 2007, before the,market opens. A full ...
... a,statement of William V. Corr, executive director, Campaign ... has taken an important step,forward by recommending that ... health threats posed by secondhand smoke, while,preserving the ... as well. We,urge the Legislature to enact a ...
... Vote on Measure Thursday, WASHINGTON, Oct. 30 ... mouth are actually composed of 50% MERCURY, a,known neurotoxin? ... currently is not. Councilwoman Blondell Reynolds Brown wants to ... which ensures that patients are,given the opportunity to know ...
... preliminary, experts caution, , , TUESDAY, Oct. 30 (HealthDay News) ... a new study suggests that at least one virus ... treat some metastatic cancers. , Reporting in the ... Cancer Institute , researchers explained that the virus, Seneca ...
... post-traumatic stress disorder had a ,protective, effect , , TUESDAY, ... veterans suffering from depression finds that their risk factors ... other depressed Americans. , Specifically, the risk for suicide ... what,s seen in the general population. , And even ...
Cached Medicine News:Health News:Vincent Corso and Daniel Trush Win 2007 Avis 'We Try Harder' Awards 2Health News:Vincent Corso and Daniel Trush Win 2007 Avis 'We Try Harder' Awards 3Health News:Vanda Pharmaceuticals to Announce Third Quarter 2007 Financial Results on November 8, 2007 2Health News:Indiana Legislature Should Protect All Workers from Secondhand Smoke 2Health News:A Patients Right to Know: 'Silver Fillings' are 50% Mercury 2Health News:Virus Shows Some Cancer-Killing Abilities 2Health News:Virus Shows Some Cancer-Killing Abilities 3Health News:Younger Veterans at Greater Suicide Risk 2Health News:Younger Veterans at Greater Suicide Risk 3Health News:Younger Veterans at Greater Suicide Risk 4
(Date:7/30/2015)... VIEW, Calif. , July 30, 2015 ... it will release its second quarter 2015 financial results ... 2015.   In conjunction with the release, the Company ... at 5:00 p.m. Eastern Time on ... of the quarter and other business developments. ...
(Date:7/30/2015)... SAN DIEGO , July 30, 2015 /PRNewswire/ ... a medical device company and manufacturer of the ... it has entered into non-exclusive Development Agreements with ... generation Tandem insulin pumps with the Dexcom G5 ... "Integrating Tandem,s next generation pump platform with ...
(Date:7/30/2015)... WASHINGTON , July 30, 2015  Today we bring you a special edition ... wanted to remind you about some of our Medicare resources and continue highlighting the ... Check out our latest infographics and videos ... ... ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: