Navigation Links
Common gene variants account for most of the genetic risk for autism
Date:7/20/2014

tors, it is important to know that there is underlying risk in the family genetic architecture itself."

Gauging the collective impact on autism risk of variations in the genetic code shared by most people, individually much subtler in effect, has proven to be even more challenging. Limitations in sample size and composition have made it difficult to detect these effects and to estimate the relative influence of such common, rare inherited and rare, spontaneous de novo variation. Differences in methods and statistical models have also resulted in estimates of autism heritability ranging from 17 to 50 percent.

Meanwhile, recent genome-wide studies of schizophrenia have achieved large enough sample sizes to reveal involvement of well over 100 common gene variants in that disorder. These promise improved understanding of the underlying biology and even development of risk-scores, which could help predict who might benefit from early interventions to nip psychotic episodes in the bud.

With their new study, autism genetics is beginning to catch up, say the researchers. The PAGES study was made possible by Sweden's universal health registry, which allowed investigators to compare very large samples (n~3000 in the current study) of people with autism with matched controls. Researchers also employed new statistical methods that allowed them to more reliably sort out the heritability of the disorder. In addition, they were able to compare their results with a parallel family-based study in the Swedish population, which took into account data from twins, cousins and factors such as age of the father at birth and parents' psychiatric history.

"This is a different kind of analysis than employed in previous studies," says Thomas Lehner, PhD, Chief of the National Institute of Mental Health's (NIMH) Genomics Research Branch. "Data from genome-wide association studies was used to identify a genetic model instead of focusing on just pin
'/>"/>

Contact: Elizabeth Dowling
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Household Problems Like Allergies, Odors, and Even Pet Dander Are Becoming More Common; Alen Corp. Unveils Its Solution to Poor Indoor Air With the New BreatheSmart FIT50
2. Protect Against the Most Common Form of Cancer in the U.S. During UV Safety Month
3. Burn Injuries More Common in Summer
4. Take Common Sense Steps to Stay Safe This Summer, from the July 2014 Harvard Men's Health Watch
5. Sleep disturbances, common in Parkinsons disease, can be early indicator of disease onset
6. Poll finds health most common major stressful event in Americans lives last year
7. The Lancet: New trial suggests cheaper drugs for common heart attack procedure could improve outcomes and save health budgets millions
8. Malnutrition screening of hospital patients common but hospitals failing on nutrition care
9. St. Johns wort can cause dangerous interactions with many common medications
10. Common herbal supplement can cause dangerous interactions
11. Genetics dominant risk factor in common cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... Italian public health researchers have released new data ... and other asbestos-related industries. Surviving Mesothelioma has just posted ... to read it now. , University researchers ... Medicine analyzed more than 15,000 cases of mesothelioma between ... asbestos cancer was most common. , “Asbestos cement ...
(Date:4/26/2015)... (PRWEB) April 26, 2015 From March ... and his wife, Trivedi Master™ Dahryn Trivedi, spent a ... approved research laboratories and institutions in the efforts of ... medicine and nutraceutical supplements for human health care. ... different research labs and institutions. All lab facilities are ...
(Date:4/26/2015)... Rosa, CA (PRWEB) April 26, 2015 In ... from Washington State University evaluated the head-neck biomechanics occurring during ... of the study were able to determine that use of ... much as 3 to 5 times - more than when ... surprising outcome for such a study, but pointing out the ...
(Date:4/25/2015)... April 26, 2015 The National ... , a national endeavor to prepare nurses to provide ... a great success, according to a new report by ... original funding partners. , The project began in ... (CCP), under the direction of Elaine Tagliareni, EdD, RN, ...
(Date:4/25/2015)... The Hon. Ellen Tauscher, Independent Chair of the ... following the deadly earthquake in Nepal: , "Today a ... deaths of more than 1,000 people. The aftershocks ... India and other parts of South Asia. I ... of Nepal and the families of the victims. ...
Breaking Medicine News(10 mins):Health News:New Investigation Finds Mesothelioma “Clusters” Around Italian Cement Plants, According to Surviving Mesothelioma 2Health News:Trivedi Science™ Has Started Scientific Research to Create More Effective Pharmaceuticals and Nutraceuticals 2Health News:Trivedi Science™ Has Started Scientific Research to Create More Effective Pharmaceuticals and Nutraceuticals 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 3
... Canadian television viewers will get,a chance to learn ... the,documentary "The Brain That Changes Itself" airs on the ... book of the same name by,author Norman Doidge, MD, ... and features the science, scientists, products and,customers of Posit ...
... Service Reductions , , WASHINGTON, Dec. ... Care (CQRC) -- an alliance of the country,s leading home oxygen ... oxygen beneficiaries -- are anxiously preparing for massive Medicare cuts to ... , , The Medicare Part ...
... feel better mentally, physically, researchers say , , WEDNESDAY, Dec. ... to work out their anger with exercise, a new ... otherwise healthy 7- to 11-year-olds found they reduced both ... a 10- to 15-week after-school aerobic exercise program. The ...
... Dec. 3 Many dentists and dental office,staff ... however, very,few dental professionals have taken advantage of ... while offering,the convenience of determining benefit information while ... "Paper submissions typically ...
... new release of HeartScore the interactive tool designed to ... and stroke in Europe created by the European Society ... 2008 at www.HeartScore.org . , This revised version ... patient data history and progress monitoring. Three formats are ...
... Dec. 3 New footage released today from an undercover ... staff deliberately violating the state,s mandatory reporting laws for sexual ... shows Lila Rose, a UCLA student journalist and ... 13-year-old girl. In an appointment with a Planned Parenthood nurse, ...
Cached Medicine News:Health News:Posit Science Featured in Canadian Documentary on the Brain 2Health News:Home Oxygen Community Braces for Massive Cuts to Medicare's Home Oxygen Benefit Starting January '09 2Health News:Home Oxygen Community Braces for Massive Cuts to Medicare's Home Oxygen Benefit Starting January '09 3Health News:Electronic Submission for Dental Predeterminations May Increase Efficiency, Patient Satisfaction 2Health News:The ESC launches a new release of HeartScore 2Health News:The ESC launches a new release of HeartScore 3Health News:Live Action: New Video Shows Indiana Planned Parenthood Covering Up Rape of 13-year old Girl 2
(Date:4/24/2015)...  Elekta has CE marked the latest version (v5.10) ... enabling European clinics to deliver a sophisticated radiation therapy ... 3D planning, IMRT, VMAT and stereotactic planning – all ... Monaco ® v5.10 provides significant planning ... in 3D planning as well as the addition of ...
(Date:4/23/2015)... April 23, 2015  ResMed Inc. (NYSE: RMD ... 31, 2015.  Revenue for the quarter was $422.5 million, ... March 31, 2014 (a 13 percent increase on a ... increase of 1 percent compared to the quarter ended ... quarter were $0.64, an increase of 2 percent compared ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
Breaking Medicine Technology:Elekta CE marks for Monaco v5.10 treatment planning system 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 11ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 12ResMed Inc. Announces Results for the Third Quarter of Fiscal Year 2015 13Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2
... 5, 2011 Express Scripts contributed more than $226 ... economic analysis of the company,s data by a university ... The economic impact study, presented today to state economic ... support 2,665 direct and indirect jobs in the state. ...
... NeuroVasx announced today that the FDA ... Humanitarian Use Device (HDE) for the treatment of large, ... most difficult to treat.  The HDE allows for the ... the U.S. (Logo: http://photos.prnewswire.com/prnh/20110405/CG77724LOGO ) ...
Cached Medicine Technology:Express Scripts Injects $226 Million Into Arizona Economy, Study Finds 2NeuroVasx Receives FDA Approval for cPAX Aneurysm Treatment System 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: