Navigation Links
Common gene variants explain 42 percent of antidepressant response
Date:3/28/2013

Philadelphia, PA, March 28, 2013 Antidepressants are commonly prescribed for the treatment of depression, but many individuals do not experience symptom relief from treatment. The National Institute of Mental Health's STAR*D study, the largest and longest study ever conducted to evaluate depression treatment, found that only approximately one-third of patients responded within their initial medication trial and approximately one-third of patients did not have an adequate clinical response after being treated with several different medications. Thus, identifying predictors of antidepressant response could help to guide the treatment of this disorder.

A new study published in Biological Psychiatry now shares progress in identifying genomic predictors of antidepressant response.

Many previous studies have searched for genetic markers that may predict antidepressant response, but have done so despite not knowing the contribution of genetic factors. Dr. Katherine Tansey of Institute of Psychiatry at King's College London and colleagues resolved to answer that question.

"Our study quantified, for the first time, how much is response to antidepressant medication influenced by an individual's genetic make-up," said Tansey.

To perform this work, the researchers estimated the magnitude of the influence of common genetic variants on antidepressant response using a sample of 2,799 antidepressant-treated subjects with major depressive disorder and genome-wide genotyping data.

They found that genetic variants explain 42% of individual differences, and therefore, significantly influence antidepressant response.

"While we know that there are no genetic markers with strong effect, this means that there are many genetic markers involved. While each specific genetic marker may have a small effect, they may add up to make a meaningful prediction," Tansey added.

"We have a very long way to go to identify gene
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Paranoia Common After Mugging, Study Says
2. Hospital remains most common place of death for cancer patients in England
3. Commonly used cholesterol calculation underestimates heart disease danger for many
4. Michigan hospitals national leaders in preventing common and costly urinary tract infections
5. How common is The John Next Door?
6. Complications More Common Than Thought for Type of Hip Surgery
7. Suicidal Thoughts More Common in Kids With Autism: Study
8. Nurses can play key role in reducing deaths from worlds most common diseases
9. Common erectile dysfunction drug not helpful for heart failure patients, study finds
10. Common MS drugs taken together do not reduce relapse risk
11. Study: HPV Genital Warts is Most Common Sexually Transmitted Infection in U.S. Military, polyDNA Recommends Gene-Eden-VIR Against the HPV Infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... IL (PRWEB) July 25, 2014 Today, nearly ... tumor, and yet, when it comes to pinpointing causes or ... now, we don’t know who, we don’t know when, and ... M. Wilson, MNA, president & CEO, American Brain Tumor Association. ... the American Brain Tumor Association funds research to pursue answers ...
(Date:7/25/2014)... According to the new report "Sapphire ... and Geography - Analysis & Forecast to 2013 - ... to reach $3.01 Billion by 2020 at a CAGR ... devices is expected to reach $6.17 billion by 2020 ... analysis of application and geography. , Browse more than ...
(Date:7/25/2014)... Providence, RI (PRWEB) July 25, 2014 ... Island Quality Improvement Organization (QIO) was recently awarded ... from the Centers for Medicare & Medicaid Services ... to fourteen organizations across the United States, represent ... In order to successfully execute the contract initiatives, ...
(Date:7/25/2014)... 2014 Garth Brooks Chicago tickets go ... Arena in Rosemont. Garth Brooks was one of the leaders ... first single in 1989. Since "Much Too Young (To Feel This ... from the Tulsa, Okl. native and in the years that he ... back on a stage and in the recording studio. Between 2001 ...
(Date:7/25/2014)... Dallas, Texas (PRWEB) July 25, 2014 The ... key factors leading to the growth of the US PBM ... the volume and value of pharmaceutical sales in the US ... sales can be attributed to rise in the prescription volume ... “The US Pharmacy Benefit Management (PBM): 2013 Edition” the demand ...
Breaking Medicine News(10 mins):Health News:Brain Tumor Causes and Risk Factors Elude Scientists 2Health News:Brain Tumor Causes and Risk Factors Elude Scientists 3Health News:Brain Tumor Causes and Risk Factors Elude Scientists 4Health News:Sapphire Technology Market Estimated to Reach $3.01 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Sapphire Technology Market Estimated to Reach $3.01 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Sapphire Technology Market Estimated to Reach $3.01 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Sapphire Technology Market Estimated to Reach $3.01 Billion by 2020 – New Report by MarketsandMarkets 5Health News:Sapphire Technology Market Estimated to Reach $3.01 Billion by 2020 – New Report by MarketsandMarkets 6Health News:Healthcentric Advisors and Qualidigm Partner to Improve the Healthcare Quality for New England 2Health News:Healthcentric Advisors and Qualidigm Partner to Improve the Healthcare Quality for New England 3Health News:Healthcentric Advisors and Qualidigm Partner to Improve the Healthcare Quality for New England 4Health News:Garth Brooks Chicago Tickets for Performance at Allstate Arena in Rosemont Go On Sale July 25th 2Health News:Garth Brooks Chicago Tickets for Performance at Allstate Arena in Rosemont Go On Sale July 25th 3Health News:US Pharmacy Benefit Management (PBM) Market Trends and Developments Now Available at MarketReportsOnline.com 2Health News:US Pharmacy Benefit Management (PBM) Market Trends and Developments Now Available at MarketReportsOnline.com 3
... and healthy food, beer drinkers are attracted more towards junk ... drinkers when compared to beer drinkers. Now researchers at the ... beer drinkers buy unhealthy food such as chips and ready ... News. ,Studying 3.5 million supermarket transactions, the ...
... cereals is facing the wrath of a consumer group which ... kids.,In fact they are contemplating suing the company and Viacom ... letters had been sent to Kellogg and Viacom saying it ... days rather than sue. ,Still, the Center added, ...
... can be increased by drinking coffee, according to scientists belonging ... Coffee in effect stimulates a part of the brain which ... seen in only those who do not consume the beverage ... rats involved had never been administered caffeine before. ...
... stress at the place of work, according to a recent ... connection between stress and poor health has also been identified ... the metabolic syndrome and stress among the 10,000 civil servants ... years who were studied, which also involves high blood pressure ...
... after a clash between Uttar Pradesh Government Railway Police ... Medical Entrance in Meerut by Meerut Nauchandi Express lead ... occurred due to the police personnel occupying the reserved ... on strike in seven state medical colleges for three ...
... of The Journal of Neuroscience, says that Alzheimer's disease (AD) ... division. This finding in laboratory// mice could help scientists understand ... ,"If you could stop cell cycling, you might be ... a fresh approach to therapy for Alzheimer's and other diseases, ...
Cached Medicine News:Health News:Dividing Nerve Cells Could Trigger Alzheimer's Disease 2
(Date:7/25/2014)... July 25, 2014 /PRNewswire-iReach/ -- ScriptPro, of ... Powers Lake, Wisconsin , announce ... distribution and co-marketing agreement allowing ScriptPro to bring ... the United States . ScriptPro ... and workflow systems to retail and ambulatory pharmacies. ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Full ... as the new Vice President of Business Development. ... 30 years in a number of different business development ... industry. These positions were primarily related to business development/sales ... the past 30 years makes him a key and ...
(Date:7/25/2014)... -- CVS Caremark Corporation (NYSE: CVS ) will ... 2014, at 8:30 a.m. (EDT) with analysts and investors ... An audio webcast of the conference call will ... the CVS Caremark website for all interested parties.  To ... will be archived and available on the web site ...
Breaking Medicine Technology:ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 2ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 3Contract Research Organization WCCT Global Welcomes Peter Nieto as Vice President of Business Development 2
... Eli Lilly and Company (NYSE: LLY ) has ... by Working Mother magazine. This is the 17th ... year, the Working Mother 100 Best Companies initiative ... percent of this year,s winning companies offer flex-time hours, telecommuting, ...
... Many failing NHS hospitals across the UK will be ... according to a leading figure. Tony Blair,s former health ... not have enough money and therefore will need radical action to ... tank, the professor argues that the NHS hospitals must either change ...
Cached Medicine Technology:Lilly Celebrates 17th Consecutive Year as One of Working Mother 100 Best Companies 2Failing NHS Hospitals in Need of a Business Rescue Plan 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: